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Age-related changes in fatty acids in obese offspring of streptozotocin-induced diabetic rats.

Abstract

OBJECTIVE

The long-term effects of fetal hyperinsulinemia, time course of changes in liver and very-low-density lipoprotein (VLDL) lipid levels and fatty acid compositions were investigated in obese offspring of streptozotocin-induced mildly diabetic rats.

RESEARCH METHODS AND PROCEDURES

Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. Liver and VLDL lipids and fatty acids were analyzed in offspring at different ages.

RESULTS

At birth, obese pups had higher VLDL triglyceride levels, saturated fatty acids, and C20:4n-6. They also had lower C18:2n-6 proportions in VLDL triglycerides, phospholipids, and cholesteryl esters than controls pups. In 1-month-old male and female obese rats, VLDL and liver lipid amounts were similar to those in their respective controls; however, high levels of C18:2n-6 and C20:4n-6 were noted in liver and VLDL lipids. At the age of 2 months, liver and VLDL triglyceride levels were higher in obese females than in control females. Fatty acid abnormalities seen in obese rats included low C18:3n-3 and high C22:6n-3 proportions in liver triglycerides and phospholipids. At the age of 3 months, obese rats, both males and females, compared with control animals, had higher VLDL and hepatic lipids with reduced C20:4n-6 levels and polyunsaturated/saturated fatty acids ratios in hepatic and VLDL triglycerides and phospholipids.

DISCUSSION

Fetal obesity, associated with alterations in VLDL lipid fatty acid composition, represents an important risk factor for adult obesity and diabetes.

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  • Authors+Show Affiliations

    ,

    Laboratory of Animal Physiology, Tlemcen University, Tlemcen, Algeria.

    , , , ,

    Source

    Obesity research 10:7 2002 Jul pg 703-14

    MeSH

    Aging
    Animals
    Cholesterol Esters
    Diabetes Mellitus, Experimental
    Fatty Acids
    Female
    Gestational Age
    Lipids
    Lipoproteins, VLDL
    Liver
    Male
    Obesity
    Phospholipids
    Pregnancy
    Pregnancy in Diabetics
    Prenatal Exposure Delayed Effects
    Rats
    Rats, Wistar
    Triglycerides

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12105294

    Citation

    Merzouk, Hafida, et al. "Age-related Changes in Fatty Acids in Obese Offspring of Streptozotocin-induced Diabetic Rats." Obesity Research, vol. 10, no. 7, 2002, pp. 703-14.
    Merzouk H, Madani S, Hichami A, et al. Age-related changes in fatty acids in obese offspring of streptozotocin-induced diabetic rats. Obes Res. 2002;10(7):703-14.
    Merzouk, H., Madani, S., Hichami, A., Prost, J., Belleville, J., & Khan, N. A. (2002). Age-related changes in fatty acids in obese offspring of streptozotocin-induced diabetic rats. Obesity Research, 10(7), pp. 703-14.
    Merzouk H, et al. Age-related Changes in Fatty Acids in Obese Offspring of Streptozotocin-induced Diabetic Rats. Obes Res. 2002;10(7):703-14. PubMed PMID: 12105294.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Age-related changes in fatty acids in obese offspring of streptozotocin-induced diabetic rats. AU - Merzouk,Hafida, AU - Madani,Sihem, AU - Hichami,Aziz, AU - Prost,Josiane, AU - Belleville,Jacques, AU - Khan,Naim A, PY - 2002/7/10/pubmed PY - 2003/1/8/medline PY - 2002/7/10/entrez SP - 703 EP - 14 JF - Obesity research JO - Obes. Res. VL - 10 IS - 7 N2 - OBJECTIVE: The long-term effects of fetal hyperinsulinemia, time course of changes in liver and very-low-density lipoprotein (VLDL) lipid levels and fatty acid compositions were investigated in obese offspring of streptozotocin-induced mildly diabetic rats. RESEARCH METHODS AND PROCEDURES: Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. Liver and VLDL lipids and fatty acids were analyzed in offspring at different ages. RESULTS: At birth, obese pups had higher VLDL triglyceride levels, saturated fatty acids, and C20:4n-6. They also had lower C18:2n-6 proportions in VLDL triglycerides, phospholipids, and cholesteryl esters than controls pups. In 1-month-old male and female obese rats, VLDL and liver lipid amounts were similar to those in their respective controls; however, high levels of C18:2n-6 and C20:4n-6 were noted in liver and VLDL lipids. At the age of 2 months, liver and VLDL triglyceride levels were higher in obese females than in control females. Fatty acid abnormalities seen in obese rats included low C18:3n-3 and high C22:6n-3 proportions in liver triglycerides and phospholipids. At the age of 3 months, obese rats, both males and females, compared with control animals, had higher VLDL and hepatic lipids with reduced C20:4n-6 levels and polyunsaturated/saturated fatty acids ratios in hepatic and VLDL triglycerides and phospholipids. DISCUSSION: Fetal obesity, associated with alterations in VLDL lipid fatty acid composition, represents an important risk factor for adult obesity and diabetes. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12105294/Age_related_changes_in_fatty_acids_in_obese_offspring_of_streptozotocin_induced_diabetic_rats_ L2 - https://doi.org/10.1038/oby.2002.95 DB - PRIME DP - Unbound Medicine ER -