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Defective erythropoiesis in bone marrow is a mechanism of anemia in children with cancer.
J Korean Med Sci. 2002 Jun; 17(3):337-40.JK

Abstract

Evaluation of the mechanism of anemia in cancer patients might help to select patients for the more efficient use of erythropoietin (EPO, a growth factor for erythroid precursor cells). For this, we investigated whether the production of EPO responds to anemia and the bone marrow responds to EPO appropriately, and whether chronic inflammation is inhibitory to erythropoiesis in anemic cancer children. Serum levels of EPO, soluble transferrin receptor (sTfR), tumor necrosis factor (TNF)-alpha, and erythrocyte sedimentation rate (ESR) in anemic cancer children were measured by enzyme-linked immunosorbent assay and then the correlation coefficients between those parameters and hemoglobin (Hb) were determined. Both in leukemia and in solid tumor patients, there were significant inverse correlations between Hb and EPO (leukemia: tau=-0.547, p<0.0001; solid tumor: tau=-0.591, p<0.0001), and between sTfR and EPO (leukemia: tau=-0.223, p<0.05; solid tumor: tau=-0.401, p<0.05). In contrast, sTfR showed a correlation with Hb in leukemia (tau=0.216, p<0.05) but not in solid tumor patients. sTfR was suppressed in 53% of anemic episodes of leukemia and 78% of those of solid tumor patients. Our results suggest that in cancer children, the EPO production is not defective and chronic inflammation is not inhibitory to erythropoiesis. Rather, the defective erythropoiesis itself is thought to be responsible for the anemia.

Authors+Show Affiliations

Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12068136

Citation

Kim, MunHee, et al. "Defective Erythropoiesis in Bone Marrow Is a Mechanism of Anemia in Children With Cancer." Journal of Korean Medical Science, vol. 17, no. 3, 2002, pp. 337-40.
Kim M, Lee J, Wu C, et al. Defective erythropoiesis in bone marrow is a mechanism of anemia in children with cancer. J Korean Med Sci. 2002;17(3):337-40.
Kim, M., Lee, J., Wu, C., Cho, S., & Lee, K. (2002). Defective erythropoiesis in bone marrow is a mechanism of anemia in children with cancer. Journal of Korean Medical Science, 17(3), 337-40.
Kim M, et al. Defective Erythropoiesis in Bone Marrow Is a Mechanism of Anemia in Children With Cancer. J Korean Med Sci. 2002;17(3):337-40. PubMed PMID: 12068136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Defective erythropoiesis in bone marrow is a mechanism of anemia in children with cancer. AU - Kim,MunHee, AU - Lee,JungHwa, AU - Wu,ChanWuk, AU - Cho,SungWon, AU - Lee,KwangChul, PY - 2002/6/18/pubmed PY - 2003/1/11/medline PY - 2002/6/18/entrez SP - 337 EP - 40 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 17 IS - 3 N2 - Evaluation of the mechanism of anemia in cancer patients might help to select patients for the more efficient use of erythropoietin (EPO, a growth factor for erythroid precursor cells). For this, we investigated whether the production of EPO responds to anemia and the bone marrow responds to EPO appropriately, and whether chronic inflammation is inhibitory to erythropoiesis in anemic cancer children. Serum levels of EPO, soluble transferrin receptor (sTfR), tumor necrosis factor (TNF)-alpha, and erythrocyte sedimentation rate (ESR) in anemic cancer children were measured by enzyme-linked immunosorbent assay and then the correlation coefficients between those parameters and hemoglobin (Hb) were determined. Both in leukemia and in solid tumor patients, there were significant inverse correlations between Hb and EPO (leukemia: tau=-0.547, p<0.0001; solid tumor: tau=-0.591, p<0.0001), and between sTfR and EPO (leukemia: tau=-0.223, p<0.05; solid tumor: tau=-0.401, p<0.05). In contrast, sTfR showed a correlation with Hb in leukemia (tau=0.216, p<0.05) but not in solid tumor patients. sTfR was suppressed in 53% of anemic episodes of leukemia and 78% of those of solid tumor patients. Our results suggest that in cancer children, the EPO production is not defective and chronic inflammation is not inhibitory to erythropoiesis. Rather, the defective erythropoiesis itself is thought to be responsible for the anemia. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/12068136/Defective_erythropoiesis_in_bone_marrow_is_a_mechanism_of_anemia_in_children_with_cancer_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2002.17.3.337 DB - PRIME DP - Unbound Medicine ER -