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Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion.
Eur Cytokine Netw. 2002 Apr-Jun; 13(2):161-72.EC

Abstract

Inflammation in the middle ear mucosa, caused usually by bacterial and viral pathogens, is the primary event in the middle ear predisposing the development of otitis media with effusion (OME). Numerous inflammatory mediators have been identified in OME. However, cytokines play a central role as initiators, mediators and regulators of middle ear inflammation and subsequent molecular-pathological processes in middle ear tissues, leading to histopathological changes in the middle ear cavity and the pathogenesis of OME. In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion.

Authors+Show Affiliations

Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. Marina.Smirnova@ncl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12101072

Citation

Smirnova, Marina G., et al. "Role of the Pro-inflammatory Cytokines Tumor Necrosis Factor-alpha, Interleukin-1 Beta, Interleukin-6 and Interleukin-8 in the Pathogenesis of the Otitis Media With Effusion." European Cytokine Network, vol. 13, no. 2, 2002, pp. 161-72.
Smirnova MG, Kiselev SL, Gnuchev NV, et al. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. Eur Cytokine Netw. 2002;13(2):161-72.
Smirnova, M. G., Kiselev, S. L., Gnuchev, N. V., Birchall, J. P., & Pearson, J. P. (2002). Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. European Cytokine Network, 13(2), 161-72.
Smirnova MG, et al. Role of the Pro-inflammatory Cytokines Tumor Necrosis Factor-alpha, Interleukin-1 Beta, Interleukin-6 and Interleukin-8 in the Pathogenesis of the Otitis Media With Effusion. Eur Cytokine Netw. 2002 Apr-Jun;13(2):161-72. PubMed PMID: 12101072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. AU - Smirnova,Marina G, AU - Kiselev,Sergei L, AU - Gnuchev,Nickolai V, AU - Birchall,John P, AU - Pearson,Jeffrey P, PY - 2002/7/9/pubmed PY - 2003/1/22/medline PY - 2002/7/9/entrez SP - 161 EP - 72 JF - European cytokine network JO - Eur Cytokine Netw VL - 13 IS - 2 N2 - Inflammation in the middle ear mucosa, caused usually by bacterial and viral pathogens, is the primary event in the middle ear predisposing the development of otitis media with effusion (OME). Numerous inflammatory mediators have been identified in OME. However, cytokines play a central role as initiators, mediators and regulators of middle ear inflammation and subsequent molecular-pathological processes in middle ear tissues, leading to histopathological changes in the middle ear cavity and the pathogenesis of OME. In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion. SN - 1148-5493 UR - https://www.unboundmedicine.com/medline/citation/12101072/Role_of_the_pro_inflammatory_cytokines_tumor_necrosis_factor_alpha_interleukin_1_beta_interleukin_6_and_interleukin_8_in_the_pathogenesis_of_the_otitis_media_with_effusion_ L2 - http://www.jle.com/medline.md?issn=1148-5493&vol=13&iss=2&page=161 DB - PRIME DP - Unbound Medicine ER -