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Lorazepam for seizure prophylaxis during high-dose busulfan administration.
Bone Marrow Transplant. 2002 Jun; 29(12):963-5.BM

Abstract

Seizure is a recognized complication of high-dose busulfan (BU) therapy and phenytoin (DPH) is widely used as prophylaxis. A number of adverse effects have been associated with DPH and it may also interfere with BU metabolism. We used lorazepam (median dose 0.022 mg/kg) i.v. or p.o. before each dose and for 24 h after the last dose of BU as seizure prophylaxis to 29 children undergoing hematopoietic stem cell transplantation. The regimen was well tolerated and drowsiness was the only significant side-effect. Twelve patients were able to receive the entire prophylaxis by mouth. No seizure developed during and within 48 h of BU. Concomitant pharmacokinetic studies showed no alternation of the absorption and clearance of BU during lorazepam administration. Lorazepam can be used as an alternative for seizure prophylaxis during high-dose BU treatment.

Authors+Show Affiliations

Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12098063

Citation

Chan, K W., et al. "Lorazepam for Seizure Prophylaxis During High-dose Busulfan Administration." Bone Marrow Transplantation, vol. 29, no. 12, 2002, pp. 963-5.
Chan KW, Mullen CA, Worth LL, et al. Lorazepam for seizure prophylaxis during high-dose busulfan administration. Bone Marrow Transplant. 2002;29(12):963-5.
Chan, K. W., Mullen, C. A., Worth, L. L., Choroszy, M., Koontz, S., Tran, H., & Slopis, J. (2002). Lorazepam for seizure prophylaxis during high-dose busulfan administration. Bone Marrow Transplantation, 29(12), 963-5.
Chan KW, et al. Lorazepam for Seizure Prophylaxis During High-dose Busulfan Administration. Bone Marrow Transplant. 2002;29(12):963-5. PubMed PMID: 12098063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lorazepam for seizure prophylaxis during high-dose busulfan administration. AU - Chan,K W, AU - Mullen,C A, AU - Worth,L L, AU - Choroszy,M, AU - Koontz,S, AU - Tran,H, AU - Slopis,J, PY - 2002/01/31/received PY - 2002/03/19/accepted PY - 2002/7/5/pubmed PY - 2003/7/29/medline PY - 2002/7/5/entrez SP - 963 EP - 5 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 29 IS - 12 N2 - Seizure is a recognized complication of high-dose busulfan (BU) therapy and phenytoin (DPH) is widely used as prophylaxis. A number of adverse effects have been associated with DPH and it may also interfere with BU metabolism. We used lorazepam (median dose 0.022 mg/kg) i.v. or p.o. before each dose and for 24 h after the last dose of BU as seizure prophylaxis to 29 children undergoing hematopoietic stem cell transplantation. The regimen was well tolerated and drowsiness was the only significant side-effect. Twelve patients were able to receive the entire prophylaxis by mouth. No seizure developed during and within 48 h of BU. Concomitant pharmacokinetic studies showed no alternation of the absorption and clearance of BU during lorazepam administration. Lorazepam can be used as an alternative for seizure prophylaxis during high-dose BU treatment. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/12098063/Lorazepam_for_seizure_prophylaxis_during_high_dose_busulfan_administration_ L2 - https://doi.org/10.1038/sj.bmt.1703593 DB - PRIME DP - Unbound Medicine ER -