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Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian women.
Am J Hematol. 2002 Jul; 70(3):186-90.AJ

Abstract

We have examined the independent effect of vitamin B(12) deficiency on hematological indices in older Chinese vegetarian women using a cross-sectional study design: 119 women older than 55 years who had been vegetarian for more than 3 years were studied. Fasting blood samples were taken for complete blood count, serum iron, total serum iron binding capacity, serum iron saturation, serum vitamin B(12), serum folate, serum methylmalonic acid levels (MMA), and renal function test. Subjects with iron deficiency (iron saturation <15%) and those with serum creatinine >150 mmol/L were excluded. The prevalence of definite vitamin B(12) deficiency (vitamin B(12) level < 150 pmol/L and MMA >or= 0.4 micromol/L) was 42%. Another 32.8% had possible vitamin B(12) deficiency (either criterion). The prevalence of iron deficiency was 10%. After exclusions, 96 subjects were further analyzed. Vitamin B(12) deficiency defined by serum vitamin B(12) and MMA was associated with a decrease in hemoglobin concentrations by up to 0.9 g/dL, but it was not associated with an increase in mean corpuscular volume (MCV). Serum MMA but not vitamin B(12) levels correlated inversely with hemoglobin and platelet counts and positively with MCV, after adjustment of confounding factors. However, the percentage of subjects with anemia did not increase significantly until serum MMA became >1.0 micromol/L. In conclusion, vitamin B(12) deficiency was associated with a significant decrease in hemoglobin concentration. However, anemia associated with vitamin B(12) deficiency was seldom macrocytic. We recommend that older vegetarians should be given vitamin B(12) supplements routinely.

Authors+Show Affiliations

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin. tkwok@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12111763

Citation

Kwok, T, et al. "Independent Effect of Vitamin B12 Deficiency On Hematological Status in Older Chinese Vegetarian Women." American Journal of Hematology, vol. 70, no. 3, 2002, pp. 186-90.
Kwok T, Cheng G, Woo J, et al. Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian women. Am J Hematol. 2002;70(3):186-90.
Kwok, T., Cheng, G., Woo, J., Lai, W. K., & Pang, C. P. (2002). Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian women. American Journal of Hematology, 70(3), 186-90.
Kwok T, et al. Independent Effect of Vitamin B12 Deficiency On Hematological Status in Older Chinese Vegetarian Women. Am J Hematol. 2002;70(3):186-90. PubMed PMID: 12111763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian women. AU - Kwok,T, AU - Cheng,G, AU - Woo,J, AU - Lai,W K, AU - Pang,C P, PY - 2002/7/12/pubmed PY - 2002/7/27/medline PY - 2002/7/12/entrez SP - 186 EP - 90 JF - American journal of hematology JO - Am. J. Hematol. VL - 70 IS - 3 N2 - We have examined the independent effect of vitamin B(12) deficiency on hematological indices in older Chinese vegetarian women using a cross-sectional study design: 119 women older than 55 years who had been vegetarian for more than 3 years were studied. Fasting blood samples were taken for complete blood count, serum iron, total serum iron binding capacity, serum iron saturation, serum vitamin B(12), serum folate, serum methylmalonic acid levels (MMA), and renal function test. Subjects with iron deficiency (iron saturation <15%) and those with serum creatinine >150 mmol/L were excluded. The prevalence of definite vitamin B(12) deficiency (vitamin B(12) level < 150 pmol/L and MMA >or= 0.4 micromol/L) was 42%. Another 32.8% had possible vitamin B(12) deficiency (either criterion). The prevalence of iron deficiency was 10%. After exclusions, 96 subjects were further analyzed. Vitamin B(12) deficiency defined by serum vitamin B(12) and MMA was associated with a decrease in hemoglobin concentrations by up to 0.9 g/dL, but it was not associated with an increase in mean corpuscular volume (MCV). Serum MMA but not vitamin B(12) levels correlated inversely with hemoglobin and platelet counts and positively with MCV, after adjustment of confounding factors. However, the percentage of subjects with anemia did not increase significantly until serum MMA became >1.0 micromol/L. In conclusion, vitamin B(12) deficiency was associated with a significant decrease in hemoglobin concentration. However, anemia associated with vitamin B(12) deficiency was seldom macrocytic. We recommend that older vegetarians should be given vitamin B(12) supplements routinely. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/12111763/Independent_effect_of_vitamin_B12_deficiency_on_hematological_status_in_older_Chinese_vegetarian_women_ L2 - https://doi.org/10.1002/ajh.10134 DB - PRIME DP - Unbound Medicine ER -