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Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats.
Eur J Pharmacol 2002; 442(3):237-9EJ

Abstract

Feeding induced in rats by cerebroventricular (i.c.v.) injection of orphanin FQ was potently and dose-dependently reversed by peripheral injection of either the opioid antagonist naloxone or the cannabinoid CB(1) receptor antagonist SR 141716[N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophelyl)-4-methyl-3-pyrazole-carboxamine]. The combination of these two agents inhibited food intake in a manner suggestive of additivity or supra-additivity.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Pietras TA
    Department of Psychology, University of Florida, P.O. Box 112250, Gainesville, FL 32611-2250, USA.
    Rowland NE
    No affiliation info available

    MeSH

    AnimalsDose-Response Relationship, DrugDrug SynergismEatingFemaleHyperphagiaMaleNaloxoneNarcotic AntagonistsOpioid PeptidesPiperidinesPyrazolesRatsRats, Sprague-DawleyReceptors, CannabinoidReceptors, DrugRimonabant

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12065077

    Citation

    Pietras, Thomas A., and Neil E. Rowland. "Effect of Opioid and Cannabinoid Receptor Antagonism On Orphanin FQ-induced Hyperphagia in Rats." European Journal of Pharmacology, vol. 442, no. 3, 2002, pp. 237-9.
    Pietras TA, Rowland NE. Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats. Eur J Pharmacol. 2002;442(3):237-9.
    Pietras, T. A., & Rowland, N. E. (2002). Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats. European Journal of Pharmacology, 442(3), pp. 237-9.
    Pietras TA, Rowland NE. Effect of Opioid and Cannabinoid Receptor Antagonism On Orphanin FQ-induced Hyperphagia in Rats. Eur J Pharmacol. 2002 May 10;442(3):237-9. PubMed PMID: 12065077.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats. AU - Pietras,Thomas A, AU - Rowland,Neil E, PY - 2002/6/18/pubmed PY - 2002/9/18/medline PY - 2002/6/18/entrez SP - 237 EP - 9 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 442 IS - 3 N2 - Feeding induced in rats by cerebroventricular (i.c.v.) injection of orphanin FQ was potently and dose-dependently reversed by peripheral injection of either the opioid antagonist naloxone or the cannabinoid CB(1) receptor antagonist SR 141716[N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophelyl)-4-methyl-3-pyrazole-carboxamine]. The combination of these two agents inhibited food intake in a manner suggestive of additivity or supra-additivity. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/12065077/Effect_of_opioid_and_cannabinoid_receptor_antagonism_on_orphanin_FQ_induced_hyperphagia_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299902015510 DB - PRIME DP - Unbound Medicine ER -