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Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone.

Abstract

The Copey tree (Clusia rosea) has a large distribution in Cuba and its floral resin is a rich source of polyisoprenylated benzophenones. To determine the presence of these natural products, we carried out a study by HPLC of 21 propolis samples produced by honey bees (Apis mellifera) from different provinces of Cuba. Nemorosone resulted to be the most abundant polyisoprenylated benzophenone and the mixture of xanthochymol and guttiferone E was also observed, but in minor proportion. We studied the biological activity of the pure natural product nemorosone and its methyl derivatives. We found that nemorosone has cytotoxic activity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251). It also exhibited antioxidant capacity. Methylated nemorosone exhibited less biological activity than the natural product.

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  • Authors+Show Affiliations

    ,

    Instituto de Farmacia y Alimentos, Universidad de la Habana, Cuba.

    , ,

    Source

    MeSH

    Animals
    Bees
    Benzophenones
    Carcinoma, Squamous Cell
    Cell Survival
    Central Nervous System Neoplasms
    Chromatography, High Pressure Liquid
    Cuba
    HeLa Cells
    Humans
    Male
    Molecular Conformation
    Propolis
    Prostatic Neoplasms
    Protein Prenylation
    Tumor Cells, Cultured

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12064743

    Citation

    Cuesta-Rubio, Osmany, et al. "Polyisoprenylated Benzophenones in Cuban Propolis; Biological Activity of Nemorosone." Zeitschrift Fur Naturforschung. C, Journal of Biosciences, vol. 57, no. 3-4, 2002, pp. 372-8.
    Cuesta-Rubio O, Frontana-Uribe BA, Ramírez-Apan T, et al. Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. Z Naturforsch, C, J Biosci. 2002;57(3-4):372-8.
    Cuesta-Rubio, O., Frontana-Uribe, B. A., Ramírez-Apan, T., & Cárdenas, J. (2002). Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 57(3-4), pp. 372-8.
    Cuesta-Rubio O, et al. Polyisoprenylated Benzophenones in Cuban Propolis; Biological Activity of Nemorosone. Z Naturforsch, C, J Biosci. 2002;57(3-4):372-8. PubMed PMID: 12064743.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Polyisoprenylated benzophenones in cuban propolis; biological activity of nemorosone. AU - Cuesta-Rubio,Osmany, AU - Frontana-Uribe,Bernardo A, AU - Ramírez-Apan,Teresa, AU - Cárdenas,Jorge, PY - 2002/6/18/pubmed PY - 2002/7/19/medline PY - 2002/6/18/entrez SP - 372 EP - 8 JF - Zeitschrift fur Naturforschung. C, Journal of biosciences JO - Z. Naturforsch., C, J. Biosci. VL - 57 IS - 3-4 N2 - The Copey tree (Clusia rosea) has a large distribution in Cuba and its floral resin is a rich source of polyisoprenylated benzophenones. To determine the presence of these natural products, we carried out a study by HPLC of 21 propolis samples produced by honey bees (Apis mellifera) from different provinces of Cuba. Nemorosone resulted to be the most abundant polyisoprenylated benzophenone and the mixture of xanthochymol and guttiferone E was also observed, but in minor proportion. We studied the biological activity of the pure natural product nemorosone and its methyl derivatives. We found that nemorosone has cytotoxic activity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251). It also exhibited antioxidant capacity. Methylated nemorosone exhibited less biological activity than the natural product. SN - 0939-5075 UR - https://www.unboundmedicine.com/medline/citation/12064743/Polyisoprenylated_benzophenones_in_cuban_propolis L2 - https://www.lens.org/lens/search?q=citation_id:12064743 DB - PRIME DP - Unbound Medicine ER -