Tags

Type your tag names separated by a space and hit enter

Anal achalasia after pull-through operations for Hirschsprung's disease -- preliminary experience with topical nitric oxide.
Eur J Pediatr Surg. 2002 Jun; 12(3):207-11.EJ

Abstract

INTRODUCTION

Following definitive pull-through for Hirschsprung's disease (HD), a minority of patients develop constipation, incontinence and enterocolitis. The cause for these symptoms in some of the patients is believed to be "internal sphincter achalasia" related to abnormal innervation of the sphincter, with an absent anorectal relaxation reflex. Transanal myectomy, posterior sagittal rectal myectomy, anal dilatation and even intrasphincter injection of botulinum toxin have been used to solve this problem. Nitric oxide (NO) has been identified as the chemical messenger of the intrinsic non-adrenergic, non-cholinergic pathway mediating relaxation of the normal internal anal sphincter when applied topically.

BACKGROUND/PURPOSE

To evaluate the effect of topical isosorbide dinitrate (DTN) applied to the anus and its role in the management of patients with HD after pull-through who have ongoing difficulties in stool evacuation.

MATERIAL AND METHODS

Four children, aged 2, 5, 7 and 13 years, who all underwent the Soave operation for Hirschsprung's disease, were assessed. Three patients had recurrent episodes of enterocolitis, and all had symptoms of difficulty in rectal/colonic evacuation. Conservative treatment of repeated anal dilatation under anaesthesia had failed to improve symptoms. A rectal myectomy and conversion of Soave to Duhamel procedure had been done in 2 without significant improvement in symptoms. In all patients, ano-rectal manometry was performed before and after application of DTN paste (1 mg/kg/day in two separate doses) which was continued for a minimum period of 3 weeks. Results. Marked symptom improvement was noted in all 4 children. On manometric assessment the median maximum pressure (pre-DTN application) was 165 mm Hg (range 96 - 250), the median sphincter length 2.7 cm (range 2.3 - 3.1) and the high-pressure zone (HPZ) median length 1.6 cm (range 1.2 - 2.1). After application of DTN paste, the maximum pressure dropped by a median of 88 mm Hg (range 46 - 90), total sphincter length shortened to a median of 2.1 cm and the HPZ by a median total length of 1.4 cm (range 0.01 - 0.9). In addition, vector volume was reduced by a median of 59 % (range 40.5 - 77).

CONCLUSION

From these results, it is evident that DTN paste is not only an adjunct in the investigation, but can also be used as a temporary form of treatment of obstructive symptoms in Hirschsprung's disease patients.

Authors+Show Affiliations

Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital & Institute of Child Health, University of Cape Town, Rondebosch, Cape Town, South Africa. amillar@ich.uct.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12101506

Citation

Millar, A J W., et al. "Anal Achalasia After Pull-through Operations for Hirschsprung's Disease -- Preliminary Experience With Topical Nitric Oxide." European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, vol. 12, no. 3, 2002, pp. 207-11.
Millar AJ, Steinberg RM, Raad J, et al. Anal achalasia after pull-through operations for Hirschsprung's disease -- preliminary experience with topical nitric oxide. Eur J Pediatr Surg. 2002;12(3):207-11.
Millar, A. J., Steinberg, R. M., Raad, J., & Rode, H. (2002). Anal achalasia after pull-through operations for Hirschsprung's disease -- preliminary experience with topical nitric oxide. European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 12(3), 207-11.
Millar AJ, et al. Anal Achalasia After Pull-through Operations for Hirschsprung's Disease -- Preliminary Experience With Topical Nitric Oxide. Eur J Pediatr Surg. 2002;12(3):207-11. PubMed PMID: 12101506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anal achalasia after pull-through operations for Hirschsprung's disease -- preliminary experience with topical nitric oxide. AU - Millar,A J W, AU - Steinberg,R M, AU - Raad,J, AU - Rode,H, PY - 2002/7/9/pubmed PY - 2002/9/7/medline PY - 2002/7/9/entrez SP - 207 EP - 11 JF - European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie JO - Eur J Pediatr Surg VL - 12 IS - 3 N2 - INTRODUCTION: Following definitive pull-through for Hirschsprung's disease (HD), a minority of patients develop constipation, incontinence and enterocolitis. The cause for these symptoms in some of the patients is believed to be "internal sphincter achalasia" related to abnormal innervation of the sphincter, with an absent anorectal relaxation reflex. Transanal myectomy, posterior sagittal rectal myectomy, anal dilatation and even intrasphincter injection of botulinum toxin have been used to solve this problem. Nitric oxide (NO) has been identified as the chemical messenger of the intrinsic non-adrenergic, non-cholinergic pathway mediating relaxation of the normal internal anal sphincter when applied topically. BACKGROUND/PURPOSE: To evaluate the effect of topical isosorbide dinitrate (DTN) applied to the anus and its role in the management of patients with HD after pull-through who have ongoing difficulties in stool evacuation. MATERIAL AND METHODS: Four children, aged 2, 5, 7 and 13 years, who all underwent the Soave operation for Hirschsprung's disease, were assessed. Three patients had recurrent episodes of enterocolitis, and all had symptoms of difficulty in rectal/colonic evacuation. Conservative treatment of repeated anal dilatation under anaesthesia had failed to improve symptoms. A rectal myectomy and conversion of Soave to Duhamel procedure had been done in 2 without significant improvement in symptoms. In all patients, ano-rectal manometry was performed before and after application of DTN paste (1 mg/kg/day in two separate doses) which was continued for a minimum period of 3 weeks. Results. Marked symptom improvement was noted in all 4 children. On manometric assessment the median maximum pressure (pre-DTN application) was 165 mm Hg (range 96 - 250), the median sphincter length 2.7 cm (range 2.3 - 3.1) and the high-pressure zone (HPZ) median length 1.6 cm (range 1.2 - 2.1). After application of DTN paste, the maximum pressure dropped by a median of 88 mm Hg (range 46 - 90), total sphincter length shortened to a median of 2.1 cm and the HPZ by a median total length of 1.4 cm (range 0.01 - 0.9). In addition, vector volume was reduced by a median of 59 % (range 40.5 - 77). CONCLUSION: From these results, it is evident that DTN paste is not only an adjunct in the investigation, but can also be used as a temporary form of treatment of obstructive symptoms in Hirschsprung's disease patients. SN - 0939-7248 UR - https://www.unboundmedicine.com/medline/citation/12101506/Anal_achalasia_after_pull_through_operations_for_Hirschsprung's_disease____preliminary_experience_with_topical_nitric_oxide_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-32722 DB - PRIME DP - Unbound Medicine ER -