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The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion.
Brain Res. 2002 Jul 12; 943(2):287-91.BR

Abstract

The co-expression of ASIC3 with calcitonin gene-related peptide (CGRP) or parvalbumin (PV) was examined in the trigeminal ganglion (TG) by a double immunofluorescence method. ASIC3-immunoreactivity (IR) was detected in 23% of TG neurons. These neurons were of various sizes (range= 43-1768 microm(2), mean+/-S.D.=651+/-356 microm(2)); 26% and 14% of ASIC3-immunoreactive (IR) neurons co-expressed CGRP- and PV-immunoreactivity (IR), respectively; 33% and 13% of the TG neurons retrogradely labeled from the tooth pulp and facial skin, respectively, exhibited ASIC3-IR; 36% of CGRP-IR TG neurons which innervate these tissues co-expressed ASIC3-IR. Only 4% of ASIC3-IR cutaneous TG neurons showed PV-IR, while 25% of ASIC3-IR tooth pulp neurons were also immunoreactive for PV. The present study suggests that ASIC3-IR TG neurons supply the tooth pulp and facial skin with unmyelinated or finely myelinated axons. ASIC3-IR neurons which have large myelinated axons may be common in the tooth pulp but not the facial skin. The axonal morphology of ASIC3-IR TG neurons may depend on the variety of their receptive fields.

Authors+Show Affiliations

Department of Oral Function and Anatomy and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@md.okayama-u.ac.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12101052

Citation

Ichikawa, Hiroichi, and T Sugimoto. "The Co-expression of ASIC3 With Calcitonin Gene-related Peptide and Parvalbumin in the Rat Trigeminal Ganglion." Brain Research, vol. 943, no. 2, 2002, pp. 287-91.
Ichikawa H, Sugimoto T. The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion. Brain Res. 2002;943(2):287-91.
Ichikawa, H., & Sugimoto, T. (2002). The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion. Brain Research, 943(2), 287-91.
Ichikawa H, Sugimoto T. The Co-expression of ASIC3 With Calcitonin Gene-related Peptide and Parvalbumin in the Rat Trigeminal Ganglion. Brain Res. 2002 Jul 12;943(2):287-91. PubMed PMID: 12101052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion. AU - Ichikawa,Hiroichi, AU - Sugimoto,T, PY - 2002/7/9/pubmed PY - 2002/9/28/medline PY - 2002/7/9/entrez SP - 287 EP - 91 JF - Brain research JO - Brain Res. VL - 943 IS - 2 N2 - The co-expression of ASIC3 with calcitonin gene-related peptide (CGRP) or parvalbumin (PV) was examined in the trigeminal ganglion (TG) by a double immunofluorescence method. ASIC3-immunoreactivity (IR) was detected in 23% of TG neurons. These neurons were of various sizes (range= 43-1768 microm(2), mean+/-S.D.=651+/-356 microm(2)); 26% and 14% of ASIC3-immunoreactive (IR) neurons co-expressed CGRP- and PV-immunoreactivity (IR), respectively; 33% and 13% of the TG neurons retrogradely labeled from the tooth pulp and facial skin, respectively, exhibited ASIC3-IR; 36% of CGRP-IR TG neurons which innervate these tissues co-expressed ASIC3-IR. Only 4% of ASIC3-IR cutaneous TG neurons showed PV-IR, while 25% of ASIC3-IR tooth pulp neurons were also immunoreactive for PV. The present study suggests that ASIC3-IR TG neurons supply the tooth pulp and facial skin with unmyelinated or finely myelinated axons. ASIC3-IR neurons which have large myelinated axons may be common in the tooth pulp but not the facial skin. The axonal morphology of ASIC3-IR TG neurons may depend on the variety of their receptive fields. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/12101052/The_co_expression_of_ASIC3_with_calcitonin_gene_related_peptide_and_parvalbumin_in_the_rat_trigeminal_ganglion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006899302028317 DB - PRIME DP - Unbound Medicine ER -