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The continued pandemic threat posed by avian influenza viruses in Hong Kong.

Abstract

In 1997, a highly pathogenic avian H5N1 influenza virus was transmitted directly from live commercial poultry to humans in Hong Kong. Of the 18 people infected, six died. The molecular basis for the high virulence of this virus in mice was found to involve an amino acid change in the PB2 protein. To eliminate the source of the pathogenic virus, all birds in the Hong Kong markets were slaughtered. In 1999, another avian influenza virus of H9N2 subtype was transmitted to two children in Hong Kong. In 2000-2002, H5N1 avian viruses reappeared in the poultry markets of Hong Kong, although they have not infected humans. Continued circulation of H5N1 and other avian viruses in Hong Kong raises the possibility of future human influenza outbreaks. Moreover, the acquisition of properties of human viruses by the avian viruses currently circulating in southeast China might result in a pandemic.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.

    Source

    Trends in microbiology 10:7 2002 Jul pg 340-4

    MeSH

    Animals
    Communicable Diseases, Emerging
    Disease Outbreaks
    Disease Reservoirs
    Hong Kong
    Humans
    Influenza A Virus, H5N1 Subtype
    Influenza in Birds
    Influenza, Human
    Mice
    Poultry
    Virulence

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    12110213

    Citation

    Hatta, Masato, and Yoshihiro Kawaoka. "The Continued Pandemic Threat Posed By Avian Influenza Viruses in Hong Kong." Trends in Microbiology, vol. 10, no. 7, 2002, pp. 340-4.
    Hatta M, Kawaoka Y. The continued pandemic threat posed by avian influenza viruses in Hong Kong. Trends Microbiol. 2002;10(7):340-4.
    Hatta, M., & Kawaoka, Y. (2002). The continued pandemic threat posed by avian influenza viruses in Hong Kong. Trends in Microbiology, 10(7), pp. 340-4.
    Hatta M, Kawaoka Y. The Continued Pandemic Threat Posed By Avian Influenza Viruses in Hong Kong. Trends Microbiol. 2002;10(7):340-4. PubMed PMID: 12110213.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The continued pandemic threat posed by avian influenza viruses in Hong Kong. AU - Hatta,Masato, AU - Kawaoka,Yoshihiro, PY - 2002/7/12/pubmed PY - 2002/8/14/medline PY - 2002/7/12/entrez SP - 340 EP - 4 JF - Trends in microbiology JO - Trends Microbiol. VL - 10 IS - 7 N2 - In 1997, a highly pathogenic avian H5N1 influenza virus was transmitted directly from live commercial poultry to humans in Hong Kong. Of the 18 people infected, six died. The molecular basis for the high virulence of this virus in mice was found to involve an amino acid change in the PB2 protein. To eliminate the source of the pathogenic virus, all birds in the Hong Kong markets were slaughtered. In 1999, another avian influenza virus of H9N2 subtype was transmitted to two children in Hong Kong. In 2000-2002, H5N1 avian viruses reappeared in the poultry markets of Hong Kong, although they have not infected humans. Continued circulation of H5N1 and other avian viruses in Hong Kong raises the possibility of future human influenza outbreaks. Moreover, the acquisition of properties of human viruses by the avian viruses currently circulating in southeast China might result in a pandemic. SN - 0966-842X UR - https://www.unboundmedicine.com/medline/citation/12110213/The_continued_pandemic_threat_posed_by_avian_influenza_viruses_in_Hong_Kong_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966842X02023880 DB - PRIME DP - Unbound Medicine ER -