Tags

Type your tag names separated by a space and hit enter

Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children.
Clin Infect Dis 2002; 35(2):168-74CI

Abstract

To evaluate the efficacy of an intranasal, inactivated, virosomal subunit influenza vaccine for prevention of new episodes of acute otitis media (AOM) in children with recurrent AOM, 133 children aged 1-5 years were randomized to receive the vaccine (n=67) or no vaccination (n=66). During a 6-month period, 24 (35.8%) vaccine recipients had 32 episodes of AOM; 42 (63.6%) control subjects had 64 episodes. The overall efficacy of vaccination in preventing AOM was 43.7% (95% confidence interval, 18.6-61.1; P=.002). Children vaccinated before influenza season had a significantly better outcome than did those vaccinated after the onset of influenza season. The cumulative duration of middle ear effusion was significantly less in vaccinated children than in control subjects. Data suggest that the intranasal virosomal influenza vaccine might be considered among the options for the prevention of AOM in children <5 years old with recurrent AOM.

Authors+Show Affiliations

Pediatric Department 1, University of Milan, 20122 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12087523

Citation

Marchisio, Paola, et al. "Efficacy of Intranasal Virosomal Influenza Vaccine in the Prevention of Recurrent Acute Otitis Media in Children." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 35, no. 2, 2002, pp. 168-74.
Marchisio P, Cavagna R, Maspes B, et al. Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children. Clin Infect Dis. 2002;35(2):168-74.
Marchisio, P., Cavagna, R., Maspes, B., Gironi, S., Esposito, S., Lambertini, L., ... Principi, N. (2002). Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 35(2), pp. 168-74.
Marchisio P, et al. Efficacy of Intranasal Virosomal Influenza Vaccine in the Prevention of Recurrent Acute Otitis Media in Children. Clin Infect Dis. 2002 Jul 15;35(2):168-74. PubMed PMID: 12087523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children. AU - Marchisio,Paola, AU - Cavagna,Roberta, AU - Maspes,Barbara, AU - Gironi,Stefania, AU - Esposito,Susanna, AU - Lambertini,Lara, AU - Massimini,Alessandra, AU - Herzog,Christian, AU - Principi,Nicola, Y1 - 2002/06/19/ PY - 2001/12/17/received PY - 2002/02/25/revised PY - 2002/6/28/pubmed PY - 2002/8/6/medline PY - 2002/6/28/entrez SP - 168 EP - 74 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 35 IS - 2 N2 - To evaluate the efficacy of an intranasal, inactivated, virosomal subunit influenza vaccine for prevention of new episodes of acute otitis media (AOM) in children with recurrent AOM, 133 children aged 1-5 years were randomized to receive the vaccine (n=67) or no vaccination (n=66). During a 6-month period, 24 (35.8%) vaccine recipients had 32 episodes of AOM; 42 (63.6%) control subjects had 64 episodes. The overall efficacy of vaccination in preventing AOM was 43.7% (95% confidence interval, 18.6-61.1; P=.002). Children vaccinated before influenza season had a significantly better outcome than did those vaccinated after the onset of influenza season. The cumulative duration of middle ear effusion was significantly less in vaccinated children than in control subjects. Data suggest that the intranasal virosomal influenza vaccine might be considered among the options for the prevention of AOM in children <5 years old with recurrent AOM. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/12087523/Efficacy_of_intranasal_virosomal_influenza_vaccine_in_the_prevention_of_recurrent_acute_otitis_media_in_children_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/341028 DB - PRIME DP - Unbound Medicine ER -