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Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women.
J Mol Med (Berl). 2002 Jul; 80(7):452-60.JM

Abstract

The estrogen receptor alpha gene is a candidate locus for genetic influence on bone mass. The possible association between two polymorphisms in the first intron of this gene, alone or in combination, and bone mineral density at various sites was examined in participants in the National Institute for Longevity Sciences Longitudinal Study of Aging, a population-based prospective cohort study of aging and age-related diseases. The relationship of the TC (PvuII) and AG (XbaI) polymorphisms in the first intron of the estrogen receptor alpha gene to bone mineral density was determined in 2230 subjects (1120 men, 1110 women) and in 2238 subjects (1128 men, 1110 women), respectively, all of whom were community-dwelling individuals aged 40-79 years. Bone mineral density at the radius was measured by peripheral quantitative computed tomography and that for the lumbar spine, right femoral neck, right trochanter, right Ward's triangle, and total body was measured by dual-energy X-ray absorptiometry. Estrogen receptor alpha genotypes were determined with an automated fluorescent allele-specific DNA primer assay system. Analysis of the TC (PvuII) polymorphism revealed that bone mineral density for the total body, femoral neck, and trochanter was significantly lower in women aged 60 years or over with the CC genotype than in those with the TT genotype, but statistical significance was not achieved after adjustment for age, body mass index, and smoking status. Analysis of the AG (XbaI) polymorphism revealed that bone mineral density for the femoral neck was significantly lower in women aged 60 years or over with the GG genotype than in those with the AA genotype. After adjustment for age, body mass index, and smoking status, bone mineral density for the femoral neck was significantly lower in women aged 60 years or over with the GG genotype than in those with the AA or AG genotypes. Analysis of combined genotypes in women aged 60 years or over revealed that bone mineral density for the femoral neck was significantly lower in women with the CC/ GG genotype than in those with the TT/ AA or TC/ AA genotypes. After adjustment for age, body mass index, and smoking status, bone mineral density for the femoral neck was significantly lower in women aged 60 years or over with the CC/ GG genotype than in those with other genotypes. No differences in bone mineral density at the various sites were detected among TC (PvuII), AG (XbaI), or combined genotypes in women aged under 60 years or in men. These results suggest that the estrogen receptor alpha gene is a susceptibility locus for bone mass, especially for the femoral neck, in elderly Japanese women.

Authors+Show Affiliations

Department of Gene Therapy, Gifu International Institute of Biotechnology, and Institute of Applied Biochemistry, Mitake, Gifu 505-0116, Japan. yoyamada@giib.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12110951

Citation

Yamada, Yoshiji, et al. "Association of Polymorphisms of the Estrogen Receptor Alpha Gene With Bone Mineral Density of the Femoral Neck in Elderly Japanese Women." Journal of Molecular Medicine (Berlin, Germany), vol. 80, no. 7, 2002, pp. 452-60.
Yamada Y, Ando F, Niino N, et al. Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med. 2002;80(7):452-60.
Yamada, Y., Ando, F., Niino, N., Ohta, S., & Shimokata, H. (2002). Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. Journal of Molecular Medicine (Berlin, Germany), 80(7), 452-60.
Yamada Y, et al. Association of Polymorphisms of the Estrogen Receptor Alpha Gene With Bone Mineral Density of the Femoral Neck in Elderly Japanese Women. J Mol Med. 2002;80(7):452-60. PubMed PMID: 12110951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. AU - Yamada,Yoshiji, AU - Ando,Fujiko, AU - Niino,Naoakira, AU - Ohta,Shigeo, AU - Shimokata,Hiroshi, Y1 - 2002/06/04/ PY - 2002/01/10/received PY - 2002/04/02/accepted PY - 2002/7/12/pubmed PY - 2003/3/26/medline PY - 2002/7/12/entrez SP - 452 EP - 60 JF - Journal of molecular medicine (Berlin, Germany) JO - J. Mol. Med. VL - 80 IS - 7 N2 - The estrogen receptor alpha gene is a candidate locus for genetic influence on bone mass. The possible association between two polymorphisms in the first intron of this gene, alone or in combination, and bone mineral density at various sites was examined in participants in the National Institute for Longevity Sciences Longitudinal Study of Aging, a population-based prospective cohort study of aging and age-related diseases. The relationship of the TC (PvuII) and AG (XbaI) polymorphisms in the first intron of the estrogen receptor alpha gene to bone mineral density was determined in 2230 subjects (1120 men, 1110 women) and in 2238 subjects (1128 men, 1110 women), respectively, all of whom were community-dwelling individuals aged 40-79 years. Bone mineral density at the radius was measured by peripheral quantitative computed tomography and that for the lumbar spine, right femoral neck, right trochanter, right Ward's triangle, and total body was measured by dual-energy X-ray absorptiometry. Estrogen receptor alpha genotypes were determined with an automated fluorescent allele-specific DNA primer assay system. Analysis of the TC (PvuII) polymorphism revealed that bone mineral density for the total body, femoral neck, and trochanter was significantly lower in women aged 60 years or over with the CC genotype than in those with the TT genotype, but statistical significance was not achieved after adjustment for age, body mass index, and smoking status. Analysis of the AG (XbaI) polymorphism revealed that bone mineral density for the femoral neck was significantly lower in women aged 60 years or over with the GG genotype than in those with the AA genotype. After adjustment for age, body mass index, and smoking status, bone mineral density for the femoral neck was significantly lower in women aged 60 years or over with the GG genotype than in those with the AA or AG genotypes. Analysis of combined genotypes in women aged 60 years or over revealed that bone mineral density for the femoral neck was significantly lower in women with the CC/ GG genotype than in those with the TT/ AA or TC/ AA genotypes. After adjustment for age, body mass index, and smoking status, bone mineral density for the femoral neck was significantly lower in women aged 60 years or over with the CC/ GG genotype than in those with other genotypes. No differences in bone mineral density at the various sites were detected among TC (PvuII), AG (XbaI), or combined genotypes in women aged under 60 years or in men. These results suggest that the estrogen receptor alpha gene is a susceptibility locus for bone mass, especially for the femoral neck, in elderly Japanese women. SN - 0946-2716 UR - https://www.unboundmedicine.com/medline/citation/12110951/Association_of_polymorphisms_of_the_estrogen_receptor_alpha_gene_with_bone_mineral_density_of_the_femoral_neck_in_elderly_Japanese_women_ L2 - https://dx.doi.org/10.1007/s00109-002-0348-0 DB - PRIME DP - Unbound Medicine ER -