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Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors.

Abstract

To ascertain the potential contribution of serum lipids to the development of deep vein thrombosis (DVT), a case-control study was conducted in 143 DVT patients lacking thrombophilic risk factors and in 194 age- and sex-matched controls. DVT patients showed significantly higher body mass indices (BMI), and triglyceride levels than did controls (P < 0.001 and P = 0.045 respectively). Using multivariate analysis, BMI was the only variable which remained statistically different, thus the risk of DVT was associated with obesity (odds ratio = 2.49). These results were confirmed when additional control for fibrinogen and plasminogen activator inhibitor type 1 (PAI-1) was carried out in a subgroup of cases and controls. When idiopathic (n = 39) and secondary (n = 104) patients with DVT were compared, the former showed a higher mean age, a higher proportion of men, and higher cholesterol levels. Age, sex and total cholesterol were statistically different by multivariate analysis. After age was dichotomized as >or= 50 years and cholesterol >or= 5.69 mmol/l, all three variables constituted independent risk factors for idiopathic DVT, with odds ratios of 2.73 for ages >or= 50 years; 3.72 for men and 2.67 for cholesterolaemia >or= 5.69 mmol/l. Obesity thus constitutes an independent risk factor for DVT, possibly in part mediated through triglyceride, fibrinogen and PAI-1 effects on haemostasis. In addition, cholesterolaemia levels of >or= 5.69 mmol/l constitute an independent risk factor for idiopathic DVT.

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  • Authors+Show Affiliations

    ,

    Thrombosis and Hemostasis Unit, Department of Clinical Pathology, Thrombosis Research Center, La Fe University Hospital, Valencia, Spain. vaya_amp@gva.es

    , , , , , ,

    Source

    British journal of haematology 118:1 2002 Jul pg 255-9

    MeSH

    Adult
    Age Factors
    Body Mass Index
    Case-Control Studies
    Cholesterol
    Female
    Fibrinogen
    Humans
    Hyperlipidemias
    Male
    Middle Aged
    Multivariate Analysis
    Plasminogen Activator Inhibitor 1
    Pulmonary Embolism
    Risk Factors
    Sex Factors
    Triglycerides
    Venous Thrombosis

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12100157

    Citation

    Vayá, Amparo, et al. "Hyperlipidaemia and Venous Thromboembolism in Patients Lacking Thrombophilic Risk Factors." British Journal of Haematology, vol. 118, no. 1, 2002, pp. 255-9.
    Vayá A, Mira Y, Ferrando F, et al. Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors. Br J Haematol. 2002;118(1):255-9.
    Vayá, A., Mira, Y., Ferrando, F., Contreras, M., Estelles, A., España, F., ... Aznar, J. (2002). Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors. British Journal of Haematology, 118(1), pp. 255-9.
    Vayá A, et al. Hyperlipidaemia and Venous Thromboembolism in Patients Lacking Thrombophilic Risk Factors. Br J Haematol. 2002;118(1):255-9. PubMed PMID: 12100157.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors. AU - Vayá,Amparo, AU - Mira,Yolanda, AU - Ferrando,Fernando, AU - Contreras,MaTeresa, AU - Estelles,Amparo, AU - España,Francisco, AU - Corella,Dolores, AU - Aznar,Justo, PY - 2002/7/9/pubmed PY - 2002/9/12/medline PY - 2002/7/9/entrez SP - 255 EP - 9 JF - British journal of haematology JO - Br. J. Haematol. VL - 118 IS - 1 N2 - To ascertain the potential contribution of serum lipids to the development of deep vein thrombosis (DVT), a case-control study was conducted in 143 DVT patients lacking thrombophilic risk factors and in 194 age- and sex-matched controls. DVT patients showed significantly higher body mass indices (BMI), and triglyceride levels than did controls (P < 0.001 and P = 0.045 respectively). Using multivariate analysis, BMI was the only variable which remained statistically different, thus the risk of DVT was associated with obesity (odds ratio = 2.49). These results were confirmed when additional control for fibrinogen and plasminogen activator inhibitor type 1 (PAI-1) was carried out in a subgroup of cases and controls. When idiopathic (n = 39) and secondary (n = 104) patients with DVT were compared, the former showed a higher mean age, a higher proportion of men, and higher cholesterol levels. Age, sex and total cholesterol were statistically different by multivariate analysis. After age was dichotomized as >or= 50 years and cholesterol >or= 5.69 mmol/l, all three variables constituted independent risk factors for idiopathic DVT, with odds ratios of 2.73 for ages >or= 50 years; 3.72 for men and 2.67 for cholesterolaemia >or= 5.69 mmol/l. Obesity thus constitutes an independent risk factor for DVT, possibly in part mediated through triglyceride, fibrinogen and PAI-1 effects on haemostasis. In addition, cholesterolaemia levels of >or= 5.69 mmol/l constitute an independent risk factor for idiopathic DVT. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/12100157/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1048&amp;date=2002&amp;volume=118&amp;issue=1&amp;spage=255 DB - PRIME DP - Unbound Medicine ER -