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Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men.
Metabolism 2002; 51(7):819-26M

Abstract

Low-glycemic index diets are associated with a wide range of benefits when followed on a chronic basis. The chronic effects, however, of the substitution of 1 meal per day are not well known in diabetic subjects. Therefore, we aimed to evaluate whether the chronic use of a low-glycemic index breakfast (low-GIB) rich in low-GI carbohydrates and a modest amount of soluble fibers could have an effect on lipemia at a subsequent lunch, and improve glucose and lipid metabolism in men with type 2 diabetes. A total of 13 men with type 2 diabetes were randomly allocated in a double-blind cross-over design to a 4-week daily intake of a low-GI versus a high-GI breakfast separated by a 15-day washout interval. The low-GI breakfast was composed of whole grain bread and muesli containing 3 g beta-glucan from oats. Low-GIB induced lower postprandial plasma glucose peaks than the high-GIB at the beginning (baseline, P <.001) and after the 4-week intake (P <.001). The incremental area under the plasma glucose curve was also lower (P <.001, P <.01, baseline, and 4 weeks, respectively). There was no effect on fasting plasma glucose, insulin, fructosamine, or glycosylated hemoglobin (HbA(1c)). Fasting plasma cholesterol, as well as the incremental area under the cholesterol curve, were lower (P <.03, P <.02) after the 4-week low-GIB period than after the high-GIB period. Apolipoprotein B (apo B) was also decreased by the 4-week low-GIB. There was no effect of the low-GI breakfast on triacylglycerol excursions or glucose and insulin responses at the second meal. The high-GIB, however, tended to decrease the amount of mRNA of leptin in abdominal adipose tissue, but had no effect on peroxisome proliferator-activated receptor gamma (PPARgamma) and cholesterylester transfer protein (CETP) mRNA amounts. In conclusion, the intake of a low-GI breakfast containing a modest amount (3 g) of beta-glucan for 4 weeks allowed good glycemic control and induced low plasma cholesterol levels in men with type 2 diabetes. The decrease in plasma cholesterol associated with low-GI breakfast intake may reduce the risk of developing cardiovascular complications in subjects with type 2 diabetes.

Authors+Show Affiliations

INSERM U341 Department of Diabetes, A.P. Hôtel-Dieu Hospital, EA 3502 University Paris, VI, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12077724

Citation

Kabir, Morvarid, et al. "Four-week Low-glycemic Index Breakfast With a Modest Amount of Soluble Fibers in Type 2 Diabetic Men." Metabolism: Clinical and Experimental, vol. 51, no. 7, 2002, pp. 819-26.
Kabir M, Oppert JM, Vidal H, et al. Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. Metab Clin Exp. 2002;51(7):819-26.
Kabir, M., Oppert, J. M., Vidal, H., Bruzzo, F., Fiquet, C., Wursch, P., ... Rizkalla, S. W. (2002). Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. Metabolism: Clinical and Experimental, 51(7), pp. 819-26.
Kabir M, et al. Four-week Low-glycemic Index Breakfast With a Modest Amount of Soluble Fibers in Type 2 Diabetic Men. Metab Clin Exp. 2002;51(7):819-26. PubMed PMID: 12077724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. AU - Kabir,Morvarid, AU - Oppert,Jean-Michel, AU - Vidal,Hubert, AU - Bruzzo,Francoise, AU - Fiquet,Caroline, AU - Wursch,Pierre, AU - Slama,Gerard, AU - Rizkalla,Salwa W, PY - 2002/6/22/pubmed PY - 2002/7/23/medline PY - 2002/6/22/entrez SP - 819 EP - 26 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 51 IS - 7 N2 - Low-glycemic index diets are associated with a wide range of benefits when followed on a chronic basis. The chronic effects, however, of the substitution of 1 meal per day are not well known in diabetic subjects. Therefore, we aimed to evaluate whether the chronic use of a low-glycemic index breakfast (low-GIB) rich in low-GI carbohydrates and a modest amount of soluble fibers could have an effect on lipemia at a subsequent lunch, and improve glucose and lipid metabolism in men with type 2 diabetes. A total of 13 men with type 2 diabetes were randomly allocated in a double-blind cross-over design to a 4-week daily intake of a low-GI versus a high-GI breakfast separated by a 15-day washout interval. The low-GI breakfast was composed of whole grain bread and muesli containing 3 g beta-glucan from oats. Low-GIB induced lower postprandial plasma glucose peaks than the high-GIB at the beginning (baseline, P <.001) and after the 4-week intake (P <.001). The incremental area under the plasma glucose curve was also lower (P <.001, P <.01, baseline, and 4 weeks, respectively). There was no effect on fasting plasma glucose, insulin, fructosamine, or glycosylated hemoglobin (HbA(1c)). Fasting plasma cholesterol, as well as the incremental area under the cholesterol curve, were lower (P <.03, P <.02) after the 4-week low-GIB period than after the high-GIB period. Apolipoprotein B (apo B) was also decreased by the 4-week low-GIB. There was no effect of the low-GI breakfast on triacylglycerol excursions or glucose and insulin responses at the second meal. The high-GIB, however, tended to decrease the amount of mRNA of leptin in abdominal adipose tissue, but had no effect on peroxisome proliferator-activated receptor gamma (PPARgamma) and cholesterylester transfer protein (CETP) mRNA amounts. In conclusion, the intake of a low-GI breakfast containing a modest amount (3 g) of beta-glucan for 4 weeks allowed good glycemic control and induced low plasma cholesterol levels in men with type 2 diabetes. The decrease in plasma cholesterol associated with low-GI breakfast intake may reduce the risk of developing cardiovascular complications in subjects with type 2 diabetes. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/12077724/Four_week_low_glycemic_index_breakfast_with_a_modest_amount_of_soluble_fibers_in_type_2_diabetic_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049502000021 DB - PRIME DP - Unbound Medicine ER -