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Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen.
Eur J Neurosci. 2002 Jun; 15(11):1803-9.EJ

Abstract

Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraine patients a delayed attack of unknown mechanism. After puberty migraine is more prevalent in women. Attacks can be triggered by abrupt falls in plasma estrogen levels, which accounts in part for sexual dimorphism, but lacks an established neurobiological explanation. We studied the effect of nitroglycerin on the innervated area of calcitonin gene-related peptide (CGRP) and serotonin-immunoreactive afferents to the superficial laminae of the spinal portion of trigeminal nucleus caudalis, and its modulation by estrogen. In male rats, nitroglycerin produced after 4 h a significant decrease of the area innervated by CGRP-immunoreactive afferents and an increase of that covered by serotonin-immunoreactive fibres. These effects were not observed in the superficial laminae of thoracic dorsal horns. The effect of nitroglycerin was similar in ovariectomized females. In estradiol-treated ovariectomized females the area in the spinal portion of trigeminal nucleus caudalis laminae I-II covered by CGRP-immunoreactive fibres was lower and that of serotonin-immunoreactive fibres was higher than in males and for both transmitters not significantly changed after nitroglycerin. The bouton size of CGRP profiles was smaller in estradiol-treated ovariectomized females, whereas after nitroglycerin it decreased significantly but only in males and ovariectomized females. Nitroglycerin, i.e. nitric oxide, is thus able to differentially influence afferent fibres in the superficial laminae of rat spinal trigeminal nucleus caudalis. Estradiol modulates the basal expression of these transmitters and blocks the nitroglycerin effect. These data may contribute to understanding the mechanisms by which estrogens influence migraine severity and the triggering of attacks by nitric oxide.

Authors+Show Affiliations

Research Center for Cellular & Molecular Neurobiology, Neuroanatomy & Physiology Laboratories, University of Liège, 20, rue de Pitteurs, B-4020 Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12081660

Citation

Pardutz, A, et al. "Effect of Systemic Nitroglycerin On CGRP and 5-HT Afferents to Rat Caudal Spinal Trigeminal Nucleus and Its Modulation By Estrogen." The European Journal of Neuroscience, vol. 15, no. 11, 2002, pp. 1803-9.
Pardutz A, Multon S, Malgrange B, et al. Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen. Eur J Neurosci. 2002;15(11):1803-9.
Pardutz, A., Multon, S., Malgrange, B., Parducz, A., Vecsei, L., & Schoenen, J. (2002). Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen. The European Journal of Neuroscience, 15(11), 1803-9.
Pardutz A, et al. Effect of Systemic Nitroglycerin On CGRP and 5-HT Afferents to Rat Caudal Spinal Trigeminal Nucleus and Its Modulation By Estrogen. Eur J Neurosci. 2002;15(11):1803-9. PubMed PMID: 12081660.
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TY - JOUR T1 - Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen. AU - Pardutz,A, AU - Multon,S, AU - Malgrange,B, AU - Parducz,A, AU - Vecsei,L, AU - Schoenen,J, PY - 2002/6/26/pubmed PY - 2002/9/6/medline PY - 2002/6/26/entrez SP - 1803 EP - 9 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 15 IS - 11 N2 - Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraine patients a delayed attack of unknown mechanism. After puberty migraine is more prevalent in women. Attacks can be triggered by abrupt falls in plasma estrogen levels, which accounts in part for sexual dimorphism, but lacks an established neurobiological explanation. We studied the effect of nitroglycerin on the innervated area of calcitonin gene-related peptide (CGRP) and serotonin-immunoreactive afferents to the superficial laminae of the spinal portion of trigeminal nucleus caudalis, and its modulation by estrogen. In male rats, nitroglycerin produced after 4 h a significant decrease of the area innervated by CGRP-immunoreactive afferents and an increase of that covered by serotonin-immunoreactive fibres. These effects were not observed in the superficial laminae of thoracic dorsal horns. The effect of nitroglycerin was similar in ovariectomized females. In estradiol-treated ovariectomized females the area in the spinal portion of trigeminal nucleus caudalis laminae I-II covered by CGRP-immunoreactive fibres was lower and that of serotonin-immunoreactive fibres was higher than in males and for both transmitters not significantly changed after nitroglycerin. The bouton size of CGRP profiles was smaller in estradiol-treated ovariectomized females, whereas after nitroglycerin it decreased significantly but only in males and ovariectomized females. Nitroglycerin, i.e. nitric oxide, is thus able to differentially influence afferent fibres in the superficial laminae of rat spinal trigeminal nucleus caudalis. Estradiol modulates the basal expression of these transmitters and blocks the nitroglycerin effect. These data may contribute to understanding the mechanisms by which estrogens influence migraine severity and the triggering of attacks by nitric oxide. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/12081660/Effect_of_systemic_nitroglycerin_on_CGRP_and_5_HT_afferents_to_rat_caudal_spinal_trigeminal_nucleus_and_its_modulation_by_estrogen_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2002&volume=15&issue=11&spage=1803 DB - PRIME DP - Unbound Medicine ER -