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Development of hypertension over 6 years in a birth cohort of young middle-aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS).

Abstract

OBJECTIVES

To explore the development of hypertension (HT) in a cohort of young middle-aged men.

DESIGN

Prospective birth-cohort study of men surveyed over 6 years.

SETTING

Helsingborg County Hospital, Sweden, 1990-97.

SUBJECTS

A total of 628 men born in 1953-54, all surveyed at 37, 40 and 43 years of age.

MAIN OUTCOME MEASURES

Systolic blood pressure (SBP), diastolic blood pressure (DBP), S-cholesterol, body mass index (BMI), alcohol consumption, ethnicity. HT was defined as SBP > or = 140 mmHg and/or DBP > or = 90 mmHg, or ongoing treatment. Using SBP < 130 mmHg and DBP < 85 mmHg as reference, the odds of conversion to HT in men with high normal blood pressure (BP) (SBP 130-139 mmHg and DBP 85-89 mmHg) was investigated.

RESULTS

At age 37, 243 men (39%) had reference BP, 167 (26%) had high normal BP and 218 (35%) were hypertensive. Corresponding numbers at age 40 were 265 (42%), 166 (27%) and 197 (31%); and at age 43, 180 (29%), 142 (22%) and 306 (49%), respectively. High normal BP at baseline was associated with the development of HT both at age 40 (odds ratio (OR)=2.45 confidence interval (CI): 1.42-4.22) and at age 43 (OR=2.46, CI: 1.59-3.80), independent of other cardiovascular disease risk factors and ethnicity. The progression to HT was predicted also by S-cholesterol, alcohol consumption, BMI and weight gain.

CONCLUSIONS

Over a short-term period, a substantial proportion of young middle-aged men with high normal BP develop HT with overweight and alcohol consumption as important determinants. These findings have implications for the prevention, screening and medical care of HT in this target population.

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  • Authors+Show Affiliations

    ,

    Department of Community Medicine, Lund University, Malmö, Sweden. karin.heriksson@smi.mas.lu.se

    , , , ,

    Source

    Journal of internal medicine 252:1 2002 Jul pg 21-6

    MeSH

    Adult
    Alcohol Drinking
    Blood Pressure
    Body Mass Index
    Cholesterol
    Humans
    Hypertension
    Male
    Obesity
    Physical Examination
    Prospective Studies
    Risk Factors
    Smoking
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12074734

    Citation

    Henriksson, K M., et al. "Development of Hypertension Over 6 Years in a Birth Cohort of Young Middle-aged Men: the Cardiovascular Risk Factor Study in Southern Sweden (CRISS)." Journal of Internal Medicine, vol. 252, no. 1, 2002, pp. 21-6.
    Henriksson KM, Lindblad U, Gullberg B, et al. Development of hypertension over 6 years in a birth cohort of young middle-aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS). J Intern Med. 2002;252(1):21-6.
    Henriksson, K. M., Lindblad, U., Gullberg, B., Agren, B., Nilsson-Ehle, P., & Råstam, L. (2002). Development of hypertension over 6 years in a birth cohort of young middle-aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS). Journal of Internal Medicine, 252(1), pp. 21-6.
    Henriksson KM, et al. Development of Hypertension Over 6 Years in a Birth Cohort of Young Middle-aged Men: the Cardiovascular Risk Factor Study in Southern Sweden (CRISS). J Intern Med. 2002;252(1):21-6. PubMed PMID: 12074734.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Development of hypertension over 6 years in a birth cohort of young middle-aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS). AU - Henriksson,K M, AU - Lindblad,U, AU - Gullberg,B, AU - Agren,B, AU - Nilsson-Ehle,P, AU - Råstam,L, PY - 2002/6/21/pubmed PY - 2002/8/14/medline PY - 2002/6/21/entrez SP - 21 EP - 6 JF - Journal of internal medicine JO - J. Intern. Med. VL - 252 IS - 1 N2 - OBJECTIVES: To explore the development of hypertension (HT) in a cohort of young middle-aged men. DESIGN: Prospective birth-cohort study of men surveyed over 6 years. SETTING: Helsingborg County Hospital, Sweden, 1990-97. SUBJECTS: A total of 628 men born in 1953-54, all surveyed at 37, 40 and 43 years of age. MAIN OUTCOME MEASURES: Systolic blood pressure (SBP), diastolic blood pressure (DBP), S-cholesterol, body mass index (BMI), alcohol consumption, ethnicity. HT was defined as SBP > or = 140 mmHg and/or DBP > or = 90 mmHg, or ongoing treatment. Using SBP < 130 mmHg and DBP < 85 mmHg as reference, the odds of conversion to HT in men with high normal blood pressure (BP) (SBP 130-139 mmHg and DBP 85-89 mmHg) was investigated. RESULTS: At age 37, 243 men (39%) had reference BP, 167 (26%) had high normal BP and 218 (35%) were hypertensive. Corresponding numbers at age 40 were 265 (42%), 166 (27%) and 197 (31%); and at age 43, 180 (29%), 142 (22%) and 306 (49%), respectively. High normal BP at baseline was associated with the development of HT both at age 40 (odds ratio (OR)=2.45 confidence interval (CI): 1.42-4.22) and at age 43 (OR=2.46, CI: 1.59-3.80), independent of other cardiovascular disease risk factors and ethnicity. The progression to HT was predicted also by S-cholesterol, alcohol consumption, BMI and weight gain. CONCLUSIONS: Over a short-term period, a substantial proportion of young middle-aged men with high normal BP develop HT with overweight and alcohol consumption as important determinants. These findings have implications for the prevention, screening and medical care of HT in this target population. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/12074734/Development_of_hypertension_over_6_years_in_a_birth_cohort_of_young_middle_aged_men:_the_Cardiovascular_Risk_Factor_Study_in_southern_Sweden__CRISS__ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0954-6820&amp;date=2002&amp;volume=252&amp;issue=1&amp;spage=21 DB - PRIME DP - Unbound Medicine ER -