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Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and prednisone.

Abstract

BACKGROUND

Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin.

METHODS

A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia.

RESULTS

Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission.

CONCLUSION

This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Unit of Dermatology, Complexo Hospitalar Padre Bento, Guarulhos, Brazil. prcriado@directnet.com.br

    , , , , ,

    Source

    MeSH

    Adult
    Anti-Inflammatory Agents
    Diagnosis, Differential
    Drug Therapy, Combination
    Female
    Histiocytosis
    Humans
    Melphalan
    Necrobiosis Lipoidica
    Paraproteinemias
    Prednisone

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    12060508

    Citation

    Criado, P R., et al. "Necrobiotic Xanthogranuloma With Lambda Paraproteinemia: Case Report of Successful Treatment With Melphalan and Prednisone." The Journal of Dermatological Treatment, vol. 13, no. 2, 2002, pp. 87-9.
    Criado PR, Vasconcellos C, Pegas JR, et al. Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and prednisone. J Dermatolog Treat. 2002;13(2):87-9.
    Criado, P. R., Vasconcellos, C., Pegas, J. R., Lopes, L. F., Ramos, C. F., Tebcherani, A. J., & Valente, N. Y. (2002). Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and prednisone. The Journal of Dermatological Treatment, 13(2), pp. 87-9.
    Criado PR, et al. Necrobiotic Xanthogranuloma With Lambda Paraproteinemia: Case Report of Successful Treatment With Melphalan and Prednisone. J Dermatolog Treat. 2002;13(2):87-9. PubMed PMID: 12060508.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and prednisone. AU - Criado,P R, AU - Vasconcellos,C, AU - Pegas,J R, AU - Lopes,L F, AU - Ramos,C F, AU - Tebcherani,A J, AU - Valente,N Y S, PY - 2002/6/13/pubmed PY - 2002/8/7/medline PY - 2002/6/13/entrez SP - 87 EP - 9 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 13 IS - 2 N2 - BACKGROUND: Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin. METHODS: A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia. RESULTS: Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission. CONCLUSION: This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/12060508/Necrobiotic_xanthogranuloma_with_lambda_paraproteinemia:_case_report_of_successful_treatment_with_melphalan_and_prednisone_ L2 - http://www.tandfonline.com/doi/full/10.1080/095466302317584458 DB - PRIME DP - Unbound Medicine ER -