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TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Nature. 2002 Jul 11; 418(6894):186-90.Nat

Abstract

Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Although VR1 gene disruption results in a loss of capsaicin responses, it has minimal effects on thermal nociception. This and other experiments--such as those showing the existence of capsaicin-insensitive heat sensors in sensory neurons--suggest the existence of thermosensitive receptors distinct from VR1. Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive. VRL3 is coded for by a 2,370-base-pair open reading frame, transcribed from a gene adjacent to VR1, and is structurally homologous to VR1. VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1. Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses. Hence, not only is VRL3 a thermosensitive ion channel but it may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels.

Authors+Show Affiliations

Neurology-CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12077606

Citation

Smith, G D., et al. "TRPV3 Is a Temperature-sensitive Vanilloid Receptor-like Protein." Nature, vol. 418, no. 6894, 2002, pp. 186-90.
Smith GD, Gunthorpe MJ, Kelsell RE, et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 2002;418(6894):186-90.
Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., Wright, J. E., Jerman, J. C., Walhin, J. P., Ooi, L., Egerton, J., Charles, K. J., Smart, D., Randall, A. D., Anand, P., & Davis, J. B. (2002). TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418(6894), 186-90.
Smith GD, et al. TRPV3 Is a Temperature-sensitive Vanilloid Receptor-like Protein. Nature. 2002 Jul 11;418(6894):186-90. PubMed PMID: 12077606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRPV3 is a temperature-sensitive vanilloid receptor-like protein. AU - Smith,G D, AU - Gunthorpe,M J, AU - Kelsell,R E, AU - Hayes,P D, AU - Reilly,P, AU - Facer,P, AU - Wright,J E, AU - Jerman,J C, AU - Walhin,J-P, AU - Ooi,L, AU - Egerton,J, AU - Charles,K J, AU - Smart,D, AU - Randall,A D, AU - Anand,P, AU - Davis,J B, Y1 - 2002/06/23/ PY - 2002/6/22/pubmed PY - 2002/8/1/medline PY - 2002/6/22/entrez SP - 186 EP - 90 JF - Nature JO - Nature VL - 418 IS - 6894 N2 - Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Although VR1 gene disruption results in a loss of capsaicin responses, it has minimal effects on thermal nociception. This and other experiments--such as those showing the existence of capsaicin-insensitive heat sensors in sensory neurons--suggest the existence of thermosensitive receptors distinct from VR1. Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive. VRL3 is coded for by a 2,370-base-pair open reading frame, transcribed from a gene adjacent to VR1, and is structurally homologous to VR1. VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1. Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses. Hence, not only is VRL3 a thermosensitive ion channel but it may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/12077606/TRPV3_is_a_temperature_sensitive_vanilloid_receptor_like_protein_ L2 - https://doi.org/10.1038/nature00894 DB - PRIME DP - Unbound Medicine ER -