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Biphasic alcohol response differs in heavy versus light drinkers.
Alcohol Clin Exp Res. 2002 Jun; 26(6):827-35.AC

Abstract

BACKGROUND

Most studies of risk factors for alcohol-related problems have focused on biological family history as a primary risk factor. However, other factors, such as early-age heavy drinking, are also risk factors for sustained or progressive heavy consumption. Little is currently known about the mechanisms underlying binge or heavy drinking.

METHODS

This study examined the acute subjective and objective effects of ethanol in heavy drinkers versus light drinkers. Thirty-four subjects participated in this within-subjects study consisting of three early-evening testing sessions in which subjects consumed a beverage containing either 0.8 or 0.4 g/kg ethanol or placebo.

RESULTS

Compared with lighter drinkers, heavy drinkers were more sensitive to the positive stimulant-like effects of ethanol (p < 0.05), especially during the increasing limb of the blood alcohol curve. Heavy drinkers also showed less sedation and cortisol response after alcohol than the light drinkers (p < 0.05).

CONCLUSIONS

The results indicate that young adult binge drinkers show a biphasic alcohol response, with heightened sensitivity to stimulant-like alcohol effects and greater tolerance to sedative alcohol effects compared with their light-drinking counterparts.

Links

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    Authors+Show Affiliations

    King AC
    University of Chicago, Pritzker School of Medicine, Department of Psychiatry, Illinois 60637, USA. aking@yoda.bsd.uchicago.edu
    Houle T
    No affiliation info available
    de Wit H
    No affiliation info available
    Holdstock L
    No affiliation info available
    Schuster A
    No affiliation info available

    MeSH

    AdultAffectAlcohol DrinkingAnalysis of VarianceEthanolFemaleHumansHydrocortisoneMale

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12068251

    Clinical Trial Links

    Chicago Social Drinking Project

    Citation

    King, Andrea C., et al. "Biphasic Alcohol Response Differs in Heavy Versus Light Drinkers." Alcoholism, Clinical and Experimental Research, vol. 26, no. 6, 2002, pp. 827-35.
    King AC, Houle T, de Wit H, et al. Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res. 2002;26(6):827-35.
    King, A. C., Houle, T., de Wit, H., Holdstock, L., & Schuster, A. (2002). Biphasic alcohol response differs in heavy versus light drinkers. Alcoholism, Clinical and Experimental Research, 26(6), 827-35.
    King AC, et al. Biphasic Alcohol Response Differs in Heavy Versus Light Drinkers. Alcohol Clin Exp Res. 2002;26(6):827-35. PubMed PMID: 12068251.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Biphasic alcohol response differs in heavy versus light drinkers. AU - King,Andrea C, AU - Houle,Tim, AU - de Wit,Harriet, AU - Holdstock,Louis, AU - Schuster,Alyson, PY - 2002/6/18/pubmed PY - 2002/11/26/medline PY - 2002/6/18/entrez SP - 827 EP - 35 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 26 IS - 6 N2 - BACKGROUND: Most studies of risk factors for alcohol-related problems have focused on biological family history as a primary risk factor. However, other factors, such as early-age heavy drinking, are also risk factors for sustained or progressive heavy consumption. Little is currently known about the mechanisms underlying binge or heavy drinking. METHODS: This study examined the acute subjective and objective effects of ethanol in heavy drinkers versus light drinkers. Thirty-four subjects participated in this within-subjects study consisting of three early-evening testing sessions in which subjects consumed a beverage containing either 0.8 or 0.4 g/kg ethanol or placebo. RESULTS: Compared with lighter drinkers, heavy drinkers were more sensitive to the positive stimulant-like effects of ethanol (p < 0.05), especially during the increasing limb of the blood alcohol curve. Heavy drinkers also showed less sedation and cortisol response after alcohol than the light drinkers (p < 0.05). CONCLUSIONS: The results indicate that young adult binge drinkers show a biphasic alcohol response, with heightened sensitivity to stimulant-like alcohol effects and greater tolerance to sedative alcohol effects compared with their light-drinking counterparts. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/12068251/Biphasic_alcohol_response_differs_in_heavy_versus_light_drinkers_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0145-6008&amp;date=2002&amp;volume=26&amp;issue=6&amp;spage=827 DB - PRIME DP - Unbound Medicine ER -