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Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake.
Am J Clin Nutr. 2002 Jul; 76(1):172-9.AJ

Abstract

BACKGROUND

Plasma and adipose tissue concentrations of carotenoids are thought to reflect short- and long-term intakes of carotenoids, respectively. The ability of adipose tissue carotenoid concentrations to reflect dietary intake in population studies is unknown.

OBJECTIVE

We examined the relation between intakes of the major dietary carotenoids and their concentrations in plasma and adipose tissue.

DESIGN

A blood sample and an adipose tissue biopsy sample were collected from 115 women and 344 men in Costa Rica after they had fasted overnight, and a dietary interview based on a 135-item food-frequency questionnaire was administered. After carotenoid intake was adjusted for total energy intake and plasma concentrations were adjusted for HDL-, LDL-, and VLDL-cholesterol concentrations, we calculated partial Spearman correlation coefficients that were adjusted for age, sex, smoking, and body mass index.

RESULTS

In women, the correlations (r) between intakes and concentrations of alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein+zeaxanthin were 0.25, 0.29, 0.44, and 0.17, respectively (P < 0.05 for r > or = 0.19), in adipose tissue and 0.26, 0.13, 0.55, and 0.22 in plasma. In men, these values were 0.04, 0.07, 0.23, and 0.06 in adipose tissue and 0.24, 0.22, 0.44, and 0.20 in plasma. In women and men, correlations for lycopene were higher in plasma (r = 0.19 and 0.35, respectively) than in adipose tissue (r = 0.14 and 0.26). The relative abundance of each carotenoid in the diet was similar to its distribution in plasma but not in adipose tissue.

CONCLUSION

The usefulness of adipose tissue and plasma carotenoids as biomarkers of intake is similar, although correlations for individual carotenoids vary substantially.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12081831

Citation

El-Sohemy, Ahmed, et al. "Individual Carotenoid Concentrations in Adipose Tissue and Plasma as Biomarkers of Dietary Intake." The American Journal of Clinical Nutrition, vol. 76, no. 1, 2002, pp. 172-9.
El-Sohemy A, Baylin A, Kabagambe E, et al. Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. Am J Clin Nutr. 2002;76(1):172-9.
El-Sohemy, A., Baylin, A., Kabagambe, E., Ascherio, A., Spiegelman, D., & Campos, H. (2002). Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. The American Journal of Clinical Nutrition, 76(1), 172-9.
El-Sohemy A, et al. Individual Carotenoid Concentrations in Adipose Tissue and Plasma as Biomarkers of Dietary Intake. Am J Clin Nutr. 2002;76(1):172-9. PubMed PMID: 12081831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. AU - El-Sohemy,Ahmed, AU - Baylin,Ana, AU - Kabagambe,Edmond, AU - Ascherio,Alberto, AU - Spiegelman,Donna, AU - Campos,Hannia, PY - 2002/6/26/pubmed PY - 2002/7/18/medline PY - 2002/6/26/entrez SP - 172 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 76 IS - 1 N2 - BACKGROUND: Plasma and adipose tissue concentrations of carotenoids are thought to reflect short- and long-term intakes of carotenoids, respectively. The ability of adipose tissue carotenoid concentrations to reflect dietary intake in population studies is unknown. OBJECTIVE: We examined the relation between intakes of the major dietary carotenoids and their concentrations in plasma and adipose tissue. DESIGN: A blood sample and an adipose tissue biopsy sample were collected from 115 women and 344 men in Costa Rica after they had fasted overnight, and a dietary interview based on a 135-item food-frequency questionnaire was administered. After carotenoid intake was adjusted for total energy intake and plasma concentrations were adjusted for HDL-, LDL-, and VLDL-cholesterol concentrations, we calculated partial Spearman correlation coefficients that were adjusted for age, sex, smoking, and body mass index. RESULTS: In women, the correlations (r) between intakes and concentrations of alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein+zeaxanthin were 0.25, 0.29, 0.44, and 0.17, respectively (P < 0.05 for r > or = 0.19), in adipose tissue and 0.26, 0.13, 0.55, and 0.22 in plasma. In men, these values were 0.04, 0.07, 0.23, and 0.06 in adipose tissue and 0.24, 0.22, 0.44, and 0.20 in plasma. In women and men, correlations for lycopene were higher in plasma (r = 0.19 and 0.35, respectively) than in adipose tissue (r = 0.14 and 0.26). The relative abundance of each carotenoid in the diet was similar to its distribution in plasma but not in adipose tissue. CONCLUSION: The usefulness of adipose tissue and plasma carotenoids as biomarkers of intake is similar, although correlations for individual carotenoids vary substantially. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12081831/Individual_carotenoid_concentrations_in_adipose_tissue_and_plasma_as_biomarkers_of_dietary_intake_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.1.172 DB - PRIME DP - Unbound Medicine ER -