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Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia.
APMIS. 2002 Feb; 110(2):132-9.A

Abstract

Patients with hypergastrinemia secondary to achlorhydria have an increased risk of developing ECL cell carcinoids and gastric adenocarcinomas. Hypergastrinemia is central in the pathogenesis of ECL cell carcinoids, but the link between gastrin and gastric carcinomas is controversial. During neoplastic transformation ECL cells may, however, lose many of their neuroendocrine characteristics, making them difficult to recognise as neuroendocrine with conventional immunohistochemical techniques. Neuroendocrine differentiation was therefore examined in eight gastric adenocarcinomas found in seven patients with severe hypergastrinemia and/or pernicious anemia using a monoclonal antibody towards chromogranin A and immunohistochemistry without and with a sensitive signal amplification technique. The Sevier-Munger method was used as a more specific marker of ECL cells. Seven of the carcinomas contained scattered neuroendocrine tumour cells. When using signal amplification, an increase in the number of immunoreactive neoplastic cells was seen. In many tumours, clusters or confluent sheets of such cells were disclosed, suggesting a neuroendocrine and ECL cell origin. These tumours may therefore be ECL cell carcinomas and hypergastrinemia may thus be involved in the tumourigenesis.

Authors+Show Affiliations

Norwegian University of Science and Technology, Faculty of Medicine, Department of Intra-abdominal Diseases, Trondheim.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12064868

Citation

Qvigstad, Gunnar, et al. "Neuroendocrine Differentiation in Gastric Adenocarcinomas Associated With Severe Hypergastrinemia And/or Pernicious Anemia." APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, vol. 110, no. 2, 2002, pp. 132-9.
Qvigstad G, Qvigstad T, Westre B, et al. Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia. APMIS. 2002;110(2):132-9.
Qvigstad, G., Qvigstad, T., Westre, B., Sandvik, A. K., Brenna, E., & Waldum, H. L. (2002). Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 110(2), 132-9.
Qvigstad G, et al. Neuroendocrine Differentiation in Gastric Adenocarcinomas Associated With Severe Hypergastrinemia And/or Pernicious Anemia. APMIS. 2002;110(2):132-9. PubMed PMID: 12064868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia. AU - Qvigstad,Gunnar, AU - Qvigstad,Tor, AU - Westre,Bjørn, AU - Sandvik,Arne K, AU - Brenna,Eiliv, AU - Waldum,Helge L, PY - 2002/6/18/pubmed PY - 2002/7/6/medline PY - 2002/6/18/entrez SP - 132 EP - 9 JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica JO - APMIS VL - 110 IS - 2 N2 - Patients with hypergastrinemia secondary to achlorhydria have an increased risk of developing ECL cell carcinoids and gastric adenocarcinomas. Hypergastrinemia is central in the pathogenesis of ECL cell carcinoids, but the link between gastrin and gastric carcinomas is controversial. During neoplastic transformation ECL cells may, however, lose many of their neuroendocrine characteristics, making them difficult to recognise as neuroendocrine with conventional immunohistochemical techniques. Neuroendocrine differentiation was therefore examined in eight gastric adenocarcinomas found in seven patients with severe hypergastrinemia and/or pernicious anemia using a monoclonal antibody towards chromogranin A and immunohistochemistry without and with a sensitive signal amplification technique. The Sevier-Munger method was used as a more specific marker of ECL cells. Seven of the carcinomas contained scattered neuroendocrine tumour cells. When using signal amplification, an increase in the number of immunoreactive neoplastic cells was seen. In many tumours, clusters or confluent sheets of such cells were disclosed, suggesting a neuroendocrine and ECL cell origin. These tumours may therefore be ECL cell carcinomas and hypergastrinemia may thus be involved in the tumourigenesis. SN - 0903-4641 UR - https://www.unboundmedicine.com/medline/citation/12064868/Neuroendocrine_differentiation_in_gastric_adenocarcinomas_associated_with_severe_hypergastrinemia_and/or_pernicious_anemia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0903-4641&date=2002&volume=110&spage=132 DB - PRIME DP - Unbound Medicine ER -