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A prospective study of obesity and risk of coronary heart disease among diabetic women.
Diabetes Care 2002; 25(7):1142-8DC

Abstract

OBJECTIVE

To examine the relationship of obesity, measured as BMI, and weight change to incidence of coronary heart disease (CHD) among women with diabetes.

RESEARCH DESIGN AND METHODS

We followed 5,897 women with type 2 diabetes in the Nurses' Health Study for < or = 20 years. Women were aged 40-74 years and had no history of cardiovascular disease or cancer at the beginning of the follow-up period. BMI values from three time points (age 18 years, year 1976, and current) were derived from the reported height (1976) and corresponding reported weight. Weight changes between age 18 years and 1976 and after diagnosis of diabetes were calculated. Women reported diagnoses of diabetes and CHD every 2 years. Incident CHD cases were confirmed by medical record review.

RESULTS

During follow-up, we documented 418 incident cases of CHD (236 of nonfatal myocardial infarction and 182 of fatal CHD). After adjustment for age, smoking, and other coronary risk factors, current BMI was strongly associated with increased risk of CHD among diabetic women. The multivariate relative risks across increasing categories of BMI (<23.0, 23.0-24.9, 25.0-26.9, 27.0-29.9, 30.0-34.9, and > or = 35.0 kg/m(2)) were 1.0, 1.58, 1.85, 1.95, 2.80, and 3.21, respectively (P for trend <0.001). Increasing BMI values from age 18 years to 1976, before diagnosis of diabetes, were also positively associated with risk of CHD. Weight gain before the diagnosis of diabetes was related to increased risk of CHD. In contrast, weight change after diagnosis of diabetes was not associated with risk of CHD.

CONCLUSIONS

These findings provide strong evidence that obesity and weight gain before diagnosis of diabetes are associated with future risk of CHD among women with type 2 diabetes.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. eunyoung.cho@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12087011

Citation

Cho, Eunyoung, et al. "A Prospective Study of Obesity and Risk of Coronary Heart Disease Among Diabetic Women." Diabetes Care, vol. 25, no. 7, 2002, pp. 1142-8.
Cho E, Manson JE, Stampfer MJ, et al. A prospective study of obesity and risk of coronary heart disease among diabetic women. Diabetes Care. 2002;25(7):1142-8.
Cho, E., Manson, J. E., Stampfer, M. J., Solomon, C. G., Colditz, G. A., Speizer, F. E., ... Hu, F. B. (2002). A prospective study of obesity and risk of coronary heart disease among diabetic women. Diabetes Care, 25(7), pp. 1142-8.
Cho E, et al. A Prospective Study of Obesity and Risk of Coronary Heart Disease Among Diabetic Women. Diabetes Care. 2002;25(7):1142-8. PubMed PMID: 12087011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of obesity and risk of coronary heart disease among diabetic women. AU - Cho,Eunyoung, AU - Manson,JoAnn E, AU - Stampfer,Meir J, AU - Solomon,Caren G, AU - Colditz,Graham A, AU - Speizer,Frank E, AU - Willett,Walter C, AU - Hu,Frank B, PY - 2002/6/28/pubmed PY - 2002/12/17/medline PY - 2002/6/28/entrez SP - 1142 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 25 IS - 7 N2 - OBJECTIVE: To examine the relationship of obesity, measured as BMI, and weight change to incidence of coronary heart disease (CHD) among women with diabetes. RESEARCH DESIGN AND METHODS: We followed 5,897 women with type 2 diabetes in the Nurses' Health Study for < or = 20 years. Women were aged 40-74 years and had no history of cardiovascular disease or cancer at the beginning of the follow-up period. BMI values from three time points (age 18 years, year 1976, and current) were derived from the reported height (1976) and corresponding reported weight. Weight changes between age 18 years and 1976 and after diagnosis of diabetes were calculated. Women reported diagnoses of diabetes and CHD every 2 years. Incident CHD cases were confirmed by medical record review. RESULTS: During follow-up, we documented 418 incident cases of CHD (236 of nonfatal myocardial infarction and 182 of fatal CHD). After adjustment for age, smoking, and other coronary risk factors, current BMI was strongly associated with increased risk of CHD among diabetic women. The multivariate relative risks across increasing categories of BMI (<23.0, 23.0-24.9, 25.0-26.9, 27.0-29.9, 30.0-34.9, and > or = 35.0 kg/m(2)) were 1.0, 1.58, 1.85, 1.95, 2.80, and 3.21, respectively (P for trend <0.001). Increasing BMI values from age 18 years to 1976, before diagnosis of diabetes, were also positively associated with risk of CHD. Weight gain before the diagnosis of diabetes was related to increased risk of CHD. In contrast, weight change after diagnosis of diabetes was not associated with risk of CHD. CONCLUSIONS: These findings provide strong evidence that obesity and weight gain before diagnosis of diabetes are associated with future risk of CHD among women with type 2 diabetes. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/12087011/A_prospective_study_of_obesity_and_risk_of_coronary_heart_disease_among_diabetic_women_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=12087011 DB - PRIME DP - Unbound Medicine ER -