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Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women.
Cancer Causes Control 2002; 13(4):325-32CC

Abstract

OBJECTIVE

Epidemiologic evidence suggests a positive association between body mass, adult height, and postmenopausal breast cancer. However, most studies have not been large enough to examine the association across a very wide range of body mass or height, and few studies have assessed the relationship between body mass or height and postmenopausal breast cancer mortality.

METHODS

The relation between body mass index (BMI) and height and postmenopausal breast cancer mortality was examined in the American Cancer Society's Cancer Prevention Study II (CPS-II), a large prospective mortality study of US adults enrolled in 1982. After 14 years of follow-up, 2852 breast cancer deaths were observed among 424,168 postmenopausal women who were cancer-free at interview. Cox proportional hazards modeling was used to estimate relative risks and to control for potential confounding.

RESULTS

Breast cancer mortality rates increased continually and substantially with increasing BMI (rate ratio (RR) = 3.08, 95% confidence interval (CI) = 2.09-4.51 for BMI > 40.0 compared to BMI 18.5-20.49). If causal, the multivariate-adjusted RR estimates in this study correspond to approximately 30-50% of breast cancer deaths among postmenopausal women in the US population being attributable to overweight. Breast cancer mortality also increased with increasing height up to 66 inches with RR= 1.64, (95% CI = 1.23-2.18) in women 66 inches tall compared to those <60 inches.

CONCLUSIONS

Postmenopausal obesity is an important and potentially avoidable predictor of fatal breast cancer in this study. These results underscore the importance of maintaining moderate weight throughout adult life.

Authors+Show Affiliations

Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12074502

Citation

Petrelli, Jennifer M., et al. "Body Mass Index, Height, and Postmenopausal Breast Cancer Mortality in a Prospective Cohort of US Women." Cancer Causes & Control : CCC, vol. 13, no. 4, 2002, pp. 325-32.
Petrelli JM, Calle EE, Rodriguez C, et al. Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. Cancer Causes Control. 2002;13(4):325-32.
Petrelli, J. M., Calle, E. E., Rodriguez, C., & Thun, M. J. (2002). Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. Cancer Causes & Control : CCC, 13(4), pp. 325-32.
Petrelli JM, et al. Body Mass Index, Height, and Postmenopausal Breast Cancer Mortality in a Prospective Cohort of US Women. Cancer Causes Control. 2002;13(4):325-32. PubMed PMID: 12074502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. AU - Petrelli,Jennifer M, AU - Calle,Eugenia E, AU - Rodriguez,Carmen, AU - Thun,Michael J, PY - 2002/6/21/pubmed PY - 2002/11/26/medline PY - 2002/6/21/entrez SP - 325 EP - 32 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 13 IS - 4 N2 - OBJECTIVE: Epidemiologic evidence suggests a positive association between body mass, adult height, and postmenopausal breast cancer. However, most studies have not been large enough to examine the association across a very wide range of body mass or height, and few studies have assessed the relationship between body mass or height and postmenopausal breast cancer mortality. METHODS: The relation between body mass index (BMI) and height and postmenopausal breast cancer mortality was examined in the American Cancer Society's Cancer Prevention Study II (CPS-II), a large prospective mortality study of US adults enrolled in 1982. After 14 years of follow-up, 2852 breast cancer deaths were observed among 424,168 postmenopausal women who were cancer-free at interview. Cox proportional hazards modeling was used to estimate relative risks and to control for potential confounding. RESULTS: Breast cancer mortality rates increased continually and substantially with increasing BMI (rate ratio (RR) = 3.08, 95% confidence interval (CI) = 2.09-4.51 for BMI > 40.0 compared to BMI 18.5-20.49). If causal, the multivariate-adjusted RR estimates in this study correspond to approximately 30-50% of breast cancer deaths among postmenopausal women in the US population being attributable to overweight. Breast cancer mortality also increased with increasing height up to 66 inches with RR= 1.64, (95% CI = 1.23-2.18) in women 66 inches tall compared to those <60 inches. CONCLUSIONS: Postmenopausal obesity is an important and potentially avoidable predictor of fatal breast cancer in this study. These results underscore the importance of maintaining moderate weight throughout adult life. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/12074502/Body_mass_index_height_and_postmenopausal_breast_cancer_mortality_in_a_prospective_cohort_of_US_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=12074502.ui DB - PRIME DP - Unbound Medicine ER -