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[Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)].
Eksp Klin Farmakol. 2002 Mar-Apr; 65(2):53-5.EK

Abstract

It is established that single intravenous (0.5 and 5 mg/kg, p.o.) or single peroral (10, 50, 100 mg/kg) and prolonged peroral (5 mg/kg, over 10 days) administration of noopept produces a dose-dependent inhibition of the model inflammatory response to concanavaline A in CBA mice. Intravenously injected (5 mg/kg) noopept suppressed the acute nonimmune carrageenan-induced foot inflammation in rats by 62.2% within 3 h. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively). The in vitro experiments with neutrophilic leukocytes of F1(CBA.C57BL/6) mice treated with noopept in a single dose of 5 mg/kg (i.v.) showed a 5- to 6-fold suppression of the hemiluminescence stimulated by opsoinized zymosan or phorbolmyristate acetate. It is suggested that the antiinflammatory activity of noopept is probably related to its antioxidant properties.

Authors+Show Affiliations

Laboratory of Drug Toxicology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

rus

PubMed ID

12109295

Citation

Kovalenko, L P., et al. "[Anti-inflammatory Properties of Noopept (dipeptide Nootropic Agent GVS-111)]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 65, no. 2, 2002, pp. 53-5.
Kovalenko LP, Miramedova MG, Alekseeva SV, et al. [Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)]. Eksp Klin Farmakol. 2002;65(2):53-5.
Kovalenko, L. P., Miramedova, M. G., Alekseeva, S. V., Gudasheva, T. A., Ostrovskaia, R. U., & Seredenin, S. B. (2002). [Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)]. Eksperimental'naia I Klinicheskaia Farmakologiia, 65(2), 53-5.
Kovalenko LP, et al. [Anti-inflammatory Properties of Noopept (dipeptide Nootropic Agent GVS-111)]. Eksp Klin Farmakol. 2002 Mar-Apr;65(2):53-5. PubMed PMID: 12109295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)]. AU - Kovalenko,L P, AU - Miramedova,M G, AU - Alekseeva,S V, AU - Gudasheva,T A, AU - Ostrovskaia,R U, AU - Seredenin,S B, PY - 2002/7/12/pubmed PY - 2002/8/20/medline PY - 2002/7/12/entrez SP - 53 EP - 5 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 65 IS - 2 N2 - It is established that single intravenous (0.5 and 5 mg/kg, p.o.) or single peroral (10, 50, 100 mg/kg) and prolonged peroral (5 mg/kg, over 10 days) administration of noopept produces a dose-dependent inhibition of the model inflammatory response to concanavaline A in CBA mice. Intravenously injected (5 mg/kg) noopept suppressed the acute nonimmune carrageenan-induced foot inflammation in rats by 62.2% within 3 h. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively). The in vitro experiments with neutrophilic leukocytes of F1(CBA.C57BL/6) mice treated with noopept in a single dose of 5 mg/kg (i.v.) showed a 5- to 6-fold suppression of the hemiluminescence stimulated by opsoinized zymosan or phorbolmyristate acetate. It is suggested that the antiinflammatory activity of noopept is probably related to its antioxidant properties. SN - 0869-2092 UR - https://www.unboundmedicine.com/medline/citation/12109295/[Anti_inflammatory_properties_of_noopept__dipeptide_nootropic_agent_GVS_111 L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -