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Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers.

Abstract

OBJECTIVE

To study the association between dietary and serum antioxidant vitamins and carotenoids and risk for colorectal cancer in male smokers.

DESIGN

A prospective cohort study within a randomised, double-blind, placebo-controlled trial testing supplementation with alpha-tocopherol (50 mg/day), beta-carotene (20 mg/day) or both in preventing cancer.

SUBJECTS AND METHODS

Participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study with complete dietary data and serum samples available from baseline. These included 26,951 middle-aged male smokers among whom 184 colorectal cancer cases were diagnosed during 8 y of follow-up. Relative risks were calculated with Cox proportional hazards models adjusting for trial supplementation, age, body mass index, serum cholesterol, cigarettes smoked per day and physical activity.

RESULTS

There was no significant association between dietary vitamin C or E, alpha-or gamma-tocopherol, retinol, alpha- or beta-carotene, lycopene or lutein+zeaxanthin and risk for colorectal cancer. Serum alpha-tocopherol, beta-carotene or retinol was also not associated with the risk, neither did the season when baseline blood was drawn modify the relationship between serum beta-carotene and colorectal cancer risk.

CONCLUSIONS

Our data support the results from previous studies in which no association between dietary antioxidant vitamins and carotenoids and risk for colorectal cancer has been observed. Likewise, no association between baseline serum antioxidant concentrations and colorectal cancer risk was evident.

SPONSORSHIP

The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study was supported by a contract with the US National Cancer Institute (N01-CN-45165).

Links

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  • Authors+Show Affiliations

    ,

    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland. nea.malila@cancer.fi

    , , , ,

    Source

    MeSH

    Aged
    Anticarcinogenic Agents
    Antioxidants
    Cohort Studies
    Colorectal Neoplasms
    Dietary Supplements
    Double-Blind Method
    Humans
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Smoking
    Vitamin A
    alpha-Tocopherol
    beta Carotene

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12080400

    Citation

    Malila, N, et al. "Dietary and Serum Alpha-tocopherol, Beta-carotene and Retinol, and Risk for Colorectal Cancer in Male Smokers." European Journal of Clinical Nutrition, vol. 56, no. 7, 2002, pp. 615-21.
    Malila N, Virtamo J, Virtanen M, et al. Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Eur J Clin Nutr. 2002;56(7):615-21.
    Malila, N., Virtamo, J., Virtanen, M., Pietinen, P., Albanes, D., & Teppo, L. (2002). Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. European Journal of Clinical Nutrition, 56(7), pp. 615-21.
    Malila N, et al. Dietary and Serum Alpha-tocopherol, Beta-carotene and Retinol, and Risk for Colorectal Cancer in Male Smokers. Eur J Clin Nutr. 2002;56(7):615-21. PubMed PMID: 12080400.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. AU - Malila,N, AU - Virtamo,J, AU - Virtanen,M, AU - Pietinen,P, AU - Albanes,D, AU - Teppo,L, PY - 2001/04/14/received PY - 2001/10/15/revised PY - 2001/10/17/accepted PY - 2002/6/25/pubmed PY - 2002/10/31/medline PY - 2002/6/25/entrez SP - 615 EP - 21 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 IS - 7 N2 - OBJECTIVE: To study the association between dietary and serum antioxidant vitamins and carotenoids and risk for colorectal cancer in male smokers. DESIGN: A prospective cohort study within a randomised, double-blind, placebo-controlled trial testing supplementation with alpha-tocopherol (50 mg/day), beta-carotene (20 mg/day) or both in preventing cancer. SUBJECTS AND METHODS: Participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study with complete dietary data and serum samples available from baseline. These included 26,951 middle-aged male smokers among whom 184 colorectal cancer cases were diagnosed during 8 y of follow-up. Relative risks were calculated with Cox proportional hazards models adjusting for trial supplementation, age, body mass index, serum cholesterol, cigarettes smoked per day and physical activity. RESULTS: There was no significant association between dietary vitamin C or E, alpha-or gamma-tocopherol, retinol, alpha- or beta-carotene, lycopene or lutein+zeaxanthin and risk for colorectal cancer. Serum alpha-tocopherol, beta-carotene or retinol was also not associated with the risk, neither did the season when baseline blood was drawn modify the relationship between serum beta-carotene and colorectal cancer risk. CONCLUSIONS: Our data support the results from previous studies in which no association between dietary antioxidant vitamins and carotenoids and risk for colorectal cancer has been observed. Likewise, no association between baseline serum antioxidant concentrations and colorectal cancer risk was evident. SPONSORSHIP: The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study was supported by a contract with the US National Cancer Institute (N01-CN-45165). SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12080400/Dietary_and_serum_alpha_tocopherol_beta_carotene_and_retinol_and_risk_for_colorectal_cancer_in_male_smokers_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601366 DB - PRIME DP - Unbound Medicine ER -