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Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries.

Abstract

OBJECTIVE

To investigate the relation of baseline antioxidant, fruit, vegetable and fish intake with 20 y chronic obstructive pulmonary disease (COPD) mortality in middle-aged men from three European countries.

DESIGN

Prospective study (1970-1990).

SETTING

Five population-based cohorts of middle-aged men from Finland, Italy and The Netherlands.

SUBJECTS

A total of 2917 men aged 50-69 y at baseline.

METHODS

Baseline information on diet was collected using the cross-check dietary history method. After 20 y of follow-up the underlying cause of death of those who died was established centrally. Survival analyses were performed using the Cox Proportional Hazards Model.

RESULTS

After adjustment for age, smoking and country, we observed an inverse trend (P-trend <0.05) of 20 y COPD mortality across tertiles of fruit and vitamin E intake. No trend was observed for vegetables, fish, vitamin C and beta-carotene. When modelled continuously, a 100 g increase in fruit intake was associated with a 24% lower COPD mortality risk (RR=0.76, 95% CI=0.60-0.92). For vitamin E intake (per 5 mg) the RR was 0.77 (95% CI=0.55-1.06), after adjustment for age, smoking and country. Additional adjustment for body mass index, total energy intake and alcohol consumption reduced the RR to 0.86 (95% CI=0.69-1.07, P=0.12) for fruit and 0.93 (95% CI=0.65-1.33) for vitamin E.

CONCLUSIONS

Our results suggest a protective effect of fruit and possibly vitamin E intake against COPD. No effect was observed for intake of vitamin C, beta-carotene, vegetables and fish.

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  • Authors+Show Affiliations

    ,

    Department of Chronic Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

    , , , , , , ,

    Source

    MeSH

    Adult
    Antioxidants
    Cause of Death
    Cohort Studies
    Diet
    Diet Surveys
    Energy Intake
    Finland
    Fruit
    Humans
    Italy
    Longitudinal Studies
    Male
    Middle Aged
    Netherlands
    Proportional Hazards Models
    Prospective Studies
    Pulmonary Disease, Chronic Obstructive
    Seafood
    Smoking
    Survival Analysis
    Vegetables
    Vitamin E

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12080403

    Citation

    Walda, I C., et al. "Diet and 20-year Chronic Obstructive Pulmonary Disease Mortality in Middle-aged Men From Three European Countries." European Journal of Clinical Nutrition, vol. 56, no. 7, 2002, pp. 638-43.
    Walda IC, Tabak C, Smit HA, et al. Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries. Eur J Clin Nutr. 2002;56(7):638-43.
    Walda, I. C., Tabak, C., Smit, H. A., Räsänen, L., Fidanza, F., Menotti, A., ... Kromhout, D. (2002). Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries. European Journal of Clinical Nutrition, 56(7), pp. 638-43.
    Walda IC, et al. Diet and 20-year Chronic Obstructive Pulmonary Disease Mortality in Middle-aged Men From Three European Countries. Eur J Clin Nutr. 2002;56(7):638-43. PubMed PMID: 12080403.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries. AU - Walda,I C, AU - Tabak,C, AU - Smit,H A, AU - Räsänen,L, AU - Fidanza,F, AU - Menotti,A, AU - Nissinen,A, AU - Feskens,E J M, AU - Kromhout,D, PY - 2001/01/22/received PY - 2001/10/29/revised PY - 2001/10/30/accepted PY - 2002/6/25/pubmed PY - 2002/10/31/medline PY - 2002/6/25/entrez SP - 638 EP - 43 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 IS - 7 N2 - OBJECTIVE: To investigate the relation of baseline antioxidant, fruit, vegetable and fish intake with 20 y chronic obstructive pulmonary disease (COPD) mortality in middle-aged men from three European countries. DESIGN: Prospective study (1970-1990). SETTING: Five population-based cohorts of middle-aged men from Finland, Italy and The Netherlands. SUBJECTS: A total of 2917 men aged 50-69 y at baseline. METHODS: Baseline information on diet was collected using the cross-check dietary history method. After 20 y of follow-up the underlying cause of death of those who died was established centrally. Survival analyses were performed using the Cox Proportional Hazards Model. RESULTS: After adjustment for age, smoking and country, we observed an inverse trend (P-trend <0.05) of 20 y COPD mortality across tertiles of fruit and vitamin E intake. No trend was observed for vegetables, fish, vitamin C and beta-carotene. When modelled continuously, a 100 g increase in fruit intake was associated with a 24% lower COPD mortality risk (RR=0.76, 95% CI=0.60-0.92). For vitamin E intake (per 5 mg) the RR was 0.77 (95% CI=0.55-1.06), after adjustment for age, smoking and country. Additional adjustment for body mass index, total energy intake and alcohol consumption reduced the RR to 0.86 (95% CI=0.69-1.07, P=0.12) for fruit and 0.93 (95% CI=0.65-1.33) for vitamin E. CONCLUSIONS: Our results suggest a protective effect of fruit and possibly vitamin E intake against COPD. No effect was observed for intake of vitamin C, beta-carotene, vegetables and fish. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12080403/Diet_and_20_year_chronic_obstructive_pulmonary_disease_mortality_in_middle_aged_men_from_three_European_countries_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601370 DB - PRIME DP - Unbound Medicine ER -