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The continued pandemic threat posed by avian influenza viruses in Hong Kong.
Trends Microbiol 2002; 10(7):340-4TM

Abstract

In 1997, a highly pathogenic avian H5N1 influenza virus was transmitted directly from live commercial poultry to humans in Hong Kong. Of the 18 people infected, six died. The molecular basis for the high virulence of this virus in mice was found to involve an amino acid change in the PB2 protein. To eliminate the source of the pathogenic virus, all birds in the Hong Kong markets were slaughtered. In 1999, another avian influenza virus of H9N2 subtype was transmitted to two children in Hong Kong. In 2000-2002, H5N1 avian viruses reappeared in the poultry markets of Hong Kong, although they have not infected humans. Continued circulation of H5N1 and other avian viruses in Hong Kong raises the possibility of future human influenza outbreaks. Moreover, the acquisition of properties of human viruses by the avian viruses currently circulating in southeast China might result in a pandemic.

Authors+Show Affiliations

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12110213

Citation

Hatta, Masato, and Yoshihiro Kawaoka. "The Continued Pandemic Threat Posed By Avian Influenza Viruses in Hong Kong." Trends in Microbiology, vol. 10, no. 7, 2002, pp. 340-4.
Hatta M, Kawaoka Y. The continued pandemic threat posed by avian influenza viruses in Hong Kong. Trends Microbiol. 2002;10(7):340-4.
Hatta, M., & Kawaoka, Y. (2002). The continued pandemic threat posed by avian influenza viruses in Hong Kong. Trends in Microbiology, 10(7), pp. 340-4.
Hatta M, Kawaoka Y. The Continued Pandemic Threat Posed By Avian Influenza Viruses in Hong Kong. Trends Microbiol. 2002;10(7):340-4. PubMed PMID: 12110213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The continued pandemic threat posed by avian influenza viruses in Hong Kong. AU - Hatta,Masato, AU - Kawaoka,Yoshihiro, PY - 2002/7/12/pubmed PY - 2002/8/14/medline PY - 2002/7/12/entrez SP - 340 EP - 4 JF - Trends in microbiology JO - Trends Microbiol. VL - 10 IS - 7 N2 - In 1997, a highly pathogenic avian H5N1 influenza virus was transmitted directly from live commercial poultry to humans in Hong Kong. Of the 18 people infected, six died. The molecular basis for the high virulence of this virus in mice was found to involve an amino acid change in the PB2 protein. To eliminate the source of the pathogenic virus, all birds in the Hong Kong markets were slaughtered. In 1999, another avian influenza virus of H9N2 subtype was transmitted to two children in Hong Kong. In 2000-2002, H5N1 avian viruses reappeared in the poultry markets of Hong Kong, although they have not infected humans. Continued circulation of H5N1 and other avian viruses in Hong Kong raises the possibility of future human influenza outbreaks. Moreover, the acquisition of properties of human viruses by the avian viruses currently circulating in southeast China might result in a pandemic. SN - 0966-842X UR - https://www.unboundmedicine.com/medline/citation/12110213/The_continued_pandemic_threat_posed_by_avian_influenza_viruses_in_Hong_Kong_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966842X02023880 DB - PRIME DP - Unbound Medicine ER -