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Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach.
Free Radic Biol Med. 2002 Jul 15; 33(2):182-91.FR

Abstract

Various neurodegenerative disorders and syndromes are associated with oxidative stress. The deleterious consequences of excessive oxidations and the pathophysiological role of reactive oxygen species (ROS) have been intensively studied in Alzheimer's disease (AD). Neuronal cell dysfunction and oxidative cell death caused by the AD-associated amyloid beta protein may causally contribute to the pathogenesis of AD. Antioxidants that prevent the detrimental consequences of ROS are consequently considered to be a promising approach to neuroprotection. While there is ample experimental evidence demonstrating neuroprotective activities of antioxidants in vitro, the clinical evidence that antioxidant compounds act as protective drugs is still relatively scarce. Nevertheless, antioxidants constitute a major part of the panel of clinical and experimental drugs that are currently considered for AD prevention and therapy. Here, focus is put mainly on phenolic antioxidant structures that belong to the class of direct antioxidants. Experimental and clinical evidence for the neuroprotective potential of alpha-tocopherol (vitamin E) and 17beta-estradiol (estrogen) is shortly summarized and an outlook is given on possible novel antioxidant lead structures with improved pharmacological features.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Munich, Germany. chris@mpipsykl.mpg.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12106814

Citation

Behl, Christian, and Bernd Moosmann. "Antioxidant Neuroprotection in Alzheimer's Disease as Preventive and Therapeutic Approach." Free Radical Biology & Medicine, vol. 33, no. 2, 2002, pp. 182-91.
Behl C, Moosmann B. Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radic Biol Med. 2002;33(2):182-91.
Behl, C., & Moosmann, B. (2002). Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radical Biology & Medicine, 33(2), 182-91.
Behl C, Moosmann B. Antioxidant Neuroprotection in Alzheimer's Disease as Preventive and Therapeutic Approach. Free Radic Biol Med. 2002 Jul 15;33(2):182-91. PubMed PMID: 12106814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. AU - Behl,Christian, AU - Moosmann,Bernd, PY - 2002/7/11/pubmed PY - 2003/1/11/medline PY - 2002/7/11/entrez SP - 182 EP - 91 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 33 IS - 2 N2 - Various neurodegenerative disorders and syndromes are associated with oxidative stress. The deleterious consequences of excessive oxidations and the pathophysiological role of reactive oxygen species (ROS) have been intensively studied in Alzheimer's disease (AD). Neuronal cell dysfunction and oxidative cell death caused by the AD-associated amyloid beta protein may causally contribute to the pathogenesis of AD. Antioxidants that prevent the detrimental consequences of ROS are consequently considered to be a promising approach to neuroprotection. While there is ample experimental evidence demonstrating neuroprotective activities of antioxidants in vitro, the clinical evidence that antioxidant compounds act as protective drugs is still relatively scarce. Nevertheless, antioxidants constitute a major part of the panel of clinical and experimental drugs that are currently considered for AD prevention and therapy. Here, focus is put mainly on phenolic antioxidant structures that belong to the class of direct antioxidants. Experimental and clinical evidence for the neuroprotective potential of alpha-tocopherol (vitamin E) and 17beta-estradiol (estrogen) is shortly summarized and an outlook is given on possible novel antioxidant lead structures with improved pharmacological features. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/12106814/Antioxidant_neuroprotection_in_Alzheimer's_disease_as_preventive_and_therapeutic_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891584902008833 DB - PRIME DP - Unbound Medicine ER -