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Perinatal outcome in large-for-gestational-age infants. Is it influenced by gestational impaired glucose tolerance?
J Reprod Med. 2002 Jun; 47(6):497-502.JR

Abstract

OBJECTIVE

To examine the relationship between the World Health Organization category of impaired glucose tolerance (IGT) (two-hour value of the 75-g oral glucose tolerance test at 8-10.9 mmol/L) and outcome in large-for-gestational age (LGA) infants to determine whether IGT affects perinatal morbidity in addition to affecting infant size.

STUDY DESIGN

A retrospective study was performed on 461 LGA newborns (birth weight > 90th percentile) from singleton pregnancies delivering after 36 completed weeks in a 12-month period to determine the difference in perinatal outcome between nondiabetic pregnancies (n = 382) and pregnancies with diet-treated IGT (n = 79).

RESULTS

The IGT group had significantly higher mean maternal age, prepregnancy weight and body mass index (BMI) but lower absolute and percent gestational weight gain and no difference in infant gestational age, birth weight, BMI, incidence of macrosomia (birth weight > or = 4,000 g) or obstetric complications. However, the IGT group had an increased incidence of Erb's palsy (OR 7.81, 95% CI 1.76-34.62), meconium aspiration syndrome (OR 5.29, 95% CI 1.27-22.02), phototherapy (OR 2.10, 95% CI 1.03-5.69), sepsis (OR 2.90, 95% CI 1.25-6.74) and shoulder dystocia (OR 5.64, 95% CI 1.06-29.89) after adjusting for confounding factors (maternal age and BMI, postdate pregnancy, mode of delivery and infant sex).

CONCLUSION

Despite dietary treatment, maternal IGT is associated with increased perinatal morbidity independent of its effect on fetal size.

Authors+Show Affiliations

Lao TT
Department of Obstetrics and Gynaecology, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, P.R.C. laotth@hkucc.hku.hk
Wong KY
No affiliation info available

MeSH

AdultBirth WeightBody Mass IndexBody WeightConfounding Factors, EpidemiologicDiabetes, GestationalFemaleFetal MacrosomiaGestational AgeGlucose IntoleranceGlucose Tolerance TestHumansIncidenceInfant, NewbornMass ScreeningMaternal AgePregnancyPregnancy OutcomePrenatal CareRetrospective StudiesRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12092021

Citation

Lao, Terence T., and Kar-Yin Wong. "Perinatal Outcome in Large-for-gestational-age Infants. Is It Influenced By Gestational Impaired Glucose Tolerance?" The Journal of Reproductive Medicine, vol. 47, no. 6, 2002, pp. 497-502.
Lao TT, Wong KY. Perinatal outcome in large-for-gestational-age infants. Is it influenced by gestational impaired glucose tolerance? J Reprod Med. 2002;47(6):497-502.
Lao, T. T., & Wong, K. Y. (2002). Perinatal outcome in large-for-gestational-age infants. Is it influenced by gestational impaired glucose tolerance? The Journal of Reproductive Medicine, 47(6), 497-502.
Lao TT, Wong KY. Perinatal Outcome in Large-for-gestational-age Infants. Is It Influenced By Gestational Impaired Glucose Tolerance. J Reprod Med. 2002;47(6):497-502. PubMed PMID: 12092021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal outcome in large-for-gestational-age infants. Is it influenced by gestational impaired glucose tolerance? AU - Lao,Terence T, AU - Wong,Kar-Yin, PY - 2002/7/3/pubmed PY - 2002/12/21/medline PY - 2002/7/3/entrez SP - 497 EP - 502 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 47 IS - 6 N2 - OBJECTIVE: To examine the relationship between the World Health Organization category of impaired glucose tolerance (IGT) (two-hour value of the 75-g oral glucose tolerance test at 8-10.9 mmol/L) and outcome in large-for-gestational age (LGA) infants to determine whether IGT affects perinatal morbidity in addition to affecting infant size. STUDY DESIGN: A retrospective study was performed on 461 LGA newborns (birth weight > 90th percentile) from singleton pregnancies delivering after 36 completed weeks in a 12-month period to determine the difference in perinatal outcome between nondiabetic pregnancies (n = 382) and pregnancies with diet-treated IGT (n = 79). RESULTS: The IGT group had significantly higher mean maternal age, prepregnancy weight and body mass index (BMI) but lower absolute and percent gestational weight gain and no difference in infant gestational age, birth weight, BMI, incidence of macrosomia (birth weight > or = 4,000 g) or obstetric complications. However, the IGT group had an increased incidence of Erb's palsy (OR 7.81, 95% CI 1.76-34.62), meconium aspiration syndrome (OR 5.29, 95% CI 1.27-22.02), phototherapy (OR 2.10, 95% CI 1.03-5.69), sepsis (OR 2.90, 95% CI 1.25-6.74) and shoulder dystocia (OR 5.64, 95% CI 1.06-29.89) after adjusting for confounding factors (maternal age and BMI, postdate pregnancy, mode of delivery and infant sex). CONCLUSION: Despite dietary treatment, maternal IGT is associated with increased perinatal morbidity independent of its effect on fetal size. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/12092021/Perinatal_outcome_in_large_for_gestational_age_infants__Is_it_influenced_by_gestational_impaired_glucose_tolerance L2 - https://medlineplus.gov/birthweight.html DB - PRIME DP - Unbound Medicine ER -