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Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: a pilot study.
Mov Disord. 2002 May; 17(3):474-81.MD

Abstract

Six patients with Parkinson's disease (PD) reporting unusually fast or sudden onset of sleep under the addition of dopamine agonists to a previous levodopa-containing therapy were examined using a sleep-wake diary, the Epworth sleepiness scale (ESS), polysomnography, multiple sleep latency tests (MSLT), a standardized vigilance test, and driving simulation. In all patients, ESS scores were increased and polysomnography showed disruption of the sleep pattern, a tendency towards poor sleep efficiency, and reduced proportions of slow- wave and rapid eye movement sleep. Pathological results in the MSLT or the vigilance test were obtained in five cases. For evaluation of driving performance, the standard deviation from the mean lane position during driving simulation was calculated. Three of five patients had clearly increased mean SDLP values. With respect to the measurement of daytime sleepiness (ESS, MSLT, vigilance test, and driving simulation), each patient had pathological results in at least two of these examinations. However, only a limited transfer of the routine vigilance assessment to driving performance was possible. In summary, this pilot study indicates that unusually fast or sudden onset of sleep in PD patients is a phenomenon of daytime sleepiness.

Authors+Show Affiliations

Department of Neurology, Philipps University, Marburg, Germany. moellerc@mailer.uni-marburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12112193

Citation

Möller, J Carsten, et al. "Evaluation of Sleep and Driving Performance in Six Patients With Parkinson's Disease Reporting Sudden Onset of Sleep Under Dopaminergic Medication: a Pilot Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 17, no. 3, 2002, pp. 474-81.
Möller JC, Stiasny K, Hargutt V, et al. Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: a pilot study. Mov Disord. 2002;17(3):474-81.
Möller, J. C., Stiasny, K., Hargutt, V., Cassel, W., Tietze, H., Peter, J. H., Krüger, H. P., & Oertel, W. H. (2002). Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: a pilot study. Movement Disorders : Official Journal of the Movement Disorder Society, 17(3), 474-81.
Möller JC, et al. Evaluation of Sleep and Driving Performance in Six Patients With Parkinson's Disease Reporting Sudden Onset of Sleep Under Dopaminergic Medication: a Pilot Study. Mov Disord. 2002;17(3):474-81. PubMed PMID: 12112193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: a pilot study. AU - Möller,J Carsten, AU - Stiasny,Karin, AU - Hargutt,Volker, AU - Cassel,Werner, AU - Tietze,Heiko, AU - Peter,J Hermann, AU - Krüger,H-Peter, AU - Oertel,Wolfgang H, PY - 2002/7/12/pubmed PY - 2002/9/17/medline PY - 2002/7/12/entrez SP - 474 EP - 81 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 17 IS - 3 N2 - Six patients with Parkinson's disease (PD) reporting unusually fast or sudden onset of sleep under the addition of dopamine agonists to a previous levodopa-containing therapy were examined using a sleep-wake diary, the Epworth sleepiness scale (ESS), polysomnography, multiple sleep latency tests (MSLT), a standardized vigilance test, and driving simulation. In all patients, ESS scores were increased and polysomnography showed disruption of the sleep pattern, a tendency towards poor sleep efficiency, and reduced proportions of slow- wave and rapid eye movement sleep. Pathological results in the MSLT or the vigilance test were obtained in five cases. For evaluation of driving performance, the standard deviation from the mean lane position during driving simulation was calculated. Three of five patients had clearly increased mean SDLP values. With respect to the measurement of daytime sleepiness (ESS, MSLT, vigilance test, and driving simulation), each patient had pathological results in at least two of these examinations. However, only a limited transfer of the routine vigilance assessment to driving performance was possible. In summary, this pilot study indicates that unusually fast or sudden onset of sleep in PD patients is a phenomenon of daytime sleepiness. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/12112193/Evaluation_of_sleep_and_driving_performance_in_six_patients_with_Parkinson's_disease_reporting_sudden_onset_of_sleep_under_dopaminergic_medication:_a_pilot_study_ L2 - https://doi.org/10.1002/mds.10020 DB - PRIME DP - Unbound Medicine ER -