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Serum lipid profiles in Japanese women and men during consumption of walnuts.
Eur J Clin Nutr. 2002 Jul; 56(7):629-37.EJ

Abstract

OBJECTIVE

To determine the serum cholesterol, apolipoproteins and LDL oxidizability in young Japanese women and men during walnut consumption and to evaluate its active principle.

DESIGN

Experimental study with a randomized design.

SUBJECTS

Twenty healthy women and 20 healthy men.

INTERVENTIONS

Subjects were randomly assigned to consume each of two mixed natural diets for 4 weeks in a cross-over design. Reference and walnut diets were designed and the walnut diet had 12.5% of the energy derived from walnuts (44-58 g/day).

RESULTS

The total cholesterol and serum apolipoprotein B concentrations, and the ratio of LDL cholesterol to HDL cholesterol was significantly lowered in women and men when fed on the walnut diet, than when on the reference diet (P<or=0.05). The LDL cholesterol concentration was significantly lowered in women on the walnut diet (0.22 mmol/l, P=0.0008), whereas this decrease was not significant in men (0.18 mmol/l, P=0.078). The most prominent change in the fatty acid composition of the cholesteryl esters from serum after the walnut diet was an elevation of alpha-linolenic acid in women (76%, P<0.001) and men (107%, P<0.001). This elevation was negatively correlated to the change in LDL cholesterol in women (r=0.496, P=0.019) and men (r=0.326, P=0.138). The LDL oxidizability in women was not influenced by the diets (P=0.19).

CONCLUSIONS

alpha-Linolenic acid in the walnut diet appears to be responsible for the lowering of LDL cholesterol in women.

SPONSORSHIP

Kyushu University (Fukuoka, Japan) and the California Walnut Commission (California, USA).

Authors+Show Affiliations

Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12080402

Citation

Iwamoto, M, et al. "Serum Lipid Profiles in Japanese Women and Men During Consumption of Walnuts." European Journal of Clinical Nutrition, vol. 56, no. 7, 2002, pp. 629-37.
Iwamoto M, Imaizumi K, Sato M, et al. Serum lipid profiles in Japanese women and men during consumption of walnuts. Eur J Clin Nutr. 2002;56(7):629-37.
Iwamoto, M., Imaizumi, K., Sato, M., Hirooka, Y., Sakai, K., Takeshita, A., & Kono, M. (2002). Serum lipid profiles in Japanese women and men during consumption of walnuts. European Journal of Clinical Nutrition, 56(7), 629-37.
Iwamoto M, et al. Serum Lipid Profiles in Japanese Women and Men During Consumption of Walnuts. Eur J Clin Nutr. 2002;56(7):629-37. PubMed PMID: 12080402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipid profiles in Japanese women and men during consumption of walnuts. AU - Iwamoto,M, AU - Imaizumi,K, AU - Sato,M, AU - Hirooka,Y, AU - Sakai,K, AU - Takeshita,A, AU - Kono,M, PY - 2001/05/14/received PY - 2001/11/30/revised PY - 2001/12/03/accepted PY - 2002/6/25/pubmed PY - 2002/10/31/medline PY - 2002/6/25/entrez SP - 629 EP - 37 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 IS - 7 N2 - OBJECTIVE: To determine the serum cholesterol, apolipoproteins and LDL oxidizability in young Japanese women and men during walnut consumption and to evaluate its active principle. DESIGN: Experimental study with a randomized design. SUBJECTS: Twenty healthy women and 20 healthy men. INTERVENTIONS: Subjects were randomly assigned to consume each of two mixed natural diets for 4 weeks in a cross-over design. Reference and walnut diets were designed and the walnut diet had 12.5% of the energy derived from walnuts (44-58 g/day). RESULTS: The total cholesterol and serum apolipoprotein B concentrations, and the ratio of LDL cholesterol to HDL cholesterol was significantly lowered in women and men when fed on the walnut diet, than when on the reference diet (P<or=0.05). The LDL cholesterol concentration was significantly lowered in women on the walnut diet (0.22 mmol/l, P=0.0008), whereas this decrease was not significant in men (0.18 mmol/l, P=0.078). The most prominent change in the fatty acid composition of the cholesteryl esters from serum after the walnut diet was an elevation of alpha-linolenic acid in women (76%, P<0.001) and men (107%, P<0.001). This elevation was negatively correlated to the change in LDL cholesterol in women (r=0.496, P=0.019) and men (r=0.326, P=0.138). The LDL oxidizability in women was not influenced by the diets (P=0.19). CONCLUSIONS: alpha-Linolenic acid in the walnut diet appears to be responsible for the lowering of LDL cholesterol in women. SPONSORSHIP: Kyushu University (Fukuoka, Japan) and the California Walnut Commission (California, USA). SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12080402/Serum_lipid_profiles_in_Japanese_women_and_men_during_consumption_of_walnuts_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601400 DB - PRIME DP - Unbound Medicine ER -