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A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat.
Psychopharmacologia. 1975 Nov 21; 44(3):225-8.P

Abstract

The effects of 0.75 mg/kg of R-DOM and 1.0 mg/kg of S-amphetamine served as discriminative stimuli in the control of a two-lever discrimination response. Dose-response evaluation of the two agents indicated that in S-amphetamine-trained animals the drug effects produced by test doses of 0.5 to 2.2 mg/kg of S-amphetamine could be considered as a dose-dependent continuum of low to high stimulus intensity. In R-DOM trained subjects, low to moderate doses of R-DOM (0.5-1.5 mg/kg) produced dose-related discriminative responding, but the high dose of R-DOM (2.2 mg/kg) resulted in random responding. When animals trained to discriminate 1.0 mg/kg of S-amphetamine from saline were given 0.5 or 0.75 mg/kg of R-DOM, they tended to respond on the drug correct lever. However, higher doses of R-DOM (1.5 and 2.2 mg/kg) produced random responding. Similarly, animals trained to discriminate 0.75 mg/kg of R-DOM from saline exhibited correct responses following 0.5 and 0.75 mg/kg of S-amphetamine, but not after 1.5 and 2.2 mg/kg. These data suggest that low doses of R-DOM produce discriminative stimuli that are qualitatively different from those of higher doses. Stimuli following low doses of R-DOM also appear similar in some respects to those following low doses of S-amphetamine.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1208758

Citation

Tilson, H A., et al. "A Comparison of the Discriminative Stimulus Properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the Rat." Psychopharmacologia, vol. 44, no. 3, 1975, pp. 225-8.
Tilson HA, Baker TG, Gylys JA. A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat. Psychopharmacologia. 1975;44(3):225-8.
Tilson, H. A., Baker, T. G., & Gylys, J. A. (1975). A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat. Psychopharmacologia, 44(3), 225-8.
Tilson HA, Baker TG, Gylys JA. A Comparison of the Discriminative Stimulus Properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the Rat. Psychopharmacologia. 1975 Nov 21;44(3):225-8. PubMed PMID: 1208758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat. AU - Tilson,H A, AU - Baker,T G, AU - Gylys,J A, PY - 1975/11/21/pubmed PY - 1975/11/21/medline PY - 1975/11/21/entrez SP - 225 EP - 8 JF - Psychopharmacologia JO - Psychopharmacologia VL - 44 IS - 3 N2 - The effects of 0.75 mg/kg of R-DOM and 1.0 mg/kg of S-amphetamine served as discriminative stimuli in the control of a two-lever discrimination response. Dose-response evaluation of the two agents indicated that in S-amphetamine-trained animals the drug effects produced by test doses of 0.5 to 2.2 mg/kg of S-amphetamine could be considered as a dose-dependent continuum of low to high stimulus intensity. In R-DOM trained subjects, low to moderate doses of R-DOM (0.5-1.5 mg/kg) produced dose-related discriminative responding, but the high dose of R-DOM (2.2 mg/kg) resulted in random responding. When animals trained to discriminate 1.0 mg/kg of S-amphetamine from saline were given 0.5 or 0.75 mg/kg of R-DOM, they tended to respond on the drug correct lever. However, higher doses of R-DOM (1.5 and 2.2 mg/kg) produced random responding. Similarly, animals trained to discriminate 0.75 mg/kg of R-DOM from saline exhibited correct responses following 0.5 and 0.75 mg/kg of S-amphetamine, but not after 1.5 and 2.2 mg/kg. These data suggest that low doses of R-DOM produce discriminative stimuli that are qualitatively different from those of higher doses. Stimuli following low doses of R-DOM also appear similar in some respects to those following low doses of S-amphetamine. UR - https://www.unboundmedicine.com/medline/citation/1208758/A_comparison_of_the_discriminative_stimulus_properties_of_R_25_dimethoxy_4_methylamphetamine__R_DOM__and_S_amphetamine_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -