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Vitamin D insufficiency in a population of healthy western Canadians.
CMAJ. 2002 Jun 11; 166(12):1517-24.CMAJ

Abstract

BACKGROUND

People with low levels of vitamin D and its metabolites are at increased risk for osteoporotic fractures. We wished to ascertain levels of vitamin D in a representative sample of adult western Canadians, to help assess the level of risk. We evaluated the prevalence of vitamin D insufficiency, defined as 25-hydroxyvitamin D [25(OH)D] less than 40 nmol/L, and seasonal variations in 25(OH)D, parathyroid hormone and related biochemical indices in a community-dwelling population of healthy Canadians living in Calgary (latitude 51 degrees 07'N).

METHODS

During calendar year 1999, we collected fasting overnight blood samples every 3 months from 60 men and 128 women (age range 27 to 89 years) who had volunteered to participate in another study. We used commercial radioimmunoassay kits to measure calciotrophic hormones and other biochemical indices. Regression models for longitudinal data were used to assess the effect of season and other potential predictors on individual parameters.

RESULTS

For a total of 64 participants (34%), vitamin D insufficiency, defined as 25(OH)D less than 40 nmol/L, was recorded at least once out of the 4 sampling times. After adjustment for age, body mass index and holiday travel, we observed the anticipated rise in serum 25(OH)D from a mean of 57.3 (standard deviation [SD] 21.3) nmol/L in the winter to 62.9 (SD 28.8) nmol/L in spring (p = 0.001) and 71.6 (SD 23.6) nmol/L in summer (p < 0.001), with a subsequent decline to 52.9 (SD 17.2) nmol/L in the fall (p = 0.008). The anticipated inverse relation between 25(OH)D and parathyroid hormone was not consistently observed: after adjustment for age, sex, body mass index and serum calcium, serum levels of parathyroid hormone did decrease significantly, from 39.5 (SD 18.8) ng/L in winter to 36.3 (SD 17.8) ng/L in summer (p = 0.001), but they continued to decline to 34.5 (SD 17.3) ng/L in the fall (p < 0.001). There was no association between 25(OH)D and parathyroid hormone (p = 0.21).

INTERPRETATION

We documented a high prevalence of vitamin D insufficiency, which warrants consideration of dietary vitamin D supplementation.

Authors+Show Affiliations

Department of Medical Science, University of Calgary, Alta.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12074117

Citation

Rucker, Diana, et al. "Vitamin D Insufficiency in a Population of Healthy Western Canadians." CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, vol. 166, no. 12, 2002, pp. 1517-24.
Rucker D, Allan JA, Fick GH, et al. Vitamin D insufficiency in a population of healthy western Canadians. CMAJ. 2002;166(12):1517-24.
Rucker, D., Allan, J. A., Fick, G. H., & Hanley, D. A. (2002). Vitamin D insufficiency in a population of healthy western Canadians. CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, 166(12), 1517-24.
Rucker D, et al. Vitamin D Insufficiency in a Population of Healthy Western Canadians. CMAJ. 2002 Jun 11;166(12):1517-24. PubMed PMID: 12074117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D insufficiency in a population of healthy western Canadians. AU - Rucker,Diana, AU - Allan,Jane A, AU - Fick,Gordon H, AU - Hanley,David A, PY - 2002/6/21/pubmed PY - 2002/7/10/medline PY - 2002/6/21/entrez SP - 1517 EP - 24 JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne JO - CMAJ VL - 166 IS - 12 N2 - BACKGROUND: People with low levels of vitamin D and its metabolites are at increased risk for osteoporotic fractures. We wished to ascertain levels of vitamin D in a representative sample of adult western Canadians, to help assess the level of risk. We evaluated the prevalence of vitamin D insufficiency, defined as 25-hydroxyvitamin D [25(OH)D] less than 40 nmol/L, and seasonal variations in 25(OH)D, parathyroid hormone and related biochemical indices in a community-dwelling population of healthy Canadians living in Calgary (latitude 51 degrees 07'N). METHODS: During calendar year 1999, we collected fasting overnight blood samples every 3 months from 60 men and 128 women (age range 27 to 89 years) who had volunteered to participate in another study. We used commercial radioimmunoassay kits to measure calciotrophic hormones and other biochemical indices. Regression models for longitudinal data were used to assess the effect of season and other potential predictors on individual parameters. RESULTS: For a total of 64 participants (34%), vitamin D insufficiency, defined as 25(OH)D less than 40 nmol/L, was recorded at least once out of the 4 sampling times. After adjustment for age, body mass index and holiday travel, we observed the anticipated rise in serum 25(OH)D from a mean of 57.3 (standard deviation [SD] 21.3) nmol/L in the winter to 62.9 (SD 28.8) nmol/L in spring (p = 0.001) and 71.6 (SD 23.6) nmol/L in summer (p < 0.001), with a subsequent decline to 52.9 (SD 17.2) nmol/L in the fall (p = 0.008). The anticipated inverse relation between 25(OH)D and parathyroid hormone was not consistently observed: after adjustment for age, sex, body mass index and serum calcium, serum levels of parathyroid hormone did decrease significantly, from 39.5 (SD 18.8) ng/L in winter to 36.3 (SD 17.8) ng/L in summer (p = 0.001), but they continued to decline to 34.5 (SD 17.3) ng/L in the fall (p < 0.001). There was no association between 25(OH)D and parathyroid hormone (p = 0.21). INTERPRETATION: We documented a high prevalence of vitamin D insufficiency, which warrants consideration of dietary vitamin D supplementation. SN - 0820-3946 UR - https://www.unboundmedicine.com/medline/citation/12074117/Vitamin_D_insufficiency_in_a_population_of_healthy_western_Canadians_ L2 - http://www.cmaj.ca/cgi/pmidlookup?view=long&amp;pmid=12074117 DB - PRIME DP - Unbound Medicine ER -