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Changes in skeletal muscle myosin heavy chain isoform content during congestive heart failure.
Eur J Appl Physiol. 2002 Jun; 87(2):182-6.EJ

Abstract

Recent investigations have suggested that changes in contractile protein expression contribute to reductions in skeletal muscle function during congestive heart failure (CHF). Myosin heavy chain (MHC), a major contractile protein, has been shown to undergo alterations in protein isoform expression during CHF. The purpose of this investigation was twofold: (1) to determine whether muscles of the same functional group undergo similar changes in MHC expression, and (2) determine whether the magnitude of alterations in MHC is related to the severity of CHF. Using the rat coronary ligation model, mild and severe forms of CHF were produced and muscles of the plantar flexor group were analyzed. Whole-muscle MHC isoform proportions were not altered in the soleus and white gastrocnemius muscle, however significant increases in the percentage of fast MHC isoforms (7-9% increases in MHC IIx and IIb expression) were found in the red gastrocnemius muscle. In addition, there were significant proportional increases (8%) in MHC type IIb at the expense of MHC type IIx in the plantaris muscle. Many of the changes in the proportions of MHC isoforms were significantly correlated with indices of CHF severity. This indicates that changes in skeletal muscle MHC isoform expression are related to the severity of CHF and suggests that some peripheral skeletal muscles are more susceptible to shifts in MHC expression due to CHF. These changes in MHC isoform expression may contribute to alterations in the physiological performance of skeletal muscle and exercise capacity during CHF.

Authors+Show Affiliations

Muscle Function Laboratory, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA. spangenburge@missouri.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12070630

Citation

Spangenburg, Espen E., et al. "Changes in Skeletal Muscle Myosin Heavy Chain Isoform Content During Congestive Heart Failure." European Journal of Applied Physiology, vol. 87, no. 2, 2002, pp. 182-6.
Spangenburg EE, Talmadge RJ, Musch TI, et al. Changes in skeletal muscle myosin heavy chain isoform content during congestive heart failure. Eur J Appl Physiol. 2002;87(2):182-6.
Spangenburg, E. E., Talmadge, R. J., Musch, T. I., Pfeifer, P. C., McAllister, R. M., & Williams, J. H. (2002). Changes in skeletal muscle myosin heavy chain isoform content during congestive heart failure. European Journal of Applied Physiology, 87(2), 182-6.
Spangenburg EE, et al. Changes in Skeletal Muscle Myosin Heavy Chain Isoform Content During Congestive Heart Failure. Eur J Appl Physiol. 2002;87(2):182-6. PubMed PMID: 12070630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in skeletal muscle myosin heavy chain isoform content during congestive heart failure. AU - Spangenburg,Espen E, AU - Talmadge,Robert J, AU - Musch,Timothy I, AU - Pfeifer,P C, AU - McAllister,Richard M, AU - Williams,Jay H, Y1 - 2002/04/26/ PY - 2002/02/21/accepted PY - 2002/6/19/pubmed PY - 2003/1/23/medline PY - 2002/6/19/entrez SP - 182 EP - 6 JF - European journal of applied physiology JO - Eur J Appl Physiol VL - 87 IS - 2 N2 - Recent investigations have suggested that changes in contractile protein expression contribute to reductions in skeletal muscle function during congestive heart failure (CHF). Myosin heavy chain (MHC), a major contractile protein, has been shown to undergo alterations in protein isoform expression during CHF. The purpose of this investigation was twofold: (1) to determine whether muscles of the same functional group undergo similar changes in MHC expression, and (2) determine whether the magnitude of alterations in MHC is related to the severity of CHF. Using the rat coronary ligation model, mild and severe forms of CHF were produced and muscles of the plantar flexor group were analyzed. Whole-muscle MHC isoform proportions were not altered in the soleus and white gastrocnemius muscle, however significant increases in the percentage of fast MHC isoforms (7-9% increases in MHC IIx and IIb expression) were found in the red gastrocnemius muscle. In addition, there were significant proportional increases (8%) in MHC type IIb at the expense of MHC type IIx in the plantaris muscle. Many of the changes in the proportions of MHC isoforms were significantly correlated with indices of CHF severity. This indicates that changes in skeletal muscle MHC isoform expression are related to the severity of CHF and suggests that some peripheral skeletal muscles are more susceptible to shifts in MHC expression due to CHF. These changes in MHC isoform expression may contribute to alterations in the physiological performance of skeletal muscle and exercise capacity during CHF. SN - 1439-6319 UR - https://www.unboundmedicine.com/medline/citation/12070630/Changes_in_skeletal_muscle_myosin_heavy_chain_isoform_content_during_congestive_heart_failure_ L2 - https://dx.doi.org/10.1007/s00421-002-0615-3 DB - PRIME DP - Unbound Medicine ER -