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Antioxidant activity of extracts from Euryale ferox seed.
Exp Mol Med. 2002 May 31; 34(2):100-6.EM

Abstract

Euryale ferox has been widely used in traditional oriental medicine to treat a variety of illness. However, very little is known about the cellular actions by which this plant mediates its therapeutic effects. Various aspects of antioxidant activity were evaluated in total extracts and fractions derived from Euryale ferox. Total extracts (IC50 5.6 microg/ml) showed relatively high level radical scavenging activity toward 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and also enhanced viability of Chinese hamster lung fibroblast (V79-4) cells under exposure to oxidative agents. Upon further fractionation, the highest levels of DPPH radical scavenging and lipid peroxidation inhibitory activities were found in the ethyl acetate and butanol fractions. The ethyl acetate fractions, the butanol fractions, and total extracts of Euryale ferox also dose-dependently enhanced the activities of superoxide dismutase, catalase and glutathione peroxidase in V79-4 cells. Of these three antioxidant enzymes, glutathione peroxidase activity was most strongly induced. Taken together, our findings show that Euryale ferox contains a significant antioxidant activity and that specific components in the ethyl acetate and butanol fractions may play an important role in mediating these antioxidant properties.

Authors+Show Affiliations

Department of Oral Biochemistry, College of Dentistry, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12085984

Citation

Lee, Si Eun, et al. "Antioxidant Activity of Extracts From Euryale Ferox Seed." Experimental & Molecular Medicine, vol. 34, no. 2, 2002, pp. 100-6.
Lee SE, Ju EM, Kim JH. Antioxidant activity of extracts from Euryale ferox seed. Exp Mol Med. 2002;34(2):100-6.
Lee, S. E., Ju, E. M., & Kim, J. H. (2002). Antioxidant activity of extracts from Euryale ferox seed. Experimental & Molecular Medicine, 34(2), 100-6.
Lee SE, Ju EM, Kim JH. Antioxidant Activity of Extracts From Euryale Ferox Seed. Exp Mol Med. 2002 May 31;34(2):100-6. PubMed PMID: 12085984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of extracts from Euryale ferox seed. AU - Lee,Si Eun, AU - Ju,Eun Mi, AU - Kim,Jeong Hee, PY - 2002/6/28/pubmed PY - 2003/7/31/medline PY - 2002/6/28/entrez SP - 100 EP - 6 JF - Experimental & molecular medicine JO - Exp Mol Med VL - 34 IS - 2 N2 - Euryale ferox has been widely used in traditional oriental medicine to treat a variety of illness. However, very little is known about the cellular actions by which this plant mediates its therapeutic effects. Various aspects of antioxidant activity were evaluated in total extracts and fractions derived from Euryale ferox. Total extracts (IC50 5.6 microg/ml) showed relatively high level radical scavenging activity toward 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and also enhanced viability of Chinese hamster lung fibroblast (V79-4) cells under exposure to oxidative agents. Upon further fractionation, the highest levels of DPPH radical scavenging and lipid peroxidation inhibitory activities were found in the ethyl acetate and butanol fractions. The ethyl acetate fractions, the butanol fractions, and total extracts of Euryale ferox also dose-dependently enhanced the activities of superoxide dismutase, catalase and glutathione peroxidase in V79-4 cells. Of these three antioxidant enzymes, glutathione peroxidase activity was most strongly induced. Taken together, our findings show that Euryale ferox contains a significant antioxidant activity and that specific components in the ethyl acetate and butanol fractions may play an important role in mediating these antioxidant properties. SN - 1226-3613 UR - https://www.unboundmedicine.com/medline/citation/12085984/Antioxidant_activity_of_extracts_from_Euryale_ferox_seed_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -