Tags

Type your tag names separated by a space and hit enter

The impact of an enteroviral RT-PCR assay on the diagnosis of aseptic meningitis and patient management.
J Clin Virol. 2002 Jul; 25 Suppl 1:S19-26.JC

Abstract

BACKGROUND

Enterovirus (EV) is a major cause of aseptic meningitis and non-specific febrile illness in children. Since the majority of patients are hospitalized for possible bacterial infection, a rapid test for the diagnosis of enteroviral meningitis (EVM) may reduce hospitalizations and unnecessary treatments.

OBJECTIVE

To review the impact of an EV reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the diagnosis of EVM on patient management.

STUDY DESIGN

CSF from 1056 patients admitted to the hospital between 1998 and 2001 was tested using EV RT-PCR. The results were correlated with CSF counts, diagnosis, test turnaround time (TAT) and length of hospital stay (LOS).

RESULTS

EV RT-PCR was positive for 113 patients (11%). Of these cases, 92% occurred during the summer months and 77% were in children <19 years of age. Children <3 years old with EVM frequently had non-specific clinical findings and lacked pleocytosis. There was a significant correlation between decreasing LOS and TAT (r(2)=0.97, P<0.001).

CONCLUSION

RT-PCR testing for EVM is an important tool to aid in the diagnosis of children with non-specific febrile illness. This test impacted patient management as measured by shortened patient stays, which should translate into significant health care savings.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. stellrk@mail.amc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12091078

Citation

Stellrecht, K A., et al. "The Impact of an Enteroviral RT-PCR Assay On the Diagnosis of Aseptic Meningitis and Patient Management." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 25 Suppl 1, 2002, pp. S19-26.
Stellrecht KA, Harding I, Woron AM, et al. The impact of an enteroviral RT-PCR assay on the diagnosis of aseptic meningitis and patient management. J Clin Virol. 2002;25 Suppl 1:S19-26.
Stellrecht, K. A., Harding, I., Woron, A. M., Lepow, M. L., & Venezia, R. A. (2002). The impact of an enteroviral RT-PCR assay on the diagnosis of aseptic meningitis and patient management. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 25 Suppl 1, S19-26.
Stellrecht KA, et al. The Impact of an Enteroviral RT-PCR Assay On the Diagnosis of Aseptic Meningitis and Patient Management. J Clin Virol. 2002;25 Suppl 1:S19-26. PubMed PMID: 12091078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of an enteroviral RT-PCR assay on the diagnosis of aseptic meningitis and patient management. AU - Stellrecht,K A, AU - Harding,I, AU - Woron,A M, AU - Lepow,M L, AU - Venezia,R A, PY - 2002/7/2/pubmed PY - 2003/2/14/medline PY - 2002/7/2/entrez SP - S19 EP - 26 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 25 Suppl 1 N2 - BACKGROUND: Enterovirus (EV) is a major cause of aseptic meningitis and non-specific febrile illness in children. Since the majority of patients are hospitalized for possible bacterial infection, a rapid test for the diagnosis of enteroviral meningitis (EVM) may reduce hospitalizations and unnecessary treatments. OBJECTIVE: To review the impact of an EV reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the diagnosis of EVM on patient management. STUDY DESIGN: CSF from 1056 patients admitted to the hospital between 1998 and 2001 was tested using EV RT-PCR. The results were correlated with CSF counts, diagnosis, test turnaround time (TAT) and length of hospital stay (LOS). RESULTS: EV RT-PCR was positive for 113 patients (11%). Of these cases, 92% occurred during the summer months and 77% were in children <19 years of age. Children <3 years old with EVM frequently had non-specific clinical findings and lacked pleocytosis. There was a significant correlation between decreasing LOS and TAT (r(2)=0.97, P<0.001). CONCLUSION: RT-PCR testing for EVM is an important tool to aid in the diagnosis of children with non-specific febrile illness. This test impacted patient management as measured by shortened patient stays, which should translate into significant health care savings. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/12091078/The_impact_of_an_enteroviral_RT_PCR_assay_on_the_diagnosis_of_aseptic_meningitis_and_patient_management_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386653202000306 DB - PRIME DP - Unbound Medicine ER -