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Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses.
Proc Nutr Soc 2001; 60(4):449-56PN

Abstract

Immunological unresponsiveness or hyporesponsiveness (tolerance) can be induced by feeding protein antigens to naive animals. Using a classical oral ovalbumin gut-induced tolerance protocol in BALB/c mice we investigated the effects of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on high-and low-dose oral tolerance (and in non-tolerised animals, i.e. effects of antigen challenge alone) in relation to lymphoproliferative, cytokine and antibody responses. Fish oil rich in long-chain n-3 fatty acids decreased both T-helper (Th) 1- and Th2-like responses. In contrast, borage (Borago officinalis) oil rich in n-6 PUFA, of which gamma-linolenic acid is rapidly metabolised to longer-chain n-6 PUFA, increased Thl-like responses and decreased Th2-like responses, and possibly enhanced suppressor cell or Th3-like activity. These findings are in general agreement with other studies on the effects of long chain n-3 PUFA on immune system functions, and characterise important differences between long-chain n-3 and n-6 PUFA, defining more precisely and broadly the immunological regulatory mechanisms involved. They are also discussed in relation to autoimmune disease.

Authors+Show Affiliations

School of Chemical and Life Sciences, University of Greenwich, London, UK. L.Harbige@gre.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12069397

Citation

Harbige, L S., and B A. Fisher. "Dietary Fatty Acid Modulation of Mucosally-induced Tolerogenic Immune Responses." The Proceedings of the Nutrition Society, vol. 60, no. 4, 2001, pp. 449-56.
Harbige LS, Fisher BA. Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses. Proc Nutr Soc. 2001;60(4):449-56.
Harbige, L. S., & Fisher, B. A. (2001). Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses. The Proceedings of the Nutrition Society, 60(4), pp. 449-56.
Harbige LS, Fisher BA. Dietary Fatty Acid Modulation of Mucosally-induced Tolerogenic Immune Responses. Proc Nutr Soc. 2001;60(4):449-56. PubMed PMID: 12069397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses. AU - Harbige,L S, AU - Fisher,B A, PY - 2002/6/19/pubmed PY - 2002/9/18/medline PY - 2002/6/19/entrez SP - 449 EP - 56 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 60 IS - 4 N2 - Immunological unresponsiveness or hyporesponsiveness (tolerance) can be induced by feeding protein antigens to naive animals. Using a classical oral ovalbumin gut-induced tolerance protocol in BALB/c mice we investigated the effects of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on high-and low-dose oral tolerance (and in non-tolerised animals, i.e. effects of antigen challenge alone) in relation to lymphoproliferative, cytokine and antibody responses. Fish oil rich in long-chain n-3 fatty acids decreased both T-helper (Th) 1- and Th2-like responses. In contrast, borage (Borago officinalis) oil rich in n-6 PUFA, of which gamma-linolenic acid is rapidly metabolised to longer-chain n-6 PUFA, increased Thl-like responses and decreased Th2-like responses, and possibly enhanced suppressor cell or Th3-like activity. These findings are in general agreement with other studies on the effects of long chain n-3 PUFA on immune system functions, and characterise important differences between long-chain n-3 and n-6 PUFA, defining more precisely and broadly the immunological regulatory mechanisms involved. They are also discussed in relation to autoimmune disease. SN - 0029-6651 UR - https://www.unboundmedicine.com/medline/citation/12069397/Dietary_fatty_acid_modulation_of_mucosally_induced_tolerogenic_immune_responses_ L2 - https://www.cambridge.org/core/product/identifier/S0029665101000520/type/journal_article DB - PRIME DP - Unbound Medicine ER -