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Oral contraceptives and the risk of breast cancer.
N Engl J Med 2002; 346(26):2025-32NEJM

Abstract

BACKGROUND

It is uncertain whether the use of an oral contraceptive increases the risk of breast cancer later in life, when the incidence of breast cancer is increased. We conducted a population-based, case-control study to determine the risk of breast cancer among former and current users of oral contraceptives.

METHODS

We interviewed women who were 35 to 64 years old. A total of 4575 women with breast cancer and 4682 controls were interviewed. Conditional logistic regression was used to calculate odds ratios as estimates of the relative risk (incidence-density ratios) of breast cancer.

RESULTS

The relative risk was 1.0 (95 percent confidence interval, 0.8 to 1.3) for women who were currently using oral contraceptives and 0.9 (95 percent confidence interval, 0.8 to 1.0) for those who had previously used them. The relative risk did not increase consistently with longer periods of use or with higher doses of estrogen. The results were similar among white and black women. Use of oral contraceptives by women with a family history of breast cancer was not associated with an increased risk of breast cancer, nor was the initiation of oral-contraceptive use at a young age.

CONCLUSIONS

Among women from 35 to 64 years of age, current or former oral-contraceptive use was not associated with a significantly increased risk of breast cancer.

Authors+Show Affiliations

Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12087137

Citation

Marchbanks, Polly A., et al. "Oral Contraceptives and the Risk of Breast Cancer." The New England Journal of Medicine, vol. 346, no. 26, 2002, pp. 2025-32.
Marchbanks PA, McDonald JA, Wilson HG, et al. Oral contraceptives and the risk of breast cancer. N Engl J Med. 2002;346(26):2025-32.
Marchbanks, P. A., McDonald, J. A., Wilson, H. G., Folger, S. G., Mandel, M. G., Daling, J. R., ... Weiss, L. K. (2002). Oral contraceptives and the risk of breast cancer. The New England Journal of Medicine, 346(26), pp. 2025-32.
Marchbanks PA, et al. Oral Contraceptives and the Risk of Breast Cancer. N Engl J Med. 2002 Jun 27;346(26):2025-32. PubMed PMID: 12087137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptives and the risk of breast cancer. AU - Marchbanks,Polly A, AU - McDonald,Jill A, AU - Wilson,Hoyt G, AU - Folger,Suzanne G, AU - Mandel,Michele G, AU - Daling,Janet R, AU - Bernstein,Leslie, AU - Malone,Kathleen E, AU - Ursin,Giske, AU - Strom,Brian L, AU - Norman,Sandra A, AU - Wingo,Phyllis A, AU - Burkman,Ronald T, AU - Berlin,Jesse A, AU - Simon,Michael S, AU - Spirtas,Robert, AU - Weiss,Linda K, PY - 2002/6/28/pubmed PY - 2002/7/3/medline PY - 2002/6/28/entrez SP - 2025 EP - 32 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 346 IS - 26 N2 - BACKGROUND: It is uncertain whether the use of an oral contraceptive increases the risk of breast cancer later in life, when the incidence of breast cancer is increased. We conducted a population-based, case-control study to determine the risk of breast cancer among former and current users of oral contraceptives. METHODS: We interviewed women who were 35 to 64 years old. A total of 4575 women with breast cancer and 4682 controls were interviewed. Conditional logistic regression was used to calculate odds ratios as estimates of the relative risk (incidence-density ratios) of breast cancer. RESULTS: The relative risk was 1.0 (95 percent confidence interval, 0.8 to 1.3) for women who were currently using oral contraceptives and 0.9 (95 percent confidence interval, 0.8 to 1.0) for those who had previously used them. The relative risk did not increase consistently with longer periods of use or with higher doses of estrogen. The results were similar among white and black women. Use of oral contraceptives by women with a family history of breast cancer was not associated with an increased risk of breast cancer, nor was the initiation of oral-contraceptive use at a young age. CONCLUSIONS: Among women from 35 to 64 years of age, current or former oral-contraceptive use was not associated with a significantly increased risk of breast cancer. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/12087137/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJMoa013202?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -