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Prevention and treatment of chemo- and radiotherapy-induced oral mucositis.
Minerva Stomatol 2002; 51(5):173-86MS

Abstract

The administration of many chemo-radiotherapy regimens in patients with cancer may be complicated by toxicities that limit the clinicians' abilities to deliver the most effective doses of active agents. Oral mucositis is a major dose-limiting toxic effect and the most important cause of morbidity in patients undergoing chemo-radiotherapy for head and neck cancers, in patients undergoing bone marrow transplantation and those receiving certain chemotherapeutic agents for a variety of human malignancies. The intent of this paper is to review preventive strategies and treatment approaches for patients with established oral mucositis. Many agents of differing mechanisms of action have been used in the prevention and treatment of oral mucositis induced by anticancer therapies. Currently, no intervention is completely successful at preventing or treating oral mucositis. The several solutions, drugs and methods used and studied in the prophylaxis and therapy of chemotherapy or radiotherapy-induced oral mucositis reflects the need of new, more efficient tools in the management of this complication. Current studies and our increasing understanding of the etiology and pathogenesis of oral mucositis will lead to new approaches to the management and improved quality of life for these patients.

Authors+Show Affiliations

Dipartimento di Medicina Chirurgia e Odontoiatria, Unità di Patologia e Medicina Orale, Università degli Studi, Milan, Italy. federica.demarosi@unimi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12070468

Citation

Demarosi, F, et al. "Prevention and Treatment of Chemo- and Radiotherapy-induced Oral Mucositis." Minerva Stomatologica, vol. 51, no. 5, 2002, pp. 173-86.
Demarosi F, Bez C, Carrassi A. Prevention and treatment of chemo- and radiotherapy-induced oral mucositis. Minerva Stomatol. 2002;51(5):173-86.
Demarosi, F., Bez, C., & Carrassi, A. (2002). Prevention and treatment of chemo- and radiotherapy-induced oral mucositis. Minerva Stomatologica, 51(5), pp. 173-86.
Demarosi F, Bez C, Carrassi A. Prevention and Treatment of Chemo- and Radiotherapy-induced Oral Mucositis. Minerva Stomatol. 2002;51(5):173-86. PubMed PMID: 12070468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention and treatment of chemo- and radiotherapy-induced oral mucositis. AU - Demarosi,F, AU - Bez,C, AU - Carrassi,A, PY - 2002/6/19/pubmed PY - 2002/11/26/medline PY - 2002/6/19/entrez SP - 173 EP - 86 JF - Minerva stomatologica JO - Minerva Stomatol VL - 51 IS - 5 N2 - The administration of many chemo-radiotherapy regimens in patients with cancer may be complicated by toxicities that limit the clinicians' abilities to deliver the most effective doses of active agents. Oral mucositis is a major dose-limiting toxic effect and the most important cause of morbidity in patients undergoing chemo-radiotherapy for head and neck cancers, in patients undergoing bone marrow transplantation and those receiving certain chemotherapeutic agents for a variety of human malignancies. The intent of this paper is to review preventive strategies and treatment approaches for patients with established oral mucositis. Many agents of differing mechanisms of action have been used in the prevention and treatment of oral mucositis induced by anticancer therapies. Currently, no intervention is completely successful at preventing or treating oral mucositis. The several solutions, drugs and methods used and studied in the prophylaxis and therapy of chemotherapy or radiotherapy-induced oral mucositis reflects the need of new, more efficient tools in the management of this complication. Current studies and our increasing understanding of the etiology and pathogenesis of oral mucositis will lead to new approaches to the management and improved quality of life for these patients. SN - 0026-4970 UR - https://www.unboundmedicine.com/medline/citation/12070468/Prevention_and_treatment_of_chemo__and_radiotherapy_induced_oral_mucositis_ L2 - https://medlineplus.gov/radiationtherapy.html DB - PRIME DP - Unbound Medicine ER -