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Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion.
Eur J Pharmacol. 2002 Jun 20; 446(1-3):89-96.EJ

Abstract

The long-term behavioural and neurotoxic effects of 3,4-methlyenedioxymethampthetamine (MDMA, "Ecstasy") were examined in rats. Rats were given MDMA (5 mg/kg i.p. once per hour for 4 h) or vehicle injections on each of two consecutive days at an ambient temparature of 28 degrees C. MDMA caused acute hyperthermia and locomotor hyperactivity on both days. Four and six weeks after drug administration the rats previously treated with MDMA showed elevated levels of anxiety-like behaviour in the emergence and social interaction tests, respectively. At 9 weeks post-MDMA, the rats displayed an increase in anxiety on the elevated plus-maze test relative to controls. Ten weeks following treatment the rats were killed and their brains dissected and neurotramitter content analysed using High Performance Liquid Chromotography (HPLC). Rats previously given MDMA showed significantly decreased 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the amygdala, hippocampus and striatum relative to controls. This 5-HT depletion may have a causal role in producing increased anxiety-like behaviours in MDMA-treated rats. These results are consistent with human studies suggesting that exposure to high doses of MDMA may predispose to long-term psychological problems such as anxiety and depression.

Authors+Show Affiliations

Department of Psychology, University of Sydney, NSW 2006, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12098589

Citation

Gurtman, Clint G., et al. "Increased Anxiety in Rats After 3,4-methylenedioxymethamphetamine: Association With Serotonin Depletion." European Journal of Pharmacology, vol. 446, no. 1-3, 2002, pp. 89-96.
Gurtman CG, Morley KC, Li KM, et al. Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. Eur J Pharmacol. 2002;446(1-3):89-96.
Gurtman, C. G., Morley, K. C., Li, K. M., Hunt, G. E., & McGregor, I. S. (2002). Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. European Journal of Pharmacology, 446(1-3), 89-96.
Gurtman CG, et al. Increased Anxiety in Rats After 3,4-methylenedioxymethamphetamine: Association With Serotonin Depletion. Eur J Pharmacol. 2002 Jun 20;446(1-3):89-96. PubMed PMID: 12098589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. AU - Gurtman,Clint G, AU - Morley,Kirsten C, AU - Li,Kong M, AU - Hunt,Glenn E, AU - McGregor,Iain S, PY - 2002/7/6/pubmed PY - 2003/1/9/medline PY - 2002/7/6/entrez SP - 89 EP - 96 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 446 IS - 1-3 N2 - The long-term behavioural and neurotoxic effects of 3,4-methlyenedioxymethampthetamine (MDMA, "Ecstasy") were examined in rats. Rats were given MDMA (5 mg/kg i.p. once per hour for 4 h) or vehicle injections on each of two consecutive days at an ambient temparature of 28 degrees C. MDMA caused acute hyperthermia and locomotor hyperactivity on both days. Four and six weeks after drug administration the rats previously treated with MDMA showed elevated levels of anxiety-like behaviour in the emergence and social interaction tests, respectively. At 9 weeks post-MDMA, the rats displayed an increase in anxiety on the elevated plus-maze test relative to controls. Ten weeks following treatment the rats were killed and their brains dissected and neurotramitter content analysed using High Performance Liquid Chromotography (HPLC). Rats previously given MDMA showed significantly decreased 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the amygdala, hippocampus and striatum relative to controls. This 5-HT depletion may have a causal role in producing increased anxiety-like behaviours in MDMA-treated rats. These results are consistent with human studies suggesting that exposure to high doses of MDMA may predispose to long-term psychological problems such as anxiety and depression. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/12098589/Increased_anxiety_in_rats_after_34_methylenedioxymethamphetamine:_association_with_serotonin_depletion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299902018204 DB - PRIME DP - Unbound Medicine ER -