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Younger age at vaccination may increase risk of varicella vaccine failure.
J Infect Dis. 2002 Jul 01; 186(1):102-5.JI

Abstract

To determine vaccine effectiveness (VE), a varicella outbreak in a highly vaccinated day-care center (DCC) population in Pennsylvania was investigated. In Pennsylvania, proof of immunity is required for children >or=12 months old for DCC enrollment. Questionnaires were administered to parents of children who had attended the DCC continuously during the study period (1 November 1999-9 April 2000) to determine history of varicella disease or vaccination and for information about any recent rash illnesses. VE was calculated for children >or=12 months old without a history of varicella. There were 41 cases of varicella among 131 attendees, with 14 cases (34%) among vaccinated children. VE was 79% against all varicella and 95% against moderate or severe varicella. Vaccination at <14 months was associated with an increased risk of breakthrough disease (relative risk, 3.0; 95% confidence interval, 0.9-9.9). Despite varicella vaccination coverage of 80%, a sizeable outbreak occurred. Early age at vaccination may increase the risk of vaccine failure.

Authors+Show Affiliations

Galil K
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. kgalil@cdc.gov
Fair E
No affiliation info available
Mountcastle N
No affiliation info available
Britz P
No affiliation info available
Seward J
No affiliation info available

MeSH

Age FactorsChickenpoxChickenpox VaccineChildChild Day Care CentersChild, PreschoolDisease OutbreaksFemaleHumansInfantMaleRisk FactorsSurveys and QuestionnairesUnited StatesVaccination

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12089668

Citation

Galil, Karin, et al. "Younger Age at Vaccination May Increase Risk of Varicella Vaccine Failure." The Journal of Infectious Diseases, vol. 186, no. 1, 2002, pp. 102-5.
Galil K, Fair E, Mountcastle N, et al. Younger age at vaccination may increase risk of varicella vaccine failure. J Infect Dis. 2002;186(1):102-5.
Galil, K., Fair, E., Mountcastle, N., Britz, P., & Seward, J. (2002). Younger age at vaccination may increase risk of varicella vaccine failure. The Journal of Infectious Diseases, 186(1), 102-5.
Galil K, et al. Younger Age at Vaccination May Increase Risk of Varicella Vaccine Failure. J Infect Dis. 2002 Jul 1;186(1):102-5. PubMed PMID: 12089668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Younger age at vaccination may increase risk of varicella vaccine failure. AU - Galil,Karin, AU - Fair,Elizabeth, AU - Mountcastle,Norine, AU - Britz,Phyllis, AU - Seward,Jane, Y1 - 2002/06/05/ PY - 2002/01/08/received PY - 2002/02/28/revised PY - 2002/6/29/pubmed PY - 2002/8/2/medline PY - 2002/6/29/entrez SP - 102 EP - 5 JF - The Journal of infectious diseases JO - J Infect Dis VL - 186 IS - 1 N2 - To determine vaccine effectiveness (VE), a varicella outbreak in a highly vaccinated day-care center (DCC) population in Pennsylvania was investigated. In Pennsylvania, proof of immunity is required for children >or=12 months old for DCC enrollment. Questionnaires were administered to parents of children who had attended the DCC continuously during the study period (1 November 1999-9 April 2000) to determine history of varicella disease or vaccination and for information about any recent rash illnesses. VE was calculated for children >or=12 months old without a history of varicella. There were 41 cases of varicella among 131 attendees, with 14 cases (34%) among vaccinated children. VE was 79% against all varicella and 95% against moderate or severe varicella. Vaccination at <14 months was associated with an increased risk of breakthrough disease (relative risk, 3.0; 95% confidence interval, 0.9-9.9). Despite varicella vaccination coverage of 80%, a sizeable outbreak occurred. Early age at vaccination may increase the risk of vaccine failure. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12089668/Younger_age_at_vaccination_may_increase_risk_of_varicella_vaccine_failure_ DB - PRIME DP - Unbound Medicine ER -