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Disordered respiration as a levodopa-induced dyskinesia in Parkinson's disease.
Mov Disord. 2002 May; 17(3):524-7.MD

Abstract

Symptomatic respiratory disturbance as a consequence of levodopa (L-dopa) therapy for Parkinson's disease (PD) has been described only rarely and may be underrecognized in clinical practice. We report on two patients with PD in whom the introduction or augmentation of L-dopa therapy was associated with the development of irregular and rapid breathing. Analysis of breathing patterns before and after L-dopa demonstrated a striking change in respiratory rate after administration of L-dopa, with the emergence of irregular tachypnea alternating with brief periods of apnea, in a pattern consistent with a central origin. In both cases, the temporal relationship of the respiratory disturbance to the administration of L-dopa suggested a peak-dose drug effect. Previous reports of L-dopa-induced respiratory dyskinesia are reviewed, and the potential mechanisms whereby L-dopa might influence the central control of respiration to produce irregular breathing patterns are discussed.

Authors+Show Affiliations

Department of Neurology, Royal Adelaide Hospital, Adelaide, S Australia, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12112201

Citation

Rice, J E., et al. "Disordered Respiration as a Levodopa-induced Dyskinesia in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 17, no. 3, 2002, pp. 524-7.
Rice JE, Antic R, Thompson PD. Disordered respiration as a levodopa-induced dyskinesia in Parkinson's disease. Mov Disord. 2002;17(3):524-7.
Rice, J. E., Antic, R., & Thompson, P. D. (2002). Disordered respiration as a levodopa-induced dyskinesia in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 17(3), 524-7.
Rice JE, Antic R, Thompson PD. Disordered Respiration as a Levodopa-induced Dyskinesia in Parkinson's Disease. Mov Disord. 2002;17(3):524-7. PubMed PMID: 12112201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disordered respiration as a levodopa-induced dyskinesia in Parkinson's disease. AU - Rice,J E, AU - Antic,R, AU - Thompson,Philip D, PY - 2002/7/12/pubmed PY - 2002/9/17/medline PY - 2002/7/12/entrez SP - 524 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 17 IS - 3 N2 - Symptomatic respiratory disturbance as a consequence of levodopa (L-dopa) therapy for Parkinson's disease (PD) has been described only rarely and may be underrecognized in clinical practice. We report on two patients with PD in whom the introduction or augmentation of L-dopa therapy was associated with the development of irregular and rapid breathing. Analysis of breathing patterns before and after L-dopa demonstrated a striking change in respiratory rate after administration of L-dopa, with the emergence of irregular tachypnea alternating with brief periods of apnea, in a pattern consistent with a central origin. In both cases, the temporal relationship of the respiratory disturbance to the administration of L-dopa suggested a peak-dose drug effect. Previous reports of L-dopa-induced respiratory dyskinesia are reviewed, and the potential mechanisms whereby L-dopa might influence the central control of respiration to produce irregular breathing patterns are discussed. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/12112201/Disordered_respiration_as_a_levodopa_induced_dyskinesia_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.10072 DB - PRIME DP - Unbound Medicine ER -