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Insulin-like growth factors and risk of benign prostatic hyperplasia.
Prostate. 2002 Jul 01; 52(2):98-105.P

Abstract

BACKGROUND

Insulin-like growth factors (IGFs) have potent growth mitogenic and anti-apoptotic effects on prostate tissue, whereas IGF binding proteins (IGFBPs) inhibit growth of prostatic tissue. The IGF axis has been implicated in prostate cancer risk, but its role in benign prostatic hyperplasia (BPH) is unclear.

METHODS

Plasma levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were determined from the fasting bloods of 206 BPH cases admitted for treatment and 306 randomly selected population controls in Shanghai, China.

RESULTS

Relative to the lowest tertile, men in the highest tertile of IGF-I levels had a significantly elevated risk of BPH (odds ratio [OR] = 2.80, 95% confidence interval [95% CI] = 1.60-4.92; P(trend) < 0.001). Results for IGF-I were more pronounced after adjustment for serum androgens. In contrast, men in the highest IGFBP-3 tertile had a significantly reduced risk (OR = 0.40; 95% CI = 0.23-0.69; P(trend) < 0.001). No associations of BPH with IGF-II and IGFBP-1 were observed.

CONCLUSION

As has been previously observed for prostate cancer, we found that IGF-I and IGFBP-3 are associated with BPH risk in China. Further investigation is needed to elucidate the role of the IGF axis in BPH etiology.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. chokkala@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12111701

Citation

Chokkalingam, Anand P., et al. "Insulin-like Growth Factors and Risk of Benign Prostatic Hyperplasia." The Prostate, vol. 52, no. 2, 2002, pp. 98-105.
Chokkalingam AP, Gao YT, Deng J, et al. Insulin-like growth factors and risk of benign prostatic hyperplasia. Prostate. 2002;52(2):98-105.
Chokkalingam, A. P., Gao, Y. T., Deng, J., Stanczyk, F. Z., Sesterhenn, I. A., Mostofi, F. K., Fraumeni, J. F., & Hsing, A. W. (2002). Insulin-like growth factors and risk of benign prostatic hyperplasia. The Prostate, 52(2), 98-105.
Chokkalingam AP, et al. Insulin-like Growth Factors and Risk of Benign Prostatic Hyperplasia. Prostate. 2002 Jul 1;52(2):98-105. PubMed PMID: 12111701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin-like growth factors and risk of benign prostatic hyperplasia. AU - Chokkalingam,Anand P, AU - Gao,Yu-Tang, AU - Deng,Jie, AU - Stanczyk,Frank Z, AU - Sesterhenn,Isabell A, AU - Mostofi,F K, AU - Fraumeni,Joseph F,Jr AU - Hsing,Ann W, PY - 2002/7/12/pubmed PY - 2002/9/24/medline PY - 2002/7/12/entrez SP - 98 EP - 105 JF - The Prostate JO - Prostate VL - 52 IS - 2 N2 - BACKGROUND: Insulin-like growth factors (IGFs) have potent growth mitogenic and anti-apoptotic effects on prostate tissue, whereas IGF binding proteins (IGFBPs) inhibit growth of prostatic tissue. The IGF axis has been implicated in prostate cancer risk, but its role in benign prostatic hyperplasia (BPH) is unclear. METHODS: Plasma levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were determined from the fasting bloods of 206 BPH cases admitted for treatment and 306 randomly selected population controls in Shanghai, China. RESULTS: Relative to the lowest tertile, men in the highest tertile of IGF-I levels had a significantly elevated risk of BPH (odds ratio [OR] = 2.80, 95% confidence interval [95% CI] = 1.60-4.92; P(trend) < 0.001). Results for IGF-I were more pronounced after adjustment for serum androgens. In contrast, men in the highest IGFBP-3 tertile had a significantly reduced risk (OR = 0.40; 95% CI = 0.23-0.69; P(trend) < 0.001). No associations of BPH with IGF-II and IGFBP-1 were observed. CONCLUSION: As has been previously observed for prostate cancer, we found that IGF-I and IGFBP-3 are associated with BPH risk in China. Further investigation is needed to elucidate the role of the IGF axis in BPH etiology. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/12111701/Insulin_like_growth_factors_and_risk_of_benign_prostatic_hyperplasia_ L2 - https://doi.org/10.1002/pros.10096 DB - PRIME DP - Unbound Medicine ER -