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Formulation approaches for orally administered poorly soluble drugs.
Pharmazie. 2002 May; 57(5):291-300.P

Abstract

Despite having pharmacodynamic or target activity, many drugs fail in the drug development process due to poor bioavailability, and presently marketed conventional dosage forms of poorly soluble drugs employ high doses leading to potential toxicity. The introduction of the Biopharmaceutic Classification System (BCS) has provided a basis to categorize drugs based on the two major parameters affecting absorption, solubility and permeability. Several techniques can be employed to enhance the absorption and bioavailability of poorly soluble and poorly permeable drugs based on the BCS concept. This article is an attempt to summarize the development of various formulation approaches that are currently employed to enhance bioavailability of orally administered poorly soluble drugs.

Authors+Show Affiliations

Pinnamaneni S
Department of Pharmaceutical Sciences, Idaho State University, Pocatello, Idaho, USA.
Das NG
No affiliation info available
Das SK
No affiliation info available

MeSH

BiopharmaceuticsChemical PhenomenaChemistry, PharmaceuticalChemistry, PhysicalExcipientsPermeabilitySolubility

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12061250

Citation

Pinnamaneni, S, et al. "Formulation Approaches for Orally Administered Poorly Soluble Drugs." Die Pharmazie, vol. 57, no. 5, 2002, pp. 291-300.
Pinnamaneni S, Das NG, Das SK. Formulation approaches for orally administered poorly soluble drugs. Pharmazie. 2002;57(5):291-300.
Pinnamaneni, S., Das, N. G., & Das, S. K. (2002). Formulation approaches for orally administered poorly soluble drugs. Die Pharmazie, 57(5), 291-300.
Pinnamaneni S, Das NG, Das SK. Formulation Approaches for Orally Administered Poorly Soluble Drugs. Pharmazie. 2002;57(5):291-300. PubMed PMID: 12061250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation approaches for orally administered poorly soluble drugs. AU - Pinnamaneni,S, AU - Das,N G, AU - Das,S K, PY - 2002/6/14/pubmed PY - 2002/7/16/medline PY - 2002/6/14/entrez SP - 291 EP - 300 JF - Die Pharmazie JO - Pharmazie VL - 57 IS - 5 N2 - Despite having pharmacodynamic or target activity, many drugs fail in the drug development process due to poor bioavailability, and presently marketed conventional dosage forms of poorly soluble drugs employ high doses leading to potential toxicity. The introduction of the Biopharmaceutic Classification System (BCS) has provided a basis to categorize drugs based on the two major parameters affecting absorption, solubility and permeability. Several techniques can be employed to enhance the absorption and bioavailability of poorly soluble and poorly permeable drugs based on the BCS concept. This article is an attempt to summarize the development of various formulation approaches that are currently employed to enhance bioavailability of orally administered poorly soluble drugs. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/12061250/Formulation_approaches_for_orally_administered_poorly_soluble_drugs_ DB - PRIME DP - Unbound Medicine ER -