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Glucose and insulin responses to dietary chromium supplements: a meta-analysis.
Am J Clin Nutr 2002; 76(1):148-55AJ

Abstract

BACKGROUND

Several authors, mostly on the basis of nonrandomized studies, have suggested dietary trivalent chromium supplementation as an attractive option for the management of type 2 diabetes and for glycemic control in persons at high risk of type 2 diabetes.

OBJECTIVE

The study aimed to determine the effect of chromium on glucose and insulin responses in healthy subjects and in individuals with glucose intolerance or type 2 diabetes.

DESIGN

The study design was a systematic review and meta-analysis of randomized clinical trials (RCTs).

RESULTS

The authors identified 20 reports of RCTs assessing the effect of chromium on glucose, insulin, or glycated hemoglobin (Hb A(1c)). This review summarizes data on 618 participants from the 15 trials that reported adequate data: 193 participants had type 2 diabetes and 425 were in good health or had impaired glucose tolerance. The meta-analysis showed no association between chromium and glucose or insulin concentrations among nondiabetic subjects. A study of 155 diabetic subjects in China showed that chromium reduced glucose and insulin concentrations; the combined data from the 38 diabetic subjects in the other studies did not. Three trials reported data on Hb A(1c): one study each of persons with type 2 diabetes, persons with impaired glucose tolerance, and healthy subjects. The study of diabetic subjects in China was the only one to report that chromium significantly reduced Hb A(1c).

CONCLUSIONS

Data from RCTs show no effect of chromium on glucose or insulin concentrations in nondiabetic subjects. The data for persons with diabetes are inconclusive. RCTs in well-characterized, at-risk populations are necessary to determine the effects of chromium on glucose, insulin, and Hb A(1c).

Authors+Show Affiliations

Statistics Collaborative, Inc, Washington, DC, USA. althuism@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

12081828

Citation

Althuis, Michelle D., et al. "Glucose and Insulin Responses to Dietary Chromium Supplements: a Meta-analysis." The American Journal of Clinical Nutrition, vol. 76, no. 1, 2002, pp. 148-55.
Althuis MD, Jordan NE, Ludington EA, et al. Glucose and insulin responses to dietary chromium supplements: a meta-analysis. Am J Clin Nutr. 2002;76(1):148-55.
Althuis, M. D., Jordan, N. E., Ludington, E. A., & Wittes, J. T. (2002). Glucose and insulin responses to dietary chromium supplements: a meta-analysis. The American Journal of Clinical Nutrition, 76(1), pp. 148-55.
Althuis MD, et al. Glucose and Insulin Responses to Dietary Chromium Supplements: a Meta-analysis. Am J Clin Nutr. 2002;76(1):148-55. PubMed PMID: 12081828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose and insulin responses to dietary chromium supplements: a meta-analysis. AU - Althuis,Michelle D, AU - Jordan,Nicole E, AU - Ludington,Elizabeth A, AU - Wittes,Janet T, PY - 2002/6/26/pubmed PY - 2002/7/18/medline PY - 2002/6/26/entrez SP - 148 EP - 55 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 76 IS - 1 N2 - BACKGROUND: Several authors, mostly on the basis of nonrandomized studies, have suggested dietary trivalent chromium supplementation as an attractive option for the management of type 2 diabetes and for glycemic control in persons at high risk of type 2 diabetes. OBJECTIVE: The study aimed to determine the effect of chromium on glucose and insulin responses in healthy subjects and in individuals with glucose intolerance or type 2 diabetes. DESIGN: The study design was a systematic review and meta-analysis of randomized clinical trials (RCTs). RESULTS: The authors identified 20 reports of RCTs assessing the effect of chromium on glucose, insulin, or glycated hemoglobin (Hb A(1c)). This review summarizes data on 618 participants from the 15 trials that reported adequate data: 193 participants had type 2 diabetes and 425 were in good health or had impaired glucose tolerance. The meta-analysis showed no association between chromium and glucose or insulin concentrations among nondiabetic subjects. A study of 155 diabetic subjects in China showed that chromium reduced glucose and insulin concentrations; the combined data from the 38 diabetic subjects in the other studies did not. Three trials reported data on Hb A(1c): one study each of persons with type 2 diabetes, persons with impaired glucose tolerance, and healthy subjects. The study of diabetic subjects in China was the only one to report that chromium significantly reduced Hb A(1c). CONCLUSIONS: Data from RCTs show no effect of chromium on glucose or insulin concentrations in nondiabetic subjects. The data for persons with diabetes are inconclusive. RCTs in well-characterized, at-risk populations are necessary to determine the effects of chromium on glucose, insulin, and Hb A(1c). SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12081828/Glucose_and_insulin_responses_to_dietary_chromium_supplements:_a_meta_analysis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.1.148 DB - PRIME DP - Unbound Medicine ER -