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The efficacy of dietary intervention alone or combined with hormone replacement therapy in postmenopausal women with hypercholesterolemia in Seoul, Korea.
Eur J Nutr. 2002 Jun; 41(3):101-7.EJ

Abstract

BACKGROUND

Women have an increased incidence of cardiovascular disease (CVD) due to hormone imbalance-induced changes in blood lipid profiles after menopause.

AIM OF STUDY

This study was done to compare the effects of dietary intervention and hormone replacement therapy, alone or in combination, on blood lipids and body weight in Korean postmenopausal women with hypercholesterolemia.

METHOD

The subjects were treated by one of three different treatments for 12 weeks: hormone replacement therapy (HRT group, n = 8), dietary intervention (DIET group, n = 8) and hormone replacement therapy combined with dietary intervention (HRT+DIET group, n = 8).

RESULTS

Serum TC and LDL-C levels decreased by 13-16 % and 24-28 % in the HRT group, by 17-19 % and 21-23 % in the DIET group and by 19-26 % and 32-39 % in the HRT+DIET group, respectively (P < 0.05). Serum HDL-C levels decreased in the DIET group (-6.4 %, P < 0.05) but not in the HRT and HRT+DIET groups. Serum TG levels increased in the HRT group (18 %, P < 0.05) but decreased in the DIET group (-24.4 %, P < 0.05). In the HRT+ DIET group, serum TG levels did not change. Body weight decreased only in the DIET group.

CONCLUSIONS

We can conclude that dietary intervention produces a considerable improvement in blood lipid profiles and body weight, even though our study is limited by the sample size. Thus, the treatment to reduce risk of CVD should be individualized on the basis of the patient's dietary intake status, and at least, HRT should not be substituted for dietary intervention.

Authors+Show Affiliations

Korean Living Science Research Institute, Hanyang University, 17 Haengdang-dong Sungdong-ku, Seoul, 133-791, Korea. kaj0417@hanmail.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12111046

Citation

Jung, Kyungah, et al. "The Efficacy of Dietary Intervention Alone or Combined With Hormone Replacement Therapy in Postmenopausal Women With Hypercholesterolemia in Seoul, Korea." European Journal of Nutrition, vol. 41, no. 3, 2002, pp. 101-7.
Jung K, Kim S, Woo J, et al. The efficacy of dietary intervention alone or combined with hormone replacement therapy in postmenopausal women with hypercholesterolemia in Seoul, Korea. Eur J Nutr. 2002;41(3):101-7.
Jung, K., Kim, S., Woo, J., & Chang, Y. (2002). The efficacy of dietary intervention alone or combined with hormone replacement therapy in postmenopausal women with hypercholesterolemia in Seoul, Korea. European Journal of Nutrition, 41(3), 101-7.
Jung K, et al. The Efficacy of Dietary Intervention Alone or Combined With Hormone Replacement Therapy in Postmenopausal Women With Hypercholesterolemia in Seoul, Korea. Eur J Nutr. 2002;41(3):101-7. PubMed PMID: 12111046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of dietary intervention alone or combined with hormone replacement therapy in postmenopausal women with hypercholesterolemia in Seoul, Korea. AU - Jung,Kyungah, AU - Kim,Sangyeon, AU - Woo,Jeongik, AU - Chang,Yookyung, PY - 2002/7/12/pubmed PY - 2002/11/26/medline PY - 2002/7/12/entrez SP - 101 EP - 7 JF - European journal of nutrition JO - Eur J Nutr VL - 41 IS - 3 N2 - BACKGROUND: Women have an increased incidence of cardiovascular disease (CVD) due to hormone imbalance-induced changes in blood lipid profiles after menopause. AIM OF STUDY: This study was done to compare the effects of dietary intervention and hormone replacement therapy, alone or in combination, on blood lipids and body weight in Korean postmenopausal women with hypercholesterolemia. METHOD: The subjects were treated by one of three different treatments for 12 weeks: hormone replacement therapy (HRT group, n = 8), dietary intervention (DIET group, n = 8) and hormone replacement therapy combined with dietary intervention (HRT+DIET group, n = 8). RESULTS: Serum TC and LDL-C levels decreased by 13-16 % and 24-28 % in the HRT group, by 17-19 % and 21-23 % in the DIET group and by 19-26 % and 32-39 % in the HRT+DIET group, respectively (P < 0.05). Serum HDL-C levels decreased in the DIET group (-6.4 %, P < 0.05) but not in the HRT and HRT+DIET groups. Serum TG levels increased in the HRT group (18 %, P < 0.05) but decreased in the DIET group (-24.4 %, P < 0.05). In the HRT+ DIET group, serum TG levels did not change. Body weight decreased only in the DIET group. CONCLUSIONS: We can conclude that dietary intervention produces a considerable improvement in blood lipid profiles and body weight, even though our study is limited by the sample size. Thus, the treatment to reduce risk of CVD should be individualized on the basis of the patient's dietary intake status, and at least, HRT should not be substituted for dietary intervention. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/12111046/The_efficacy_of_dietary_intervention_alone_or_combined_with_hormone_replacement_therapy_in_postmenopausal_women_with_hypercholesterolemia_in_Seoul_Korea_ L2 - https://dx.doi.org/10.1007/s003940200015 DB - PRIME DP - Unbound Medicine ER -