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Development and validation of a HPLC method for the determination of cetirizine in pharmaceutical dosage forms.
Pharmazie. 2002 May; 57(5):313-5.P

Abstract

A rapid, simple and accurate HPLC method is described for the assay of cetirizine in commercial dosage forms. Methanol was found to be a suitable extraction solvent for tablets and for preparing solutions from drops and oral liquids. The samples were chromatographed on a Nova-Pak C18 column and UV detected at 227 nm. The elution was achieved isocratically with a mobile phase of 0.067 M phosphate buffer pH 3.40/acetonitrile (1:1, v/v). Ketotifen was applied as an internal standard. The method was validated for linearity, precision, accuracy and limit of detection. The recovery (mean +/- SD) for tablets was 100.88% +/- 0.8967, for drops 100.35% +/- 0.4062 and for solutions 101.20% +/- 1.1698.

Authors+Show Affiliations

Paw B
Medical University of Lublin, Faculty of Pharmacy, Department of Medicinal Chemistry, Lublin, Poland.
Misztal G
No affiliation info available
Hopkała H
No affiliation info available
Drozd J
No affiliation info available

MeSH

Anti-Allergic AgentsCalibrationCetirizineChromatography, High Pressure LiquidHydrogen-Ion ConcentrationIndicators and ReagentsReproducibility of ResultsSpectrophotometry, UltravioletTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12061254

Citation

Paw, B, et al. "Development and Validation of a HPLC Method for the Determination of Cetirizine in Pharmaceutical Dosage Forms." Die Pharmazie, vol. 57, no. 5, 2002, pp. 313-5.
Paw B, Misztal G, Hopkała H, et al. Development and validation of a HPLC method for the determination of cetirizine in pharmaceutical dosage forms. Pharmazie. 2002;57(5):313-5.
Paw, B., Misztal, G., Hopkała, H., & Drozd, J. (2002). Development and validation of a HPLC method for the determination of cetirizine in pharmaceutical dosage forms. Die Pharmazie, 57(5), 313-5.
Paw B, et al. Development and Validation of a HPLC Method for the Determination of Cetirizine in Pharmaceutical Dosage Forms. Pharmazie. 2002;57(5):313-5. PubMed PMID: 12061254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and validation of a HPLC method for the determination of cetirizine in pharmaceutical dosage forms. AU - Paw,B, AU - Misztal,G, AU - Hopkała,H, AU - Drozd,J, PY - 2002/6/14/pubmed PY - 2002/7/16/medline PY - 2002/6/14/entrez SP - 313 EP - 5 JF - Die Pharmazie JO - Pharmazie VL - 57 IS - 5 N2 - A rapid, simple and accurate HPLC method is described for the assay of cetirizine in commercial dosage forms. Methanol was found to be a suitable extraction solvent for tablets and for preparing solutions from drops and oral liquids. The samples were chromatographed on a Nova-Pak C18 column and UV detected at 227 nm. The elution was achieved isocratically with a mobile phase of 0.067 M phosphate buffer pH 3.40/acetonitrile (1:1, v/v). Ketotifen was applied as an internal standard. The method was validated for linearity, precision, accuracy and limit of detection. The recovery (mean +/- SD) for tablets was 100.88% +/- 0.8967, for drops 100.35% +/- 0.4062 and for solutions 101.20% +/- 1.1698. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/12061254/Development_and_validation_of_a_HPLC_method_for_the_determination_of_cetirizine_in_pharmaceutical_dosage_forms_ DB - PRIME DP - Unbound Medicine ER -