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Antibacterial activity of oral antibiotics against community-acquired respiratory pathogens from three European countries.
J Antimicrob Chemother. 2002 Jul; 50 Suppl:7-11.JA

Abstract

Antimicrobial resistance is universally recognized as a major problem. A European resistance survey was established to monitor the activity of widely used oral antibiotics against common respiratory tract pathogens. Studies were conducted in Italy, Spain and Austria to monitor resistance patterns among respiratory Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus aureus and Klebsiella pneumoniae to amoxicillin, co-amoxiclav, penicillin, cefaclor, cefadroxil, cefalexin, cefprozil, cefuroxime, cefixime, ceftibuten, cefpodoxime, clarithromycin and azithromycin (the antibiotics tested varying slightly from country to country). Minimum inhibitory concentrations were determined using the NCCLS-recommended broth microdilution method. Among the antibiotics tested, cefpodoxime, an oral cephalosporin, was remarkably active against the major respiratory pathogens in all three countries. Cefpodoxime was more potent than cefaclor, cefixime and ceftibuten against pneumococci, especially against strains with decreased sensitivity to penicillin, and more active than cefaclor and cefuroxime against Gram-negative respiratory pathogens. Pneumococci and staphylococci displayed a very high level of in vitro macrolide resistance. These data indicate that cefpodoxime represents an appropriate choice in the treatment of community-acquired respiratory tract infection in the three countries surveyed.

Authors+Show Affiliations

Institute of Microbiology, Medical School, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy. schitogc@aleph.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12077154

Citation

Schito, Gian Carlo, et al. "Antibacterial Activity of Oral Antibiotics Against Community-acquired Respiratory Pathogens From Three European Countries." The Journal of Antimicrobial Chemotherapy, vol. 50 Suppl, 2002, pp. 7-11.
Schito GC, Georgopoulos A, Prieto J. Antibacterial activity of oral antibiotics against community-acquired respiratory pathogens from three European countries. J Antimicrob Chemother. 2002;50 Suppl:7-11.
Schito, G. C., Georgopoulos, A., & Prieto, J. (2002). Antibacterial activity of oral antibiotics against community-acquired respiratory pathogens from three European countries. The Journal of Antimicrobial Chemotherapy, 50 Suppl, 7-11.
Schito GC, Georgopoulos A, Prieto J. Antibacterial Activity of Oral Antibiotics Against Community-acquired Respiratory Pathogens From Three European Countries. J Antimicrob Chemother. 2002;50 Suppl:7-11. PubMed PMID: 12077154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity of oral antibiotics against community-acquired respiratory pathogens from three European countries. AU - Schito,Gian Carlo, AU - Georgopoulos,Apostolos, AU - Prieto,José, PY - 2002/6/22/pubmed PY - 2003/2/14/medline PY - 2002/6/22/entrez SP - 7 EP - 11 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 50 Suppl N2 - Antimicrobial resistance is universally recognized as a major problem. A European resistance survey was established to monitor the activity of widely used oral antibiotics against common respiratory tract pathogens. Studies were conducted in Italy, Spain and Austria to monitor resistance patterns among respiratory Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus aureus and Klebsiella pneumoniae to amoxicillin, co-amoxiclav, penicillin, cefaclor, cefadroxil, cefalexin, cefprozil, cefuroxime, cefixime, ceftibuten, cefpodoxime, clarithromycin and azithromycin (the antibiotics tested varying slightly from country to country). Minimum inhibitory concentrations were determined using the NCCLS-recommended broth microdilution method. Among the antibiotics tested, cefpodoxime, an oral cephalosporin, was remarkably active against the major respiratory pathogens in all three countries. Cefpodoxime was more potent than cefaclor, cefixime and ceftibuten against pneumococci, especially against strains with decreased sensitivity to penicillin, and more active than cefaclor and cefuroxime against Gram-negative respiratory pathogens. Pneumococci and staphylococci displayed a very high level of in vitro macrolide resistance. These data indicate that cefpodoxime represents an appropriate choice in the treatment of community-acquired respiratory tract infection in the three countries surveyed. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/12077154/Antibacterial_activity_of_oral_antibiotics_against_community_acquired_respiratory_pathogens_from_three_European_countries_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkf802 DB - PRIME DP - Unbound Medicine ER -