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Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone.
Z Naturforsch C 2002 Mar-Apr; 57(3-4):372-8ZN

Abstract

The Copey tree (Clusia rosea) has a large distribution in Cuba and its floral resin is a rich source of polyisoprenylated benzophenones. To determine the presence of these natural products, we carried out a study by HPLC of 21 propolis samples produced by honey bees (Apis mellifera) from different provinces of Cuba. Nemorosone resulted to be the most abundant polyisoprenylated benzophenone and the mixture of xanthochymol and guttiferone E was also observed, but in minor proportion. We studied the biological activity of the pure natural product nemorosone and its methyl derivatives. We found that nemorosone has cytotoxic activity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251). It also exhibited antioxidant capacity. Methylated nemorosone exhibited less biological activity than the natural product.

Authors+Show Affiliations

Instituto de Farmacia y Alimentos, Universidad de la Habana, Cuba.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12064743

Citation

Cuesta-Rubio, Osmany, et al. "Polyisoprenylated Benzophenones in Cuban Propolis; Biological Activity of Nemorosone." Zeitschrift Fur Naturforschung. C, Journal of Biosciences, vol. 57, no. 3-4, 2002, pp. 372-8.
Cuesta-Rubio O, Frontana-Uribe BA, Ramírez-Apan T, et al. Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. Z Naturforsch, C, J Biosci. 2002;57(3-4):372-8.
Cuesta-Rubio, O., Frontana-Uribe, B. A., Ramírez-Apan, T., & Cárdenas, J. (2002). Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 57(3-4), pp. 372-8.
Cuesta-Rubio O, et al. Polyisoprenylated Benzophenones in Cuban Propolis; Biological Activity of Nemorosone. Z Naturforsch, C, J Biosci. 2002;57(3-4):372-8. PubMed PMID: 12064743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. AU - Cuesta-Rubio,Osmany, AU - Frontana-Uribe,Bernardo A, AU - Ramírez-Apan,Teresa, AU - Cárdenas,Jorge, PY - 2002/6/18/pubmed PY - 2002/7/19/medline PY - 2002/6/18/entrez SP - 372 EP - 8 JF - Zeitschrift fur Naturforschung. C, Journal of biosciences JO - Z. Naturforsch., C, J. Biosci. VL - 57 IS - 3-4 N2 - The Copey tree (Clusia rosea) has a large distribution in Cuba and its floral resin is a rich source of polyisoprenylated benzophenones. To determine the presence of these natural products, we carried out a study by HPLC of 21 propolis samples produced by honey bees (Apis mellifera) from different provinces of Cuba. Nemorosone resulted to be the most abundant polyisoprenylated benzophenone and the mixture of xanthochymol and guttiferone E was also observed, but in minor proportion. We studied the biological activity of the pure natural product nemorosone and its methyl derivatives. We found that nemorosone has cytotoxic activity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251). It also exhibited antioxidant capacity. Methylated nemorosone exhibited less biological activity than the natural product. SN - 0939-5075 UR - https://www.unboundmedicine.com/medline/citation/12064743/Polyisoprenylated_benzophenones_in_cuban_propolis L2 - https://www.degruyter.com/doi/10.1515/znc-2002-3-429 DB - PRIME DP - Unbound Medicine ER -