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Monitoring dietary compliance in coeliac disease using red cell distribution width.
Int J Clin Pract. 2002 May; 56(4):249-50.IJ

Abstract

Red cell distribution width (RDW) as measured on modern blood analysers is a sensitive marker of nutritional deficiency affecting red blood cell production and maturation. Such deficiencies are common in coeliac disease and it may therefore be possible indirectly to assess response to a gluten-free diet by monitoring the RDW. We measured RDW, iron, B12, folate and endomysial antibodies (EMA) in 46 newly diagnosed coeliac patients at diagnosis and after a gluten-free diet. RDW was elevated in 76% of patients at diagnosis. There was a significant decrease in RDW (17.3% vs 13.8%) after 12 months of diet, corresponding to sero-conversion of EMA and normalisation of serum iron, B12 and folate levels. We conclude that monitoring RDW is a simple indirect means of assessing response to a gluten-free diet in coeliac disease.

Authors+Show Affiliations

Department of Gastroenterology, Belfast City Hospital.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12074205

Citation

Mitchell, R M S., and T J. Robinson. "Monitoring Dietary Compliance in Coeliac Disease Using Red Cell Distribution Width." International Journal of Clinical Practice, vol. 56, no. 4, 2002, pp. 249-50.
Mitchell RM, Robinson TJ. Monitoring dietary compliance in coeliac disease using red cell distribution width. Int J Clin Pract. 2002;56(4):249-50.
Mitchell, R. M., & Robinson, T. J. (2002). Monitoring dietary compliance in coeliac disease using red cell distribution width. International Journal of Clinical Practice, 56(4), 249-50.
Mitchell RM, Robinson TJ. Monitoring Dietary Compliance in Coeliac Disease Using Red Cell Distribution Width. Int J Clin Pract. 2002;56(4):249-50. PubMed PMID: 12074205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monitoring dietary compliance in coeliac disease using red cell distribution width. AU - Mitchell,R M S, AU - Robinson,T J, PY - 2002/6/21/pubmed PY - 2002/7/18/medline PY - 2002/6/21/entrez SP - 249 EP - 50 JF - International journal of clinical practice JO - Int J Clin Pract VL - 56 IS - 4 N2 - Red cell distribution width (RDW) as measured on modern blood analysers is a sensitive marker of nutritional deficiency affecting red blood cell production and maturation. Such deficiencies are common in coeliac disease and it may therefore be possible indirectly to assess response to a gluten-free diet by monitoring the RDW. We measured RDW, iron, B12, folate and endomysial antibodies (EMA) in 46 newly diagnosed coeliac patients at diagnosis and after a gluten-free diet. RDW was elevated in 76% of patients at diagnosis. There was a significant decrease in RDW (17.3% vs 13.8%) after 12 months of diet, corresponding to sero-conversion of EMA and normalisation of serum iron, B12 and folate levels. We conclude that monitoring RDW is a simple indirect means of assessing response to a gluten-free diet in coeliac disease. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/12074205/Monitoring_dietary_compliance_in_coeliac_disease_using_red_cell_distribution_width_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -