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Exercise, diet, and childhood obesity: the GH-IGF-I connection.
J Pediatr Endocrinol Metab 2002; 15 Suppl 2:751-7JP

Abstract

The recent "obesity epidemic" among children and adolescents is a major public health concern. The mechanisms responsible for the increased incidence of childhood obesity are not yet well understood. The absence of a clear mechanism makes treating the obese child or adolescent a difficult task, and standardized therapeutic approaches simply do not yet exist. Metabolic derangements associated with obesity may contribute to the difficulty in treatment. Observed abnormalities in the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis in obese adults and the impact of exercise on the GH-IGF-I system are of particular relevance to the growing obese child. In this review, we focus on the interacting mechanisms of diet and exercise through specific hormonal mediators and their contribution to the current obesity epidemic. An improved understanding of these mechanisms may be helpful in creating effective treatment programs for children with obesity.

Authors+Show Affiliations

Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, College of Medicine, Orange 92868, USA. dcooper@uci.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12092690

Citation

Nemet, Dan, and Dan M. Cooper. "Exercise, Diet, and Childhood Obesity: the GH-IGF-I Connection." Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 15 Suppl 2, 2002, pp. 751-7.
Nemet D, Cooper DM. Exercise, diet, and childhood obesity: the GH-IGF-I connection. J Pediatr Endocrinol Metab. 2002;15 Suppl 2:751-7.
Nemet, D., & Cooper, D. M. (2002). Exercise, diet, and childhood obesity: the GH-IGF-I connection. Journal of Pediatric Endocrinology & Metabolism : JPEM, 15 Suppl 2, pp. 751-7.
Nemet D, Cooper DM. Exercise, Diet, and Childhood Obesity: the GH-IGF-I Connection. J Pediatr Endocrinol Metab. 2002;15 Suppl 2:751-7. PubMed PMID: 12092690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise, diet, and childhood obesity: the GH-IGF-I connection. AU - Nemet,Dan, AU - Cooper,Dan M, PY - 2002/7/3/pubmed PY - 2002/12/27/medline PY - 2002/7/3/entrez SP - 751 EP - 7 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. VL - 15 Suppl 2 N2 - The recent "obesity epidemic" among children and adolescents is a major public health concern. The mechanisms responsible for the increased incidence of childhood obesity are not yet well understood. The absence of a clear mechanism makes treating the obese child or adolescent a difficult task, and standardized therapeutic approaches simply do not yet exist. Metabolic derangements associated with obesity may contribute to the difficulty in treatment. Observed abnormalities in the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis in obese adults and the impact of exercise on the GH-IGF-I system are of particular relevance to the growing obese child. In this review, we focus on the interacting mechanisms of diet and exercise through specific hormonal mediators and their contribution to the current obesity epidemic. An improved understanding of these mechanisms may be helpful in creating effective treatment programs for children with obesity. SN - 0334-018X UR - https://www.unboundmedicine.com/medline/citation/12092690/Exercise_diet_and_childhood_obesity:_the_GH_IGF_I_connection_ L2 - https://www.degruyter.com/doi/10.1515/jpem.2002.15.s2.751 DB - PRIME DP - Unbound Medicine ER -