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Inhibition by wine polyphenols of peroxynitrite-initiated chemiluminescence and NADH oxidation.
Ann N Y Acad Sci. 2002 May; 957:90-102.AN

Abstract

Peroxynitrite (ONOO(-)) is a powerful oxidant produced by neutrophils, macrophages, and lymphocytes as a signaling and cytotoxic molecule from their primary production of nitric oxide (NO) and superoxide anion (O(2)(-)). In the vascular space, ONOO(-) will likely oxidize lipoproteins and promote atherogenesis. Pure wine flavonoids (catechin, epicatechin, myricetin), hydroxycinnamates (caffeic acid, ferulic acid, chlorogenic acid), and plain Argentine red wines were assayed as ONOO(-) scavengers in two assays: (a) ONOO(-)-initiated chemiluminescence and (b) ONOO(-)-dependent oxidation. The assayed polyphenols as well as the red wines were effective inhibitors of the ONOO(-)-driven oxidation reactions. Fifty percent of the pure substances were observed in the range of 30-300 microM and in the case of red wines with the equivalent of 80-120 microM of flavonoids. The amphipatic nature of wine polyphenols will lead to their accumulation at the lipoprotein surface, according to the Gibbs adsorption equation, where they are likely to prevent ONOO(-)-induced tyrosine nitration and LDL modification.

Authors+Show Affiliations

Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. aboveris@ffyb.uba.arNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12074964

Citation

Boveris, Alberto, et al. "Inhibition By Wine Polyphenols of Peroxynitrite-initiated Chemiluminescence and NADH Oxidation." Annals of the New York Academy of Sciences, vol. 957, 2002, pp. 90-102.
Boveris A, Valdez L, Alvarez S. Inhibition by wine polyphenols of peroxynitrite-initiated chemiluminescence and NADH oxidation. Ann N Y Acad Sci. 2002;957:90-102.
Boveris, A., Valdez, L., & Alvarez, S. (2002). Inhibition by wine polyphenols of peroxynitrite-initiated chemiluminescence and NADH oxidation. Annals of the New York Academy of Sciences, 957, 90-102.
Boveris A, Valdez L, Alvarez S. Inhibition By Wine Polyphenols of Peroxynitrite-initiated Chemiluminescence and NADH Oxidation. Ann N Y Acad Sci. 2002;957:90-102. PubMed PMID: 12074964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition by wine polyphenols of peroxynitrite-initiated chemiluminescence and NADH oxidation. AU - Boveris,Alberto, AU - Valdez,Laura, AU - Alvarez,Silvia, PY - 2002/6/21/pubmed PY - 2002/8/1/medline PY - 2002/6/21/entrez SP - 90 EP - 102 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 957 N2 - Peroxynitrite (ONOO(-)) is a powerful oxidant produced by neutrophils, macrophages, and lymphocytes as a signaling and cytotoxic molecule from their primary production of nitric oxide (NO) and superoxide anion (O(2)(-)). In the vascular space, ONOO(-) will likely oxidize lipoproteins and promote atherogenesis. Pure wine flavonoids (catechin, epicatechin, myricetin), hydroxycinnamates (caffeic acid, ferulic acid, chlorogenic acid), and plain Argentine red wines were assayed as ONOO(-) scavengers in two assays: (a) ONOO(-)-initiated chemiluminescence and (b) ONOO(-)-dependent oxidation. The assayed polyphenols as well as the red wines were effective inhibitors of the ONOO(-)-driven oxidation reactions. Fifty percent of the pure substances were observed in the range of 30-300 microM and in the case of red wines with the equivalent of 80-120 microM of flavonoids. The amphipatic nature of wine polyphenols will lead to their accumulation at the lipoprotein surface, according to the Gibbs adsorption equation, where they are likely to prevent ONOO(-)-induced tyrosine nitration and LDL modification. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/12074964/Inhibition_by_wine_polyphenols_of_peroxynitrite_initiated_chemiluminescence_and_NADH_oxidation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2002&volume=957&spage=90 DB - PRIME DP - Unbound Medicine ER -